The Binding Properties of Glycosylated and Non- Glycosylated Tim-3 Molecules on |
Lee, Mi-Jin
(Department of Microbiology and Immunology, Ajou University School of Medicine)
Heo, Yoo-Mi (Department of Microbiology and Immunology, Ajou University School of Medicine) Hong, Seung-Ho (Department of Microbiology and Immunology, Ajou University School of Medicine) Kim, Kyong-Min (Department of Microbiology and Immunology, Ajou University School of Medicine) Park, Sun (Department of Microbiology and Immunology, Ajou University School of Medicine) |
1 | Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK: Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415;536-541, 2002 DOI ScienceOn |
2 | Sabatos CA, Chakravarti S, Cha E, Schubart A, Sanchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK: Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol 4;1102-1110, 2003 DOI ScienceOn |
3 | Oikawa T, Kamimura Y, Akiba H, Yagita H, Okumura K, Takahashi H, Zeniya M, Tajiri H, Azuma M: Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease. J Immunol 177;4281-4287, 2006 DOI PUBMED |
4 | Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK: The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6;1245-1252, 2005 DOI ScienceOn |
5 | Medzihradszky KF: Characterization of site-specific N-glycosylation. Methods Mol Biol 446:293-316, 2008 DOI PUBMED ScienceOn |
6 | Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, Watanabe K, Ito K, Takeshita K, Niki T, Saita N, Nishi N, Yamauchi A, Katoh S, Matsukawa A, Kuchroo V, Hirashima M: Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol 127:78-88, 2008 DOI ScienceOn |
7 | Kuchroo VK, Meyers JH, Umetsu DT, DeKruyff RH: TIM family of genes in immunity and tolerance. Adv Immunol 91;227-249, 2006 DOI PUBMED ScienceOn |
8 | Sanchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutierrez-Ramos JC, Coyle AJ, Strom TB: Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol 4;1093-1101, 2003 DOI ScienceOn |
9 | Wiener Z, Kohalmi B, Pocza P, Jeager J, Tolgyesi G, Toth S, Gorbe E, Papp Z, Falus A: TIM-3 is expressed in melanoma cells and is upregulated in TGF-beta stimulated mast cells. J Invest Dermatol 127;906-914, 2007 DOI ScienceOn |
10 | Frisancho-Kiss S, Nyland JF, Davis SE, Barrett MA, Gatewood SJ, Njoku DB, Cihakova D, Silbergeld EK, Rose NR, Fairweather D: Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J Immunol 176;6411-6415, 2006 DOI PUBMED |
11 | Cao E, Zang X, Ramagopal UA, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, Dilorenzo TP, Allison JP, Nathenson SG, Almo SC: T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity 26;311-321, 2007 DOI ScienceOn |
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