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Increase in concentration of soluble HLA-G in high-quality embryos after intracytoplasmic sperm injection  

Heidari, Mohammad-Hassan (Department of Anatomy, Shahid Beheshti Medical University)
Novin, Marefat-Ghaffari (Department of Anatomy, Shahid Beheshti Medical University)
Ahmadi, Farzaneh (Department of Anatomy, Shahid Beheshti Medical University)
Khorshid, Mehran (Department of Anatomy, Shahid Beheshti Medical University)
Najafi, Tohid (Department of Anatomy, Shahid Beheshti Medical University)
Molouki, Aidin (Institute of Bioscience, UPM University)
Salehpour, Saghar (IVF Center, Taleghani Hospital)
Bandehpour, Mojgan (Cellular and Molecular Research, Shahid Beheshti Medical University)
Heidari, Matineh (Medical University of Tehran)
Sato, Eimi (Reproductive Laboratory, Tohoko University)
Publication Information
Anatomy and Cell Biology / v.44, no.4, 2011 , pp. 331-336 More about this Journal
Abstract
Non-invasive methods are normally preferred to conventional invasive methods when selecting suitable embryos to improve pregnancy rates after assisted reproduction techniques. One of the most recognized non-invasive methods is to examine the supernatants of embryo culture media. Soluble human leukocyte antigen, class I, G (sHLA-G) antigen is a non-classical class I molecule that has been widely considered as a marker of pregnancy failure or implantation success. In the current study of some Iranian patients, we examined the concentration of sHLA-G at different time points after intracytoplasmic sperm injection and compared the rates to the morphology and quality of the selected embryos. We showed that the concentration of sHLA-G increases over time in high-quality embryos. We conclude that there is a positive relationship between morphology, quality, and sHLA-G concentration. We suggest that this relationship can be used to increase the chance of a successful pregnancy.
Keywords
HLA antigen; Assisted reproductive techniques; Intracytoplasmic sperm injections;
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