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A new diagnostic method for diabetic neuropathy using $TcpO_2$  

Hong, Hyun-Ki (Graduate Program in Biomedical Engineering, Yonsei University)
Kim, Sung-Woo (Graduate Program in Biomedical Engineering, Yonsei University)
Nam, Ki-Chang (National Institute of Advanced Industrial Science and Technology)
Cha, Eun-Jong (Dept. of Biomedical Engineering, College of Medicine , Chungbuk National University)
Kim, Deok-Won (Dept. of Medical Engineering, College of Medicine , Yonsei University)
Publication Information
Journal of the Institute of Electronics Engineers of Korea SC / v.44, no.3, 2007 , pp. 1-8 More about this Journal
Abstract
PDiabetic neuropathy is one of the most common diabetes related complications including diabetic nephropathy and retinopahty. In clinical practices, nerve conduction velocity (NCV) has been used as a standard method for diagnosing diabetic neuropathy. However, it applies maximum current of 100mA to nerves causing stress and pain to patients. In this study, as a non-invasive method, $TcpO_2$ was utilized to investigate the difference and relationship between $TcpO_2$ and $SpO_2$ of normal and diabetic neuropathy subjects. In addition, a new method of diagnosing diabetic neuropathy using $TcpO_2$ is suggested. 50 normal subjects and 50 diabetic patients with neuropathy diagnosed by NCV participated in this study. Parameters used in this study were $TcpO_2$, $TcpCO_2$, and $SpO_2$. As a result of the $TcpO_2$ measurements, statistical significances were found from $TcpO_2$ of hands and feet from normal and patients group(p<0.01). $SpO_2$ measured from index finger of normal and patient groups showed no statistical significance(p>0.05). On the other hand, $SpO_2$ measured from great toes of normal and patient groups showed statistical significance(p<0.01). Correlation coefficient between $SpO_2$ of finger and $TcpO_2$ of hand was 0.400 (p<0.01) and $SpO_2$ of toe and $TcpO_2$ of foot was 0.471(p<0.01). Both correlation values were statistically significant. Sensitivities and specificities of the $TcpO_2$ method were found to be 66 % and 92 %, respectively. If the suggested $TcpO_2$ method is used periodically, prevention and early diagnosis of diabetic neuropathy would be possible.
Keywords
Neuropathy; $TcpO_2$; $TcpCO_2$; $SpO_2$; NCV;
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