Browse > Article

The Development of Signal Processing Software for Single-and Multi-Voxel MR Spectroscopy  

Paik, Moon-Young (Graduate School of Medical Imaging Science Inje Univ. of Korea)
Lee, Hyun-Yong (Dept. of Diagnositc Radiology, Paik Hospital of Korea)
Shin, Oun-Jae (Dept. of Diagnositc Radiology, Paik Hospital of Korea)
Eun, Choong-Ki (Dept. of Diagnostic Radiology, College of Medicine, Inje Uni. of Krea)
Mu, Chi-Woong (Dept. of Biomedical Engineering, Inje Univ. of Korea)
Publication Information
Journal of the Institute of Electronics Engineers of Korea SP / v.39, no.5, 2002 , pp. 544-555 More about this Journal
Abstract
The aim of this study is to develop the $^1H$-MRS data postprocessing software for both single-voxel and multi-voxel technique, which plays and important role as a diagnostic tool in clinical field. This software is based on graphical user interface(GUI) under windows operating system of personal computer(PC). In case of single-voxel MRS, both of raw data in time-domain and spectrum data in frequency-domain are simultaneously displayed in a screen. Several functions such as DC correction, zero filling, line broadening, Lorentz-Gauss filtering and phase correction, etc. are included to increase the quality of spectrum data. In case of multi-voxel analysis, spectroscopic image reconstructed by 3-D FFT was displayed as a spectral grid and overlapped over previously obtained T1- or T2-weighted image for the spectra to be spatially registered with the image. The analysis of MRS peaks were performed by obtaining the ratio of peak area. In single-voxel method, statistically processed peak-area ratios of MRS data obtained from normal human brain are presented. Using multi-voxel method, MR spectroscopic image and metabolite image acquired from brain tumor are demonstrated.
Keywords
Citations & Related Records
연도 인용수 순위
  • Reference
1 U Sonnewald, IS Gribbestad, N Westergard et al, 'Nuclear magnetic resonance spectroscopy: biochemical evaluation of brain function in vivo and in vitro', Neurotoxicology, Vol. 15, pp. 579-590, 1994
2 O Henriksen, 'MR spectroscopy in clinical research', Acta Radiologica, Vol. 35, pp. 96-116, 1994
3 GK Radda, B Rajagopalan, DJ Taylor, 'Biochemistry in vivo: an appraisal of clinical magnetic resonance spectroscopy', Magn Reson Quart, Vol. 5, pp. 122-151, 1989
4 이정희, 최충곤, 김상태 외, 'Localized single voxel 1H MR spectroscopy toward routine clinical use', 대한방사선의학회, 제34호 185-191쪽, 1996년
5 최보영, 'Magnetic Resonance Spectroscopy in Radiology', 한국의학물리학회지, 제 3호, 33-42쪽, 1992년
6 최보영, 'In vivo NMR spectroscopy', 화학세계, 제35호 64-65쪽, 1995년
7 최보영, 서태석, 박용휘 외, 'In vivo 1H MR spectroscopy of human brain in six normal volunteers', 대한방사선의학회지, 제29호, 853-860쪽, 1993년
8 Timo Schirmer, Dorothee P.Auer, 'On the reliability of quantitative clinical magnetic resonance spectroscopy of the human brain', NMR in Biomedicine, Vol. 13, pp. 28-36, 2000   DOI   ScienceOn
9 B Ross, 'The biochernistry of living tissues: examination by MRS', NMR in Biomedicine., Vol. 8, pp. 215-219, 1992   DOI   ScienceOn
10 이성우, 은충기, 문치웅, 공저, 최신자기공명영상학, 214-215쪽, 1998년
11 Spectroscopy Application Guide for Gyroscan ACS-NT R6 Release 6, Philips Medical System, pp. 161-162, 1998
12 B Ross, T Michaelis, 'Clinical applications of magnetic resonance spectroscopy', Magn Reson Quart, Vol. 10, pp. 191-247, 1994
13 PA Bottomley, 'Human in vivo NMR spectroscopy in diagnostic medicine: clinical tool or research probe?', Radiology, Vol. 170, pp. 1-15, 1989
14 Ross B, R Kreis, T Ernst, 'Clinical tools for the 90s: magnetic resonance spectroscopy and metabolite imaging', Eur J Radiology, Vol. 14, pp. 128-140, 1992   DOI   ScienceOn
15 MW Weiner, 'The promise of magnetic resonance spectroscopy for medical diagnosis', Invest Radiology, Vol. 23, pp. 253-261, 1998   DOI