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Development of DNA Sensor Using Magnetic Iron Oxide Nanoparticle  

Nam, Ki-Chang (Clinical Trials Center for Medical Devices, Severance Hospital)
Song, Kwang-Soup (School of Electronic Engineering, Kumoh National Institute of Technology)
Publication Information
Journal of the Institute of Electronics Engineers of Korea SC / v.48, no.6, 2011 , pp. 51-56 More about this Journal
Abstract
The surface of magnetic iron oxide nanoparticles (${\gamma}-Fe_2O_3$) is functionalized ($-NH_2$, -COOH) with bifunctional organic molecules and evaluated using FT-IR (Fourier transform infrared spectroscopy). We immobilize 21-base pair probe DNA and hybridize fluorescence-labeled (Cy5) target DNA onto the functionalized iron oxide nanoparticles. The fluorescence images obtained from a confocal microscopy show that the functionalized iron oxide nanoparticles should detect the hybridization of complementary and noncomplementary DNA.
Keywords
바이오센서;산화철 나노입자;표면 개질;기능성 유기 분자;DNA센서;
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Times Cited By KSCI : 1  (Citation Analysis)
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