Browse > Article
http://dx.doi.org/10.5115/acb.2010.43.4.317

Lipoic acid suppresses compound 48/80-induced anaphylaxis-like reaction  

Choi, Yun-Ho (Department of Anatomy, Chonbuk National University Medical School, Institute for Medical Sciences, Chonbuk National University)
Chai, Ok-Hee (Department of Anatomy, Chonbuk National University Medical School, Institute for Medical Sciences, Chonbuk National University)
Han, Eui-Hyeog (Department of Anatomy, Chonbuk National University Medical School, Institute for Medical Sciences, Chonbuk National University)
Choi, Su-Young (Department of Anatomy, Chonbuk National University Medical School, Institute for Medical Sciences, Chonbuk National University)
Kim, Hyoung-Tae (Department of Anatomy, Chonbuk National University Medical School, Institute for Medical Sciences, Chonbuk National University)
Song, Chang-Ho (Department of Anatomy, Chonbuk National University Medical School, Institute for Medical Sciences, Chonbuk National University)
Publication Information
Anatomy and Cell Biology / v.43, no.4, 2010 , pp. 317-324 More about this Journal
Abstract
Alpha-lipoic acid (LA), a naturally occurring dithiol compound, is an essential cofactor in metabolic reactions involved in energy utilization. LA improves glycemic control, reduces diabetic polyneuropathies, atherosclerosis, and allergic inflammation. The effects of LA on mast cell-mediated anaphylactic reactions, however, are unknown. LA dose-dependently inhibited systemic and passive cutaneous anaphylaxis-like reactions in mice induced by compound 48/80, a condensation product of N-methyl-p-methoxyphenethylamine and formaldehyde. Pretreatment with LA, prior to induction of the systemic anaphylaxis-like reaction with compound 48/80, reduced plasma histamine levels in a dose-dependent manner. In our in vitro study, LA decreased histamine release from rat peritoneal mast cells (RPMCs) triggered by compound 48/80. Moreover, an increase in calcium uptake activated by compound 48/80 was inhibited by LA. LA also significantly elevated intracellular cyclic adenosine-3',5' monophosphate (cAMP) levels in RPMCs. This inhibition of mediator release from RPMCs may be due to inhibition of calcium uptake and augmentation of intracellular cAMP levels. Based on these results, we suggest that LA may be a potential remedy for allergy-related diseases.
Keywords
Mast cells; Immediate-type hypersensitivity; Histamine; Calcium; cAMP;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Fukuishi N, Sakaguchi M, Matsuura S, Nakagawa C, Akagi R, Akagi M. (1997). The mechanisms of compound 48/80-induced superoxide generation mediated by A-kinase in rat peritoneal mast cells. Biochem Mol Med 61: 107-113   DOI   ScienceOn
2 Pearce FL, Ennis M, Truneh A, White JR. (1981). Role of intra- and extracellular calcium in histamine release from rat peritoneal mast cells. Agents Actions 11: 51-54   DOI   ScienceOn
3 White JR, Ishizaka T, Ishizaka K, Sha'afi R. (1984). Direct demonstration of increased intracellular concentration of free calcium as measured by quin-2 in stimulated rat peritoneal mast cell. Proc Natl Acad Sci U S A 81: 3978-3982   DOI   ScienceOn
4 Akagi M, Katakuse Y, Fukuishi N, Kan T, Akagi R. (1994). Superoxide anion-induced histamine release from rat peritoneal mast cells. Biol Pharm Bull 17: 732-734   DOI   ScienceOn
5 Weston MC, Peachell PT. (1998). Regulation of human mast cell and basophil function by cAMP. Gen Pharmacol 31: 715-719   DOI   ScienceOn
6 Yoshii N, Mio M, Tasaka K. (1988). Ca uptake and Ca releasing properties of the endoplasmic reticulum in rat peritoneal mast cells. Immunopharmacology 16: 107-113   DOI   ScienceOn
7 Yoshimura T, Hamaguchi E, Usami E, et al. (2004). Increased in vitro release of interferon-gamma from ampicillin-stimulated peripheral blood mononuclear cells in Stevens-Johnson syndrome. Biol Pharm Bull 27: 929-931   DOI   ScienceOn
8 Izushi K, Tasaka K. (1989). Histamine release from beta-escin-permeabilized rat peritoneal mast cells and its inhibition by intracellular Ca2+ blockers, calmodulin inhibitors and cAMP. Immunopharmacology 18: 177-186   DOI   ScienceOn
9 Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. (2009). Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta 1790: 1149-1160   DOI   ScienceOn
10 Shinmei Y, Hossen MA, Okihara K, Sugimoto H, Yamada H, Kamei C. (2004). Effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in mice. Int Immunopharmacol 4: 1431-1436   DOI   ScienceOn
11 Martynova MG, Bystrova OA, Moiseeva OM, Evdonin AL, Kondratov KA, Medvedeva ND. (2005). The presence of ANP in rat peritoneal mast cells. Cell Res 15: 811-816   DOI   ScienceOn
12 Nishikawa H, Kitani S. (2008). Tea catechins have dual effect on mast cell degranulation induced by compound 48/80. Int Immunopharmacol 8: 1207-1215   DOI   ScienceOn
13 Peachell PT, MacGlashan DW Jr, Lichtenstein LM, Schleimer RP. (1988). Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate. J Immunol 140: 571-579
14 Choi YH, Yan GH, Chai OH, et al. (2006). Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus. Biol Pharm Bull 29: 1360-1365   DOI   ScienceOn
15 Galli SJ, Tsai M. (2010). Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. Eur J Immunol 40: 1843-1851   DOI   ScienceOn
16 Galli SJ, Tsai M, Piliponsky AM. (2008). The development of allergic inflammation. Nature 454: 445-454   DOI   ScienceOn
17 Hoth M, Penner R. (1993). Calcium release-activated calcium current in rat mast cells. J Physiol 465: 359-386   DOI
18 Carvalho RF, Nilsson G, Harvima IT. (2010). Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation. Exp Dermatol 19: 117-122   DOI   ScienceOn
19 Cho YS, Lee J, Lee TH, et al. (2004). alpha-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J Allergy Clin Immunol 114: 429-435   DOI   ScienceOn
20 Bilska A, Wlodek L. (2005). Lipoic acid - the drug of the future? Pharmacol Rep 57: 570-577
21 Tasaka K, Mio M, Okamoto M. (1986). Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann Allergy 56: 464-469