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http://dx.doi.org/10.5115/acb.2010.43.1.64

Immunohistochemical study on the expre ssion of calcium binding proteins (calbindin-D28k, calretinin, and parvalbumin) in the cerebellum of the nNOS knock-out(-/-) mice  

Lee, Jae-Chul (Department of Anatomy, Seoul National University College of Medicine)
Chung, Yoon-Hee (Chung-Ang University College of Medicine)
Cho, Yu-Jin (Department of Anatomy, Seoul National University College of Medicine)
Kim, Jan-Di (Department of Anatomy, Seoul National University College of Medicine)
Kim, Na-Hee (Department of Anatomy, Seoul National University College of Medicine)
Cha, Choong-Ik (Department of Anatomy, Seoul National University College of Medicine)
Joo, Kyeung-Min (Department of Anatomy, Seoul National University College of Medicine)
Publication Information
Anatomy and Cell Biology / v.43, no.1, 2010 , pp. 64-71 More about this Journal
Abstract
Nitric Oxide (NO) actively participates in the regulation of neuronal intracellular $Ca^{2+}$ levels by modulating the activity of various channels and receptors. To test the possibility that modulation of $Ca^{2+}$ buff er protein expression level by NO participates in this regulatory effect, we examined expression of calbindin-D28k, calretinin, and parvalbumin in the cerebellum of neuronal NO synthase knock-out ($nNOS^{(-/-)}$) mice using immunohistochemistry. We observed that in the cerebellar cortex of the $nNOS^{(-/-)}$ mice, expression of calbindin-D28k and parvalbumin were significantly increased while expression of calretinin was signifi cantly decreased. These results suggest another mechanism by which NO can participate in the regulation of $Ca^{2+}$ homeostasis.
Keywords
Calbindin-D28k; calretinin; parvalbumin; cerebellum; neuronal nitric oxide synthase (nNOS) knock-out (-/-) mice;
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