Browse > Article

Decreased Serum Immunoglobulin in Recurrent Otitis Media with Effusion  

Shin, Il-Ho (Department of Otorhinolaryngology, Head & Nack Surgery, College of Medicine, Kyung Hee University)
Park, Dong-Choon (Department of Obstetric and Gynecology, College of Medicine, The Catholic University of Korea)
Byun, Jae-Yong (Department of Otorhinolaryngology, Head & Nack Surgery, College of Medicine, Kyung Hee University)
Park, Moon-Seo (Department of Otorhinolaryngology, Head & Nack Surgery, College of Medicine, Kyung Hee University)
Cha, Chang-Il (Department of Otorhinolaryngology, Head & Nack Surgery, College of Medicine, Kyung Hee University)
Yeo, Seung-Geun (Department of Otorhinolaryngology, Head & Nack Surgery, College of Medicine, Kyung Hee University)
Publication Information
IMMUNE NETWORK / v.7, no.2, 2007 , pp. 75-79 More about this Journal
Abstract
Background: Defective or immature antibody responses to pathogens in children may explain the increased susceptibility to acute otitis media. However, there is no study in Korea patients whether a correlation exists between otitis media with effusion and the levels of serum immunoglobulins, IgG subclasses, IgA, IgM and IgE. Methods: 45 children with otitis media with effusion more than 4 episodes in 12 months or 3 episodes in 6 months, 62 children with otitis media with effusion less than 3 episodes in 12 months and 102 children for control group took part in the study at the Department of Otorhinolaryngology of the KyungHee University from May 2004 to Feburary 2007. Serum immunoglobulin levels were determined by nephelometry. And then the relationship between otitis media with effusion and serum immunoglobulin level was evaluated. Results: In otitis media prone group, serum IgG1, IgG2, IgG4, and IgA level was lower than those level of control group, it was significantly decreased (p<0.05). In otitis media group, serum IgA, IgE, and IgG4 level was lower than those level of control. But it was not statistically significant (p>0.05). Conclusion: Lower immunoglobulins in children with otitis media with effusion suggest a generalized decreased antibody responses. Lower levels of serum IgG1, IgG2, IgG4, and IgA may be related with chronicity or intractability of otitis media with effusion.
Keywords
Otitis media with effusion; serum immunoglobulin;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Cummings CW: Otolaryngology Head & Neck surgery. 4th ed. p. 4445-4450
2 Prellner K, Kalm O: Humoral immune response in acute otitis media. Acta Otolarygol Suppl 457;133-138, 1989
3 Howie VM, Plouss JH, Sloyer J: The 'otitis-prone' condition. Am J Dis Child 129;67-68, 1975
4 김세종: 면역글로블린의 구조와 기능. 면역학. 서울. 고려의학. p. 48-59
5 Goodman JW: Immunoglobulin struture. In: Stited DP, Terr Al eds: Basic and Clinical Immunology, p109-121, Connecticut Prentice-Hall, 1991
6 Hirata CH, Weckx LL, Sole D, Figueiredo CR: Serum levels of immunoglobulins in children with recurrent otitis media. J Invest Allergol Clin Immunol 9;106-109, 1999
7 Diamant M, Diamant B: Abuse and timing of use of antibiotics in acute otitis media. Arch Otolaryngol 100;226-232, 1974   DOI   PUBMED
8 Smith, CI, Hammarstrom L, Henter JL, De Lange GG: Molecular and serologic analysis of deficiency caused by new forms of the constant region of the IgH chain gene deletions. J Immunol 142;4514-4519, 1989   PUBMED
9 Gross S, Blaiss MS, Herrod HG: Role of immunoglobulinsubclasses and specific antibody determinations in the evaluation of recurrent infection in children. J Pediatr 120;256-266, 1964
10 Bluestone CD, Klein JO: Clinical practice guideline on otitis media with effusion in young children: strengths and weaknesses. Otolaryngol Head & Neck Surg 112;507-511, 1995   DOI   ScienceOn
11 Umetsu DT, Ambrosino DM, Geha RS: Children with selective IgG subclass deficiency and recurrent sinopulmonary infection: impaired response to bacterial capsular polysaccharide antigen. N Engl J Med 304;1476-1477, 1981   DOI   PUBMED   ScienceOn
12 Oxelius VA: IgG subclass levels in infancy and childhood. Acta Paediat Scand 68;23-27, 1979   DOI
13 Soderstrom T, Soderstrom R, Bengtssom U, Bjorkander J, Hellstrand K, Holm J, Hanson LA: Clinical and immunological evaluation of patients low in single or multiple IgG subclass. Monogr Allergy 20;135-142, 1986   PUBMED
14 Carneiro-Sampaio MMS, Carbonare SB, Rozentraub RB, Araujo MNT, Ribeiro MA, Porto MHO: Frequency of selective IgA deficiency among Brazilian blood donors and healthy pregnant womwn. Allergol Immunopathol 17;213-216, 1989   PUBMED
15 Kim LS, Han CS: Pathophysiology of otitis media with effusion. J Clinical Otolaryngol 11;197-205, 2000
16 Veenhoven R, Rijkers G, Schilder A, Adelmeijer J, Uiterwaal C, Kuis W: Immunoglobulins in otitis-prone children. Pediatric Research 55;159-163, 2004   DOI   ScienceOn
17 Bernstein JM: Role of allergy in eustachian tube blockage and otitis media with effusion: a review. Otolaryngol Head Neck Surg 114;562-568, 1996   DOI   ScienceOn
18 Goldbaltt D, Morgan G, Seymour ND: The clinical manifestations of IgG subclass deficiency. London Royal Society of Medicine Services Limited 19-26, 1989
19 Aino R, Olli M, Simo N, Tuukka S, Aimo S, Matti W, Riikka O, Erkki E, Tobias A, Hubert N, Terho H, Olli R: Microbiology of acute otitis media in children with tympanostomy tubes: prevlences of bacteria and viruses. Clinical Infectious Diseases 43;1417-1422, 2006   DOI   ScienceOn