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http://dx.doi.org/10.5370/KIEE.2014.63.7.950

Design of Drug Treatment for HIV Infected Patients: Disturbance Observer based Control Technique  

Lee, Beom-Jin (Dept. of Electrical Engineering, Soongsil University)
Jo, Nam-Hoon (Dept. of Electrical Engineering, Soongsil University)
Publication Information
The Transactions of The Korean Institute of Electrical Engineers / v.63, no.7, 2014 , pp. 950-955 More about this Journal
Abstract
In this paper, we propose a drug treatment protocol for the three state HIV infection model that explicitly includes the concentration of healthy T cells, infected T cells, and HIV. While most of the previous methods are not able to achieve the treatment goal in the presence of modelling errors, the proposed method is designed so as to compensate for the model uncertainties. Based on the Jacobain linearization of nonlinear HIV infection model, disturbance observer(DOB) based control is employed to design the drug treatment for the HIV patients. Computer simulation is carried out for nonlinear model in order to compare the performance of the proposed method with that of the conventional technique. The simulation results show that, in the presence of parameter uncertainties, the substantial improvement in the performance can be achieved by the proposed DOB controller.
Keywords
HIV infection model; Disturbance observer; Modelling error; Q filter;
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1 C. A. Janeway, Immunobiology: The immune system in health and disease, 6th Ed., Garland Pub, 2004.
2 Dr Pedram Sendi, Andrew J. Palmer, Amiram Gafni, Manuel Battegay, "Highly active antiretroviral therapy", PharmacoEconomics, Vol. 19, No. 7, pp. 709-713, 2001.   DOI   ScienceOn
3 I. Craig, X. Xia, "Can HIV/AIDS be controlled ?", IEEE Control Systems Magazine. vol. 25, pp. 80-83, 2005.   DOI   ScienceOn
4 S. Ge, Z. Tian, T. Lee, "Nonlinear control of a dynamic model of hiv-1", IEEE Transactions on Biomedical Engineering, vol. 52, no. 3, pp. 353-361, 2005.   DOI   ScienceOn
5 R. Zurakowski, A. Teel, "A model predictive control based scheduling method for hiv therapy", Journal of Theoretical Biology, vol. 238, no. 2, pp. 368-382, 2006.   DOI   ScienceOn
6 M. Barao, J. Lemos, "Nonlinear control of hiv-1 infection with a singular perturbation model", Biomedical Signal Processing and Control, vol. 2, no. 3, pp. 248-257, 2007.   DOI   ScienceOn
7 H. Shim, and Nam H. Jo, "An almost necessary and sufficient conditions for robust stability of closed-loop systems with disturbance observer", Automatica, Vol. 45, No. 1, pp. 296-299, 2009.   DOI   ScienceOn
8 S.K. Stanley, "Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents", Morbidity and Mortality Weekly Report, vol. 47, no. 5, pp. 39-41, 1998.
9 Y. Choi, K. Yang, W.K. Chung, H.R. Kim, and I.H. Suh, "On the robustness and performance of disturbance observers for second-order systems", IEEE Transactions on Automatic Control, vol. 48, pp. 315-320, 2003.   DOI   ScienceOn