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Basic Investigation for the Won-invasive Measurement of Blood Glucose Concentrations by Millimeter Waves  

Kim Dong Kyun (MEMS Lab., Samsung Advanced)
Won Jong Hwa (MEMS Lab., Samsung Advanced)
Potapov Sergey N. (MEMS Lab., Samsung Advanced)
Meriakri Viacheslav V. (Lab. of Millimeter and Submillimeter Measurement and Spectroscopy, IRE RAS)
Chigryai Evgenii E. (Lab. of Millimeter and Submillimeter Measurement and Spectroscopy, IRE RAS)
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Abstract
As a basic research for the development of a non-invasive blood glucose sensor using millimeter waves, we have presented a method for measuring the dielectric properties of high loss dielectrics, based on the reflection method, and investigated the variation of the dielectric properties of glucose-water and glucose -0.9% NaCl solutions in the 10~90 GHz range. In the proposed method, a minimal reflection condition is formed by placing a specially-chosen low-loss plane-parallel plate in front of a high-loss medium under test at a given frequency range. Using the minimal power reflection coefficient and the corresponding frequency at this condition, tile dielectric properties of the medium can be determined. The measured results on pure water have shown the adequacy of the proposed method. The measured results on glucose-water and glucose -0.9% NaCl solutions in the 10~90 GHz range showed that the variations of the dielectric properties of glucose solutions according to the change of their glucose concentration were maximum in the 30~45 GHz range. From these facts we concluded that the variation of about 3 mole/L in the glucose solutions must be distinguished With the measurement accuracies of ±0.1 dB and ±0.01 GHz.
Keywords
무혈 혈당 측정;글루코오스 용액;유전특성;밀리미터파;최소반사조건;
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1 T. Matsuhita, M. Yamamoto, and Y. Nikawa, 'Basic Study on Non-invasive Monitoring of Blood Sugar Level by Measuring Transmission Coefficient in Millimeter Waves,' Transactions of the Institute of Electronics, Information and Communication Engineers C, Vol. J84-C, no. 6, pp. 527-530, 2001
2 R. W. Waynant and V. M. Chenault, 'Overview of Non-Invasive Fluid Glucose Measurement Using Optical Techniques to Maintain Glucose Control in Diabetes Mellitus,' LEOS newsletter, Vol. 12, no. 2, pp. 3-6, April 1998
3 A. Caduff, R. Dewarrat, E. Hirt, C. Kapitza and L. Heinemann, 'Non-invasive, Continuous Glucose Monitoring System based on Impedance Spectroscopy - A Proof of Concept Study,' Second Annual Diabetes Technology Meeting, Atlanta, USA, October 2002
4 R. Olmi, M. Bini, A. Ignesti, and C. Riminesi, 'Non-destructive permittivity measurement of solid materials,' Meas. Sci. Technol., Vol. 11, no. 11, pp. 1623-1629, 2000   DOI   ScienceOn
5 A. Saito, O. Miyawaki, and K. Nakamura, 'Dielectric Relaxation of Aqueous Solution with Low-molecular-weight Nonelectrolytes and Its Relationship with Solution Structure,' Biosci. Biotech. Biochem., Vol. 61, no. 11, pp, 1831-1835, 1997   DOI
6 M. Born and E. Wolf, 'Principles of Optics,' Pergamon Press. 1968
7 Y. Nikawa and D. Someya, 'Non-invasive Measurement of Blood Sugar Level by Millimeter Waves,' 2001 IEEE MTT-S International Microwave Symposium Digest, Vol. 1, pp. 171-174, 2001   DOI
8 J. Liebe. A. G. A. Hufford and T. Manabe, 'A model for the complex permittivity of water at frequencies below 1THz,' Int. J. of Infrared and Millimeter Waves, Vol. 12, no. 7, pp. 659-675, 1991   DOI
9 V. V. Meriakri, I. P. Nikitin, and E. E. Chigrai, 'Monitoring the water content of media and materials with millimeter waves,' Radio and Communications Technology (USSR), Vol. 1, no. 2, pp. 92-96, 1996