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http://dx.doi.org/10.4491/KSEE.2012.34.12.855

Research Trends for Nanotoxicity Using Soil Nematode Caenorhabditis elegans  

Kim, Shin Woong (Department of Environmental Science, Konkuk University)
Lee, Woo-Mi (Department of Environmental Science, Konkuk University)
An, Youn-Joo (Department of Environmental Science, Konkuk University)
Publication Information
Journal of Korean Society of Environmental Engineers / v.34, no.12, 2012 , pp. 855-862 More about this Journal
Abstract
Caenorhabditis elegans, a free-living nematode mainly found in the soil pore water, roles the critical function in trophic levels, energy flow, and decomposition in soil ecosystem. C. elegans is commonly used species to test soil toxicity. Recently, they are employed broadly as a test organism in nanotoxicology. In this study, a review of the toxicity of nanomaterials for C. elegans was presented based on SCI (E) papers. The nanotoxicity studies using C. elegans have been reported in 20 instances including the mechanism of toxicity. Most studies used K-medium, S-medium, and NGM (Nematode Growth Medium) plate as an exposure medium to test toxicity of nanoparticles. The effects observed include anti aging, phototoxicity, genotoxicity, and dermal effects on C. elegans exposed to nanoparticles. We found that the toxic mechanisms were related with various aspects such as lifespan abnormality, oxidative stress, distribution of particles on inter-organisms, and stress-related gene analysis. C. elegans has advantage to test toxicity of nanoparticles due to various cellular activities, full genome information, and easy observation of transparent body. C. elegans was considered to be a good test species to evaluate the nanotoxicity.
Keywords
Caenorhabditis elegans; Soil Nematode; Nanoparticle; Nanotoxicity;
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