Browse > Article
http://dx.doi.org/10.5115/acb.2010.43.2.125

Effects of hyaluronan on carrageenan-induced synovitis in rat TMJ  

Lee, Min-Jung (Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University)
Han, Kook-Jin (Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University)
Kwon, Hyuk-Jae (Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University)
Jung, Han-Sung (Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University)
Cho, Sung-Won (Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University)
Publication Information
Anatomy and Cell Biology / v.43, no.2, 2010 , pp. 125-131 More about this Journal
Abstract
Nitric oxide is one of many proinflammatory mediators that are involved in temporomandibular joint (TMJ) inflammatory disorder and is synthesized by inducible nitric oxide synthase (iNOS). iNOS is transcriptionally regulated by nuclear factor-${\kappa}B$ (NF-${\kappa}B$B) in cases of infl ammation, proliferation, and apoptosis. It has also been reported that nitric oxide is positively regulated by carrageenan and negatively regulated by hyaluronan in the knee joint. The aim of this study was to histologically evaluate how inflammation and cell proliferation of the synovial membrane are affected by the exogenous administration of carrageenan and hyaluronan in the rat TMJ by investigating iNOS, NF-${\kappa}B$, and anti proliferating cell nuclear antigen (PCNA) immunoreactivity. As results, immunoreactive cells to iNOS, NF-${\kappa}B$, and PCNA were normally localized only in the synovial membrane of wild type TMJs. The numbers of immunoreactive cells were extensively larger in the carrageenan-injected synovial membranes exhibiting excessive folding, and smaller in the hyaluronan-injected synovial membranes showing a few folds. These results indicate that a carrageenan injection induced inflammation and cell proliferation especially in the synovial membrane and that hyaluronan relieved the inflammation by decreasing inflammatory molecules in the synovial membrane.
Keywords
Hyaluronan; Carrageenan; TMJ; iNOS; NF-${\kappa}B$;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Yamasaki S, Kawakami A, Nakashima T, et al. (2001). Importance of NF-kappaB in rheumatoid synovial tissues: in situ NF-kappaB expression and in vitro study using cultured synovial cells. Ann Rheum Dis 60: 678-684   DOI   ScienceOn
2 Yamaza T, Masuda K, Atsuta I, Nishijima K, Kido MA, Tanaka T. (2004). Oxidative stress induced DNA damage in the synovial cells of the temporomandibular joint in the rat. J Dent Res 83: 619-624   DOI   ScienceOn
3 Yamaza T, Masuda KF, Tsukiyama Y, et al. (2003). NF-$\kappa$B activation and iNOS expression in the synovial membrane of rat temporomandibular joints after induced synovitis. J Dent Res 82: 183-188   DOI   ScienceOn
4 Takahashi T, Homma H, Nagai H, et al. (2003). Specific expression of inducible nitric oxide synthase in the synovium of the diseased temporomandibular joint. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95: 174-181   DOI   ScienceOn
5 Takahashi T, Kondoh T, Kamei K, et al. (1996). Elevated levels of nitric oxide in synovial fluid from patients with temporomandibular disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82: 505-509   DOI   ScienceOn
6 Nozawa-Inoue K, Amizuka N, Ikeda N, Suzuki A, Kawano Y, Maeda T. (2003). Synovial membrane in the temporomandibular joint--its morphology, function and development. Arch Histol Cytol 66: 289-306   DOI   ScienceOn
7 Tonussi CR, Ferreira SH. (1999). Tumor necrosis factor-alpha mediates carrageenan-induced knee joint incapacitation and also trigger overt ociception in previously inflamed rat knee joints. Pain 82: 81-87   DOI   ScienceOn
8 Tzaribachev N, Fritz J, Horger M. (2009). Spectrum of magnetic resonance imaging appearances of juvenile Temporomandibular Joints (TMJ) in non-rheumatic children. Acta Radiologica 50: 1182-1186   DOI   ScienceOn
9 Wilcox DK, Higgins J, Bertram TA. (1992). Colonic epithelial cell proliferation in a rat model of nongenotoxin-induced colonic neoplasia. Laboratory Investigation 67: 405-411
10 Pelletier JP, Lascau-Coman V, Jovanovic D, et al. (1999). Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. J Rheumatol 26: 2002-2014
11 Lawand NB, McNearney T, Westlund KN. (2000). Amino acid release into the knee joint: key role in nociception and inflammation. Pain 86: 69-74   DOI   ScienceOn
12 Radhakrishnan R, Moore SA, Sluka KA. (2003). Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats. Pain 104: 567-577   DOI   ScienceOn
13 Singh R, Ahmed S, Islam N, Goldberg VM, Haqqi TM. (2002). Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB. Arthritis Rheum 46: 2079-2086   DOI   ScienceOn
14 Suzuki J, Na HK, Upham BL, Chang CC, Trosko JE. (2000). Lamda-carrageenan-induced inhibition of gap-junctional intercellular communication in rat liver epithelial cells. Nutrition and Cancer 36: 122-128   DOI   ScienceOn
15 Lundeberg T, Alstergren P, Appelgren A, Appelgren B, Carleson J, Kopp S. (1996). A model for experimentally induced temporomadubular joint arthritis in rats: effects of carrageenan on europeptide like immunoreactivity. Neuropeptides 30: 37-44   DOI   ScienceOn
16 Feldmann M, Andreakos E, Smith C, et al. (2002). Is NF-kappaB a useful therapeutic target in rheumatoid arthritis? Ann Rheum Dis 61 Suppl 2: ii13-18   DOI
17 Makarov SS. (2001). NF-kappa B in rheumatoid arthritis: a pivotal regulator of infl ammation, hyperplasia, and tissue destruction. Arthritis Res 3: 200-206   DOI   ScienceOn
18 Min HJ, Lee MJ, Kim JY, et al. (2007) Alteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy. Oral Diseases 13: 220-227   DOI   ScienceOn
19 Moncada S. (1992). The 1991 Ulf von Euler Lecture. The L-arginine: nitric oxide pathway. Acta Physiol Scand 145: 201-227   DOI   ScienceOn
20 Hansra P, Moran EL, Fornasier VL, Bogoch ER. (2000). Carrageenan-induced arthritis in the rat. Inflammation 24: 141-155   DOI   ScienceOn
21 Cuzzocrea S, Tan DX, Costantino G, Mazzon E, Caputi AP, Reiter RJ. (1999). The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat. FASEB J 13: 1930-1938
22 Homma H, Takahasi T, Seki H, Ohtani N, Kondon T, Fukuda M. (2001). Immunohistochemical localization of inducible nitric oxide synthase in synovial tissue of human temporomandibular joints with internal derangement. Arch Oral Biol 46: 93-97   DOI   ScienceOn
23 Kishimoto G, Hosomichi J, Muramoto T, Kanno Z, Soma K. (2007). Influence of estrogen cycle on temporomandibular joint synovial membrane in rat with deviated mandible. J Med Dent Sci. 54: 79-85
24 Kopp S, Akerman S, Nilner M. (1991). Short-term effects of intra-articular sodium hyaluronate, glucocorticoid and saline injections on rheumatoid arthritis of the temporomandibular joint. J Craniomandib Disord 5: 231-238
25 Diaz-Gallego L, Prieto JG, Coronel P, Gamazo LE, Gimeno M, Alvarez AI. (2005). Apoptosis and nitric oxide in an experimental model of osteoarthritis in rabbit after hyaluronic acid treatment. J Orthop Res 23: 1370-1376.   DOI
26 Egan CG, Lockhart JC, Ferrell WR, Day SM, McLean JS. (2002). Pathophysiological basis of acute inflammatory hyperaemia in the rat knee: roles of cyclo-oxygenase-1 and -2. J Physiol 539(Pt 2): 579-587   DOI   ScienceOn
27 Farrell AJ. (1992). Increased concentration of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic disease. Ann Rheum Dis 51: 1219-1222   DOI   ScienceOn
28 Al-Majed AA, Khattab M, Raza M, Al-Shabanah OA, Mostafa AM. (2003). Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute infl ammation in rats: the role of nitric oxide. Inflamm Res 52: 378-382   DOI   ScienceOn
29 Calvert RJ, Reicks M. (1988). Alterations in colonic thymidine kinase enzyme activity induced by consumption of various dietary fibres. Proc Soc Exp Biol Med 189: 45-51   DOI
30 Collantes E, Valle Blazquez M, Mazorra V, Macho A, Aranda E, Munoz E. (1998). Nuclear factor-kappa B activity in T cells from patients with rheumatic diseases: a preliminary report. Ann Rheum Dis 57: 738-741   DOI   ScienceOn
31 Cuzzocrea S, Mazzon E, Calabro G, et al. (2000). Inducible nitric oxide synthase-knockout mice exhibit resistance to pleurisy and lung injury caused by carrageenan. Am J Respir Crit Care Med 162: 1859-1866   DOI   ScienceOn