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http://dx.doi.org/10.5115/acb.2010.43.4.332

Expression of ErbB4 in the apoptotic neurons of Alzheimer's disease brain  

Woo, Ran-Sook (Department of Anatomy and Neuroscience, College of Medicine, Eulji University)
Lee, Ji-Hye (Department of Anatomy and Neuroscience, College of Medicine, Eulji University)
Yu, Ha-Nul (Department of Anatomy and Neuroscience, College of Medicine, Eulji University)
Song, Dae-Yong (Department of Anatomy and Neuroscience, College of Medicine, Eulji University)
Baik, Tai-Kyoung (Department of Anatomy and Neuroscience, College of Medicine, Eulji University)
Publication Information
Anatomy and Cell Biology / v.43, no.4, 2010 , pp. 332-339 More about this Journal
Abstract
Neuregulin-1 (NRG1) signaling participates in the synaptic plasticity, maintenance or regulation of adult brain. Although ErbB4, a key NRG1 receptor, is expressed in multiple regions in the adult animal brain, little is known about its localization in Alzheimer’s disease (AD) brains. We previously reported that ErbB4 immunoreactivity showed regional difference in the hippocampus of age-matched control. In the present paper, immunohistochemical characterization of the distribution of ErbB4 receptor in the hippocampus relative to pathology staging were performed in age-matched control (Braak stage 0, n=6) and AD (Braak stage I/V, n=10). Here, we found that ErbB4 immunoreactivity was significantly increased in apoptotic hippocampal pyramidal neurons in the brains of AD patients, compared to those of age-matched control subjects. In AD brains, ErbB4 immunoreactivity was demonstrated to colocalize with the apoptotic signal Bax in apoptotic hippocampal pyramidal neurons. These results suggest that up-regulation of ErbB4 immunoreactivity in apoptotic neuron may involve in the progression of pathology of AD.
Keywords
Alzheimer's disease; ErbB4 receptor; Bax; Apoptosis; Neurodegeneration;
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1 Stankovic K, Rio C, Xia A, et al. (2004). Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear. J Neurosci 24: 8651-8661   DOI   ScienceOn
2 Zhang L, Fletcher-Turner A, Marchionni MA, et al. (2004). Neurotrophic and neuroprotective effects of the neuregulin glial growth factor-2 on dopaminergic neurons in rat primary midbrain cultures. J Neurochem 91: 1358-1368   DOI   ScienceOn
3 Clementi ME, Pezzotti M, Orsini F, et al. (2006). Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35. Biochem Biophys Res Commun 342: 206-213   DOI   ScienceOn
4 Law AJ, Shannon Weickert C, Hyde TM, Kleinman JE, Harrison PJ. (2004). Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain. Neuroscience 127: 125-136   DOI   ScienceOn
5 Lukiw WJ, Bazan NG. (2006). Survival signalling in Alzheimer's disease. Biochem Soc Trans 34: 1277-1282   DOI   ScienceOn
6 Shyu WC, Lin SZ, Chiang MF, Yang HI, Thajeb P, Li H. (2004). Neuregulin-1 reduces ischemia-induced brain damage in rats. Neurobiol Aging 25: 935-944   DOI   ScienceOn
7 Mattson MP, Meffert MK. (2006). Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ 13: 852-860   DOI   ScienceOn
8 Ricart K, J Pearson R Jr, Viera L, et al. (2006). Interactions between beta-neuregulin and neurotrophins in motor neuron apoptosis. J Neurochem 97: 222-233   DOI   ScienceOn
9 Woo RS, Li XM, Tao Y, et al. (2007). Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54: 599-610   DOI   ScienceOn
10 Sathasivam S, Ince PG, Shaw PJ. (2001). Apoptosis in amyotrophic lateral sclerosis: a review of the evidence. Neuropathol Appl Neurobiol 27: 257-274   DOI   ScienceOn
11 Terry RD, Masliah E, Salmon DP, et al. (1991). Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580   DOI   ScienceOn
12 Meyer D, Birchmeier C. (1995). Multiple essential functions of neuregulin in development. Nature 378: 386-390   DOI   ScienceOn
13 Lee HJ, Jung KM, Huang YZ, et al. (2002). Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4. J Biol Chem 277: 6318-6323   DOI   ScienceOn
14 Murata K, Dalakas MC. (1999). Expression of the costimulatory molecule BB-1, the ligands CTLA-4 and CD28, and their mRNA in inflammatory myopathies. Am J Pathol 155: 453-460   DOI   ScienceOn
15 Ni CY, Murphy MP, Golde TE, Carpenter G. (2001). gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294: 2179-2181   DOI   ScienceOn
16 Li Y, Xu Z, Ford GD, et al. (2007b). Neuroprotection by neuregulin-1 in a rat model of permanent focal cerebral ischemia. Brain Res 1184: 277-283   DOI   ScienceOn
17 Marchionni MA, Goodearl AD, Chen MS, et al. (1993). Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362: 312-318   DOI   ScienceOn
18 Mattson MP. (2004). Pathways towards and away from Alzheimer's disease. Nature 430: 631-639   DOI   ScienceOn
19 Gonatas NK, Anderson W, Evangelista I. (1967). The contribution of altered synapses in the senile plaque: an electron microscopic study in Alzheimer's dementia. J Neuropathol Exp Neurol 26: 25-39   DOI
20 Huang YZ, Won S, Ali DW, et al. (2000). Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26: 443-455   DOI   ScienceOn
21 Li B, Woo RS, Mei L, Malinow R. (2007a). The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity. Neuron 54: 583-597   DOI   ScienceOn
22 Li BS, Ma W, Jaffe H, et al. (2003). Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J Biol Chem 278: 35702-35709   DOI   ScienceOn
23 Campbell SK, Switzer RC, Martin TL. (1987). Alzheimers plaques and tangles: a controled and enhanced silver staining method. In Proceeding Soc Neurosci 678
24 Ezaki T. (2000). Antigen retrieval on formaldehyde-fixed paraffin sections: its potential drawbacks and optimization for double immunostaining. Micron 31: 639-649   DOI   ScienceOn
25 Garcia RA, Vasudevan K, Buonanno A. (2000). The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci U S A 97: 3596-3601   DOI   ScienceOn
26 Goldshmit Y, Erlich S, Pinkas-Kramarski R. (2001). Neuregulin rescues PC12-ErbB4 cells from cell death induced by H(2)O(2). Regulation of reactive oxygen species levels by phosphatidylinositol 3-kinase. J Biol Chem 276: 46379-46385   DOI   ScienceOn
27 Croslan DR, Schoell MC, Ford GD, et al. (2008). Neuroprotective effects of neuregulin-1 on B35 neuronal cells following ischemia. Brain Res 1210: 39-47   DOI   ScienceOn
28 Cutler RG, Kelly J, Storie K, et al. (2004). Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci USA 101: 2070-2075   DOI   ScienceOn
29 Di Segni A, Shaharabani E, Stein R, Pinkas-Kramarski R. (2005). Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: involvement of PI3K and PKC. J Mol Neurosci 26: 57-69   DOI   ScienceOn
30 Braak H, Braak E. (1991). Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239-259   DOI   ScienceOn
31 Chaudhury AR, Gerecke KM, Wyss JM, Morgan DG, Gordon MN, Carroll SL. (2003). Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease. J Neuropathol Exp Neurol 62: 42-54   DOI