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http://dx.doi.org/10.4110/in.2011.11.4.191

Stimulatory Effect of ${\beta}$-glucans on Immune Cells  

Kim, Hyung-Sook (College of Pharmacy, Chungbuk National University)
Hong, Jin-Tae (College of Pharmacy, Chungbuk National University)
Kim, Young-Soo (College of Pharmacy, Chungbuk National University)
Han, Sang-Bae (College of Pharmacy, Chungbuk National University)
Publication Information
IMMUNE NETWORK / v.11, no.4, 2011 , pp. 191-195 More about this Journal
Abstract
${\beta}$-Glucans are naturally occurring polysaccharides that are produced by bacteria, yeast, fungi, and many plants. Although their pharmacological activities, such as immunomodulatory, anti-infective and anti-cancer effects, have been well studied, it is still unclear how ${\beta}$-glucans exert their activities. However, recent studies on the ${\beta}$-glucans receptors shed some light on their mechanism of action. Since ${\beta}$-glucans have large molecular weights, they must bind surface receptors to activate immune cells. In this review, we summarize the immunopharmacological activities and the potential receptors of ${\beta}$-glucans in immune cells.
Keywords
${\beta}$-glucan; Receptors; Immune cells;
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1 Chen J, Seviour R: Medicinal importance of fungal beta-( 1-->3), (1-->6)-glucans. Mycol Res 111;635-52, 2007.   DOI   ScienceOn
2 Suzuki M, Takatsuki F, Maeda YY, Hamuro J, Chihara G: Antitumor and immunological activity of lentinan in comparison with LPS. Int J Immunopharmacol 16;463-8, 1994.
3 Zhang L, Li X, Xu X, Zeng F: Correlation between antitumor activity, molecular weight, and conformation of lentinan. Carbohydr Res 340;1515-21, 2005.   DOI   ScienceOn
4 Jamois F, Ferrieres V, Guegan JP, Yvin JC, Plusquellec D, Vetvicka V: Glucan-like synthetic oligosaccharides: iterative synthesis of linear oligo-beta-(1,3)-glucans and immunostimulatory effects. Glycobiology 15;393-407, 2005.   DOI
5 Mueller A, Raptis J, Rice PJ, Kalbfleisch JH, Stout RD, Ensley HE, Browder W, Williams DL: The influence of glucan polymer structure and solution conformation on binding to (1-->3)-beta-D-glucan receptors in a human monocyte-like cell line. Glycobiology 10;339-46, 2000.   DOI   ScienceOn
6 Wang Y, Zhang L, Li Y, Hou X, Zeng F: Correlation of structure to antitumor activities of five derivatives of a beta-glucan from Poria cocos sclerotium. Carbohydr Res 339;2567-74, 2004.   DOI   ScienceOn
7 Chihara G, Hamuro J, Maeda Y, Arai Y, Fukuoka F: Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom). Cancer Res 30;2776-81, 1970.
8 Zhou LD, Zhang QH, Zhang Y, Liu J, Cao YM: The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria blood-stage infection by evoking adaptive immune- responses. Int Immunopharmacol 9;455-62, 2009.   DOI   ScienceOn
9 Harada K, Itashiki Y, Takenawa T, Ueyama Y: Effects of lentinan alone and in combination with fluoropyrimidine anticancer agent on growth of human oral squamous cell carcinoma in vitro and in vivo. Int J Oncol 37;623-31, 2010.
10 Sier CF, Gelderman KA, Prins FA, Gorter A: Beta-glucan enhanced killing of renal cell carcinoma micrometastases by monoclonal antibody G250 directed complement activation. Int J Cancer 109;900-8, 2004.   DOI   ScienceOn
11 Palma AS, Feizi T, Zhang Y, Stoll MS, Lawson AM, Diaz-Rodriguez E, Campanero-Rhodes MA, Costa J, Gordon S, Brown GD, Chai W: Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides. J Biol Chem 281;5771-9, 2006.   DOI
12 Brown GD, Taylor PR, Reid DM, Willment JA, Williams DL, Martinez-Pomares L, Wong SY, Gordon S: Dectin-1 is a major beta-glucan receptor on macrophages. J Exp Med 196;407-12, 2002.   DOI   ScienceOn
13 Grunebach F, Weck MM, Reichert J, Brossart P: Molecular and functional characterization of human Dectin-1. Exp Hematol 30;1309-15, 2002.   DOI   ScienceOn
14 Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, Gordon S, Tybulewicz VL, Brown GD, Reis e Sousa C: Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22;507-17, 2005.   DOI   ScienceOn
15 Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Ram MK, Theriault K, Zoller MJ, Karas JL: Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 377;32-8, 1995.   DOI   ScienceOn
16 Xu S, Huo J, Lee KG, Kurosaki T, Lam KP: Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells. J Biol Chem 284;7038-46, 2009.   DOI
17 Shah VB, Ozment-Skelton TR, Williams DL, Keshvara L: Vav1 and PI3K are required for phagocytosis of beta-glucan and subsequent superoxide generation by microglia. Mol Immunol 46;1845-53, 2009.   DOI   ScienceOn
18 Takeda K, Akira S: TLR signaling pathways. Semin Immunol 16;3-9, 2004.   DOI   ScienceOn
19 Lebron F, Vassallo R, Puri V, Limper AH: Pneumocystis carinii cell wall beta-glucans initiate macrophage inflammatory responses through NF-kappaB activation. J Biol Chem 278; 25001-8, 2003.   DOI
20 Kim HS, Kim JY, Ryu HS, Shin BR, Kang JS, Kim HM, Kim YO, Hong JT, Kim Y, Han SB: Phenotypic and functional maturation of dendritic cells induced by polysaccharide isolated from Paecilomyces cicadae. J Med Food 14;847-56, 2011.   DOI   ScienceOn
21 Kim HS, Kim JY, Kang JS, Kim HM, Kim YO, Hong IP, Lee MK, Hong JT, Kim Y, Han SB: Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings. Food Chem Toxicol 48;1926-33, 2010.   DOI   ScienceOn
22 Han SB, Lee CW, Kang MR, Yoon YD, Kang JS, Lee KH, Yoon WK, Lee K, Park SK, Kim HM: Pectic polysaccharide isolated from Angelica gigas Nakai inhibits melanoma cell metastasis and growth by directly preventing cell adhesion and activating host immune functions. Cancer Lett 243;264-73, 2006.   DOI   ScienceOn
23 Han SB, Yoon YD, Ahn HJ, Lee HS, Lee CW, Yoon WK, Park SK, Kim HM: Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus. Int Immunopharmacol 3;1301-12, 2003.   DOI   ScienceOn
24 Han SB, Park SK, Ahn HJ, Yoon YD, Kim YH, Lee JJ, Lee KH, Moon JS, Kim HC, Kim HM: Characterization of B cell membrane receptors of polysaccharide isolated from the root of Acanthopanax koreanum. Int Immunopharmacol 3;683-91, 2003.   DOI   ScienceOn
25 Han SB, Park SH, Lee KH, Lee CW, Lee SH, Kim HC, Kim YS, Lee HS, Kim HM: Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells. Int Immunopharmacol 1;1969-78, 2001.   DOI   ScienceOn
26 Brown GD: Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol 6;33-43, 2006.   DOI   ScienceOn
27 Dennehy KM, Ferwerda G, Faro-Trindade I, Pyz E, Willment JA, Taylor PR, Kerrigan A, Tsoni SV, Gordon S, Meyer- Wentrup F, Adema GJ, Kullberg BJ, Schweighoffer E, Tybulewicz V, Mora-Montes HM, Gow NA, Williams DL, Netea MG, Brown GD: Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur J Immunol 38;500-6, 2008.   DOI   ScienceOn
28 Thornton BP, Vetvicka V, Pitman M, Goldman RC, Ross GD: Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). J Immunol 156;1235-46, 1996.
29 Xia Y, Vetvicka V, Yan J, Hanikyrova M, Mayadas T, Ross GD: The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells. J Immunol 162;2281-90, 1999.
30 Li B, Allendorf DJ, Hansen R, Marroquin J, Ding C, Cramer DE, Yan J: Yeast beta-glucan amplifies phagocyte killing of iC3b-opsonized tumor cells via complement receptor 3-Syk-phosphatidylinositol 3-kinase pathway. J Immunol 177; 1661-9, 2006.   DOI
31 Jimenez-Lucho V, Ginsburg V, Krivan HC: Cryptococcus neoformans, Candida albicans, and other fungi bind specifically to the glycosphingolipid lactosylceramide (Gal beta 1-4Glc beta 1-1Cer), a possible adhesion receptor for yeasts. Infect Immun 58;2085-90, 1990.
32 Zimmerman JW, Lindermuth J, Fish PA, Palace GP, Stevenson TT, DeMong DE: A novel carbohydrate-glycosphingolipid interaction between a beta-(1-3)-glucan immunomodulator, PGG-glucan, and lactosylceramide of human leukocytes. J Biol Chem 273;22014-20, 1998.   DOI
33 Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW: Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells. Infect Immun 73;2766-77, 2005.   DOI   ScienceOn
34 Acton SL, Scherer PE, Lodish HF, Krieger M: Expression cloning of SR-BI, a CD36-related class B scavenger receptor. J Biol Chem 269;21003-9, 1994.
35 Assanasen C, Mineo C, Seetharam D, Yuhanna IS, Marcel YL, Connelly MA, Williams DL, de la Llera-Moya M, Shaul PW, Silver DL: Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling. J Clin Invest 115;969-77, 2005.   DOI
36 Wang J, Dong S, Liu C, Wang W, Sun S, Gu J, Wang Y, Boraschi D, Qu D: beta-Glucan oligosaccharide enhances CD8(+) T cells immune response induced by a DNA vaccine encoding hepatitis B virus core antigen. J Biomed Biotechnol 2010;645213, 2010.
37 Demleitner S, Kraus J, Franz G: Synthesis and antitumour activity of sulfoalkyl derivatives of curdlan and lichenan. Carbohydr Res 226;247-52, 1992.   DOI   ScienceOn
38 McIntosh M, Stone BA, Stanisich VA: Curdlan and other bacterial (1-->3)-beta-D-glucans. Appl Microbiol Biotechnol 68;163-73, 2005.   DOI   ScienceOn
39 Kerekgyarto C, Virag L, Tanko L, Chihara G, Fachet J: Strain differences in the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan. Int J Immunopharmacol 18;347-53, 1996.   DOI   ScienceOn
40 Chan WK, Law HK, Lin ZB, Lau YL, Chan GC: Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley. Int Immunol 19;891-9, 2007.   DOI   ScienceOn
41 McCormack E, Skavland J, Mujic M, Bruserud O, Gjertsen BT: Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia. Nutr Cancer 62;574-83, 2010.   DOI   ScienceOn
42 Yoshino S, Tabata T, Hazama S, Iizuka N, Yamamoto K, Hirayama M, Tangoku A, Oka M: Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers. Anticancer Res 20;4707-11, 2000.
43 Murata Y, Shimamura T, Tagami T, Takatsuki F, Hamuro J: The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content. Int Immunopharmacol 2;673-89, 2002.   DOI   ScienceOn
44 Vetvicka V, Vetvickova J, Frank J, Yvin JC: Enhancing effects of new biological response modifier beta-1,3 glucan sulfate PS3 on immune reactions. Biomed Pharmacother 62;283-8, 2008.   DOI   ScienceOn
45 Brown GD, Gordon S: Immune recognition of fungal beta- glucans. Cell Microbiol 7;471-9, 2005.   DOI   ScienceOn
46 Ariizumi K, Shen GL, Shikano S, Xu S, Ritter R 3rd, Kumamoto T, Edelbaum D, Morita A, Bergstresser PR, Takashima A: Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem 275; 20157-67, 2000.   DOI
47 Adachi Y, Ishii T, Ikeda Y, Hoshino A, Tamura H, Aketagawa J, Tanaka S, Ohno N: Characterization of beta-glucan recognition site on C-type lectin, dectin 1. Infect Immun 72;4159-71, 2004.   DOI