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http://dx.doi.org/10.4110/in.2009.9.6.285

Expression Pattern of Immunoproteasome Subunits in Human Thymus  

Oh, Kwon-Ik (Department of Pathology, Hallym University College of Medicine)
Seo, Jae-Nam (Department of Pathology, Hallym University College of Medicine)
Publication Information
IMMUNE NETWORK / v.9, no.6, 2009 , pp. 285-288 More about this Journal
Abstract
The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes.
Keywords
immunoproteasome; MHC (major histocompatibility complex); peptide; selection;
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1 Toes RE, Nussbaum AK, Degermann S, Schirle M, Emmerich NP, Kraft M, Laplace C, Zwinderman A, Dick TP, Muller J, Schonfisch B, Schmid C, Fehling HJ, Stevanovic S, Rammensee HG, Schild H: Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products. J Exp Med 194;1-12, 2001   DOI
2 Bandoh N, Ogino T, Cho HS, Hur SY, Shen J, Wang X, Kato S, Miyokawa N, Harabuchi Y, Ferrone S: Development and characterization of human constitutive proteasome and immunoproteasome subunit-specific monoclonal antibodies. Tissue Antigens 66;185-194, 2005   DOI   ScienceOn
3 Niedermann G: Immunological functions of the proteasome. Curr Top Microbiol Immunol 268;91-136, 2002
4 Jameson SC, Hogquist KA, Bevan MJ: Positive selection of thymocytes. Annu Rev Immunol 13;93-126, 1995   DOI   ScienceOn
5 Barton GM, Rudensky AY: Requirement for diverse, low-abundance peptides in positive selection of T cells. Science 283;67-70, 1999   DOI
6 Nil A, Firat E, Sobek V, Eichmann K, Niedermann G: Expression of housekeeping and immunoproteasome subunit genes is differentially regulated in positively and negatively selecting thymic stroma subsets. Eur J Immunol 34;2681-2689, 2004   DOI   ScienceOn
7 Chen W, Norbury CC, Cho Y, Yewdell JW, Bennink JR: Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens. J Exp Med 193;1319-1326, 2001   DOI   ScienceOn
8 Fruh K, Gossen M, Wang K, Bujard H, Peterson PA, Yang Y: Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex. Embo J 13;3236-3244, 1994
9 Gaczynska M, Rock KL, Spies T, Goldberg AL: Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7. Proc Natl Acad Sci U S A 91;9213-9217, 1994   DOI   ScienceOn
10 Tanaka K, Kasahara M: The MHC class I ligand-generating system: roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28. Immunol Rev 163;161-176, 1998   DOI   ScienceOn
11 Starr TK, Jameson SC, Hogquist KA: Positive and negative selection of T cells. Annu Rev Immunol 21;139-176, 2003   DOI   ScienceOn
12 Siggs OM, Makaroff LE, Liston A: The why and how of thymocyte negative selection. Curr Opin Immunol 18;175-183, 2006   DOI   ScienceOn
13 Cosgrove D, Chan SH, Waltzinger C, Benoist C, Mathis D: The thymic compartment responsible for positive selection of CD4+ T cells. Int Immunol 4;707-710, 1992   DOI   ScienceOn
14 Anderson G, Jenkinson EJ: Lymphostromal interactions in thymic development and function. Nat Rev Immunol 1; 31-40, 2001   DOI   ScienceOn
15 Kloetzel PM, Ossendorp F: Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr Opin Immunol 16;76-81, 2004   DOI   ScienceOn