1 |
Wang P, Xie ZH, Guo YJ, Zhao CP, Jiang H, Song Y, et al. VEGF-induced angiogenesis ameliorates the memory impairment in APP transgenic mouse model of Alzheimer's disease. Biochemical and Biophysical Research Communications. 2011;411(3):620-626. https://doi.org/10.1016/j.bbrc.2011.07.003
DOI
|
2 |
Lopez NE, Krzyzaniak MJ, Blow C, Putnam J, Ortiz-Pomales Y, Hageny AM, et al. Ghrelin prevents disruption of the blood-brain barrier after traumatic brain injury. Journal of Neurotrauma. 2012;29(2):385-393. https://doi.org/10.1089/neu.2011.2053
DOI
|
3 |
Mead R. The design of experiments: Statistical principles for practical applications. Cambridge: Cambridge University Press; 1990. p. 7-8.
|
4 |
Spence KW, Lippitt R. An experimental test of the sign-gestalt theory of trial and error learning. Journal of Experimental Psychology. 1946;36(6):491-502. https://doi.org/10.1037/h0062419
DOI
|
5 |
Morris RGM, Garrud P, Rawlins JNP, O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature. 1982;297(5868):681-683. https://doi.org/10.1038/297681a0
DOI
|
6 |
Venkat P, Chopp M, Chen J. Models and mechanisms of vascular dementia. Experimental Neurology. 2015;272:97-108. https://doi.org/10.1016/j.expneurol.2015.05.006
DOI
|
7 |
Kim Y, Kim S, Kim C, Sato T, Kojima M, Park S. Ghrelin is required for dietary restriction-induced enhancement of hippocampal neurogenesis: Lessons from ghrelin knockout mice. Endocrine Journal. 2015;62(3):269-275. https://doi.org/10.1507/endocrj.EJ14-0436
DOI
|
8 |
Hansen TK, Dall R, Hosoda H, Kojima M, Kangawa K, Christiansen JS, et al. Weight loss increases circulating levels of ghrelin in human obesity. Clinical Endocrinology. 2002;56(2):203-206. https://doi.org/10.1046/j.0300-0664.2001.01456.x
DOI
|
9 |
Harvey J. Leptin regulation of neuronal morphology and hippocampal synaptic function. Frontiers in Synaptic Neuroscience. 2013;5:3. https://doi.org/10.3389/fnsyn.2013.00003
DOI
|
10 |
Irving AJ, Harvey J. Leptin regulation of hippocampal synaptic function in health and disease. Philosophical Transactions of the Royal Society B: Biological Sciences. 2014;369(1633):20130155. https://doi.org/10.1098/rstb.2013.0155
DOI
|
11 |
Li E, Kim Y, Kim S, Park S. Ghrelin-induced hippocampal neurogenesis and enhancement of cognitive function are mediated independently of GH/IGF-1 axis: Lessons from the spontaneous dwarf rats. Endocrine Journal. 2013;60(9):1065-1075. https://doi.org/10.1507/endocrj.ej13-0045
DOI
|
12 |
Chen L, Xing T, Wang M, Miao Y, Tang M, Chen J, et al. Local infusion of ghrelin enhanced hippocampal synaptic plasticity and spatial memory through activation of phosphoinositide 3‐kinase in the dentate gyrus of adult rats. European Journal of Neuroscience. 2011;33(2):266-275. https://doi.org/10.1111/j.1460-9568.2010.07491.x
DOI
|
13 |
Innocenti GM. General organization of callosal connections in the cerebral cortex. In: Jones EG, Peters A, editors. Sensory-Motor Areas and Aspects of Cortical Connectivity. Boston (MA): Springer US; 1986. p. 291-353.
|
14 |
Wu XP, Gao YJ, Yang JL, Xu M, Sun DH. Quantitative measurement to evaluate morphological changes of the corpus callosum in patients with subcortical ischemic vascular dementia. Acta Radiologica. 2015;56(2):214-218. https://doi.org/10.1177/0284185114520863
DOI
|
15 |
Lee JY, Oh TH, Yune TY. Ghrelin inhibits hydrogen peroxide-induced apoptotic cell death of oligodendrocytes via ERK and p38MAPK signaling. Endocrinology. 2011;152(6):2377-2386. https://doi.org/10.1210/en.2011-0090
DOI
|
16 |
Jantaratnotai N, Ryu JK, Schwab C, McGeer PL, McLarnon JG. Comparison of vascular perturbations in an -injected animal model and in AD brain. International Journal of Alzheimer's Disease. 2011;2011:918280. https://doi.org/10.4061/2011/918280
DOI
|
17 |
Neto CJBF, Paganelli RA, Benetoli A, Lima KCM, Milani H. Permanent, 3-stage, 4-vessel occlusion as a model of chronic and progressive brain hypoperfusion in rats: A neurohistological and behavioral analysis. Behavioural Brain Research. 2005;160(2):312-322. https://doi.org/10.1016/j.bbr.2004.12.016
DOI
|
18 |
Iadecola C. The pathobiology of vascular dementia. Neuron. 2013;80(4):844-866. https://doi.org/10.1016/j.neuron.2013.10.008
DOI
|
19 |
Kalaria RN. The pathology and pathophysiology of vascular dementia. Neuropharmacology. 2018;134(B):226-239. https://doi.org/10.1016/j.neuropharm.2017.12.030
DOI
|
20 |
Ma X, Sun Z, Liu Y, Jia Y, Zhang B, Zhang J. Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia. Neural Regeneration Research. 2013;8(22):2050-2059. https://doi.org/10.3969/j.issn.1673-5374.2013.22.004
|
21 |
Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407(6801):249-257. https://doi.org/10.1038/35025220
DOI
|
22 |
Plate KH. Mechanisms of angiogenesis in the brain. Journal of Neuropathology and Experimental Neurology. 1999;58(4):313-320. https://doi.org/10.1097/00005072-199904000-00001
DOI
|
23 |
Fan Y, Yang GY. Therapeutic angiogenesis for brain ischemia: A brief review. Journal of Neuroimmune Pharmacology. 2007;2(3):284-289. https://doi.org/10.1007/s11481-007-9073-3
DOI
|
24 |
Pillai A, Mahadik SP. Differential effects of haloperidol and olanzapine on levels of vascular endothelial growth factor and angiogenesis in rat hippocampus. Schizophrenia Research. 2006;87(1-3):48-59. https://doi.org/10.1016/j.schres.2006.06.017
DOI
|
25 |
Shiojima I, Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circulation Research. 2002;90(12):1243-1250. https://doi.org/10.1161/01.res.0000022200.71892.9f
DOI
|
26 |
Chen J, Cui X, Zacharek A, Cui Y, Roberts C, Chopp M. White matter damage and the effect of matrix metalloproteinases in type 2 diabetic mice after stroke. Stroke. 2011;42(2):445-452. https://doi.org/10.1161/strokeaha.110.596486
DOI
|
27 |
Wang L, Chen Q, Li G, Ke D. Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways in rat cardiac microvascular endothelial cells. Peptides. 2012;33(1):92-100. https://doi.org/10.1016/j.peptides.2011.11.001
DOI
|
28 |
Chen X, Chen Q, Wang L, Li G. Ghrelin induces cell migration through GHSR1a-mediated PI3K/Akt/eNOS/NO signaling pathway in endothelial progenitor cells. Metabolism. 2013;62(5):743-752. https://doi.org/10.1016/j.metabol.2012.09.014
DOI
|
29 |
Rossi F, Castelli A, Bianco MJ, Bertone C, Brama M, Santiemma V. Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation. Peptides. 2008;29(11):2046-2051. https://doi.org/10.1016/j.peptides.2008.07.002
DOI
|
30 |
Candelario-Jalil E, Thompson J, Taheri S, Grossetete M, Adair JC, Edmonds E, et al. Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment. Stroke. 2011;42(5):1345-1350. https://doi.org/10.1161/strokeaha.110.600825
DOI
|
31 |
Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, et al. White matter lesions in an unselected cohort of the elderly: Astrocytic, microglial and oligodendrocyte precursor cell responses. Neuropathology and Applied Neurobiology. 2007;33(4):410-419. https://doi.org/10.1111/j.1365-2990.2007.00828.x
DOI
|
32 |
Baskys A, Hou AC. Vascular dementia: Pharmacological treatment approaches and perspectives. Clinical Interventions in Aging. 2007;2(3):327-335.
|
33 |
Park HR, Park M, Choi J, Park KY, Chung HY, Lee J. A high-fat diet impairs neurogenesis: Involvement of lipid peroxidation and brain-derived neurotrophic factor. Neuroscience Letters. 2010;482(3):235-239. https://doi.org/10.1016/j.neulet.2010.07.046
DOI
|
34 |
O'Brien JT, Thomas A. Vascular dementia. The Lancet. 2015;386(10004):1698-1706. https://doi.org/10.1016/S0140-6736(15)00463-8
DOI
|
35 |
Jiwa NS, Garrard P, Hainsworth AH. Experimental models of vascular dementia and vascular cognitive impairment: A systematic review. Journal of Neurochemistry. 2010;115(4):814-828. https://doi.org/10.1111/j.1471-4159.2010.06958.x
DOI
|
36 |
Olazarán J, Reisberg B, Clare L, Cruz I, Peña-Casanova J, del Ser T, et al. Nonpharmacological therapies in Alzheimer's disease: A systematic review of efficacy. Dementia and Geriatric Cognitive Disorders. 2010;30(2):161-178. https://doi.org/10.1159/000316119
DOI
|
37 |
Moon M, Kim S, Hwang L, Park S. Ghrelin regulates hippocampal neurogenesis in adult mice. Endocrine Journal. 2009;56(3):525-531. https://doi.org/10.1507/endocrj.K09E-089
DOI
|
38 |
Andrews ZB. The extra-hypothalamic actions of ghrelin on neuronal function. Trends in Neurosciences. 2011;34(1):31-40. https://doi.org/10.1016/j.tins.2010.10.001
DOI
|
39 |
Park S. Ghrelin. Endocrinology and Metabolism. 2010; 25(4):258-263. https://doi.org/10.3803/enm.2010.25.4.258
DOI
|
40 |
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-660. https://doi.org/10.1038/45230
DOI
|
41 |
Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, et al. Ghrelin controls hippocampal spine synapse density and memory performance. Nature Neuroscience. 2006;9(3):381-388. https://doi.org/10.1038/nn1656
DOI
|
42 |
Carlini VP, Varas MM, Cragnolini AB, Schiöth HB, Scimonelli TN, de Barioglio SR. Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin. Biochemical and Biophysical Research Communications. 2004;313(3):635-641. https://doi.org/10.1016/j.bbrc.2003.11.150
DOI
|
43 |
Liu Y, Chen L, Xu X, Vicaut E, Sercombe R. Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2. BMC Physiology. 2009;9:17. https://doi.org/10.1186/1472-6793-9-17
DOI
|
44 |
Miao Y, Xia Q, Hou Z, Zheng Y, Pan H, Zhu S. Ghrelin protects cortical neuron against focal ischemia/reperfusion in rats. Biochemical and Biophysical Research Communications. 2007;359(3):795-800. https://doi.org/10.1016/j.bbrc.2007.05.192
DOI
|
45 |
Liu Y, Wang PS, Xie D, Liu K, Chen L. Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chinese Journal of Physiology. 2006;49(5):244-250.
|