Browse > Article
http://dx.doi.org/10.4040/jkan.2014.44.4.371

Effects of Antioxidant on Reduction of Hindlimb Muscle Atrophy Induced by Cisplatin in Rats  

Kim, Jin Il (Department of Nursing, Christian College of Nursing)
Choe, Myoung-Ae (College of Nursing, Seoul National University.Oita University of Nursing and Health Sciences)
Publication Information
Journal of Korean Academy of Nursing / v.44, no.4, 2014 , pp. 371-380 More about this Journal
Abstract
Purpose: The purpose of this study was to examine the effects of Cu/Zn SOD on reduction of hindlimb muscular atrophy induced by cisplatin in rats. Methods: Forty-two rats were assigned to three groups; control group, Cisplatin (CDDP) group and cisplatin with Cu/Zn SOD (CDDP-SOD) group. At day 35 hindlimb muscles were dissected. Food intake, activity, withdrawal threshold, muscle weight, and Type I, II fiber cross-sectional area (CSA) of dissected muscles were measured. Relative SOD activity and expression of MHC and phosphorylated Akt, ERK were measured after dissection. Results: Muscle weight and Type I, II fiber CSA of hindlimb muscles in the CDDP group were significantly less than the control group. Muscle weight and Type I, II fiber CSA of hindlimb muscles, food intake, activity, and withdrawal thresholds of the CDDP-SOD group were significantly greater than the CDDP group. There were no significant differences in relative SOD activities of hindlimb muscles between the CDDP-SOD and CDDP groups. MHC expression and phosphorylated Akt, ERK of hindlimb muscles in the CDDP-SOD group were significantly greater than the CDDP group. Conclusion: Cu/Zn SOD attenuates hindlimb muscular atrophy induced by cisplatin through increased food intake and activity. Increment of phosphorylated Akt, ERK may relate to attenuation of hindlimb muscular atrophy.
Keywords
Antioxidant; Cisplatin; Rat; Muscular atrophy; Superoxide dismutase;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Hart PJ, Balbirnie MM, Ogihara NL, Nersissian AM, Weiss MS, Valentine JS, et al. A structure-based mechanism for copper-zinc superoxide dismutase. Biochemistry. 1999;38(7):2167-2178. http://dx.doi.org/10.1021/bi982284u   DOI   ScienceOn
2 Kim W, Kim DW, Yoo DY, Chung JY, Hwang IK, Won MH, et al. Neuroprotective effects of PEP-1-Cu,Zn-SOD against ischemic neuronal damage in the rabbit spinal cord. Neurochemical Research. 2012;37(2): 307-313. http://dx.doi.org/10.1007/s11064-011-0613-0   DOI   ScienceOn
3 Noshita N, Sugawara T, Lewen A, Hayashi T, Chan PH. Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice. Stroke. 2003;34(6):1513-1518. http://dx.doi.org/10.1161/01.str.0000072986.46924.f4   DOI   ScienceOn
4 Widegren U, Ryder JW, Zierath JR. Mitogen-activated protein kinase signal transduction in skeletal muscle: Effects of exercise and muscle contraction. Acta Physiologica Scandinavica. 2001;172(3):227-238. http://dx.doi.org/10.1046/j.1365-201x.2001.00855.x   DOI   ScienceOn
5 Baillet F, Housset M, Michelson AM, Puget K. Treatment of radiofibrosis with liposomal superoxide dismutase. Preliminary results of 50 cases. Free Radical Research Communications. 1986;1(6):387-394.   DOI
6 Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, et al. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/ Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nature Cell Biology. 2001;3(11):1009-1013. http://dx.doi.org/10.1038/ncb1101-1009   DOI   ScienceOn
7 Li G, Feng X, Wang S. Effects of Cu/Zn superoxide dismutase on strain injury-induced oxidative damage to skeletal muscle in rats. Physiological Research. 2005;54(2):193-199.
8 Mead R. The design of experiments : Statistical principles for practical applications. 9th ed.. Cambridge, UK: Cambridge University Press; 1988. 587.
9 Fanzani A, Zanola A, Rovetta F, Rossi S, Aleo MF. Cisplatin triggers atrophy of skeletal C2C12 myotubes via impairment of Akt signalling pathway and subsequent increment activity of proteasome and autophagy systems. Toxicology and Applied Pharmacology. 2011;250(3): 312-321. http://dx.doi.org/10.1016/j.taap.2010.11.003   DOI   ScienceOn
10 Caso G, Garlick PJ, Ballou LM, Vosswinkel JA, Gelato MC, McNurlan MA. The increase in human muscle protein synthesis induced by food intake is similar when assessed with the constant infusion and flooding techniques. The Journal of Nutrition. 2006;136(6):1504-1510.   DOI
11 Munoz KA, Aannestad A, Tischler ME, Henriksen EJ. Skeletal muscle protein content and synthesis after voluntary running and subsequent unweighting. Metabolism. 1994;43(8):994-999.   DOI   ScienceOn
12 Antolovich M, Prenzler PD, Patsalides E, McDonald S, Robards K. Methods for testing antioxidant activity. The Analyst. 2002;127(1):183-198.   DOI   ScienceOn
13 Zhang Y, Davis C, Sakellariou GK, Shi Y, Kayani AC, Pulliam D, et al. CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice. FASEB Journal. 2013;27(9):3536-3548. http://dx.doi.org/10.1096/fj.13-228130   DOI   ScienceOn
14 Tiidus PM, Bombardier E, Hidiroglou N, Madere R. Estrogen administration, postexercise tissue oxidative stress and vitamin C status in male rats. Canadian Journal of Physiology and Pharmacology. 1998;76(10-11):952-960.   DOI   ScienceOn
15 Rush JW, Green HJ, Maclean DA, Code LM. Oxidative stress and nitric oxide synthase in skeletal muscles of rats with post-infarction, compensated chronic heart failure. Acta Physiologica Scandinavica. 2005;185(3):211-218. http://dx.doi.org/10.1111/j.1365-201X.2005.01479.x   DOI   ScienceOn
16 Tominaga T, Hachiya M, Shibata T, Sakamoto Y, Taki K, Akashi M. Exogenously- added copper/zinc superoxide dismutase rescues damage of endothelial cells from lethal irradiation. Journal of Clinical Biochemistry and Nutrition. 2012;50(1):78-83. http://dx.doi.org/10.3164/jcbn.11-15
17 Salganik RI. The benefits and hazards of antioxidants: Controlling apoptosis and other protective mechanisms in cancer patients and the human population. Journal of the American College of Nutrition. 2001;20(5 Suppl):464S-472S.   DOI
18 Akan Z, Garip AI. Antioxidants may protect cancer cells from apoptosis signals and enhance cell viability. Asian Pacific Journal of Cancer Prevention. 2013;14(8):4611-4614.   DOI   ScienceOn
19 Decatris MP, Sundar S, O'Byrne KJ. Platinum-based chemotherapy in metastatic breast cancer: Current status. Cancer Treatment Reviews. 2004;30(1):53-81. http://dx.doi.org/10.1016/s0305-7372(03)00139-7   DOI   ScienceOn
20 Yakabi K, Sadakane C, Noguchi M, Ohno S, Ro S, Chinen K, et al. Reduced ghrelin secretion in the hypothalamus of rats due to cisplatin-induced anorexia. Endocrinology. 2010;151(8):3773-3782. http://dx.doi.org/10.1210/en.2010-0061   DOI   ScienceOn
21 Miller RP, Tadagavadi RK, Ramesh G, Reeves WB. Mechanisms of Cisplatin nephrotoxicity. Toxins. 2010;2(11):2490-2518. http://dx.doi.org/10.3390/toxins2112490   DOI
22 Yang GS, Choe MA. Effect of anorexia and neuropathic pain induced by cisplatin on hindlimb muscles of rat. Journal of Korean Academy of Nursing. 2013;43(3):361-369. http://dx.doi.org/10.4040/jkan.2013.43.3.361   DOI   ScienceOn
23 Authier N, Gillet JP, Fialip J, Eschalier A, Coudore F. An animal model of nociceptive peripheral neuropathy following repeated cisplatin injections. Experimental Neurology. 2003;182(1):12-20.   DOI   ScienceOn
24 Gill JS, Windebank AJ. Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle. The Journal of Clinical Investigation. 1998;101(12):2842-2850. http://dx.doi.org/10.1172/jci1130   DOI   ScienceOn
25 Yoo YS, Cho OH. Relationship between quality of life and nurse-led bedside symptom evaluations in patients with chemotherapy-induced peripheral neuropathy. Asian Nursing Research. 2014;8(1):36-41. http://dx.doi.org/10.1016/j.anr.2013.11.002   DOI   ScienceOn
26 Powers SK, Smuder AJ, Judge AR. Oxidative stress and disuse muscle atrophy: Cause or consequence? Current Opinion in Clinical Nutrition and Metabolic Care. 2012;15(3):240-245. http://dx.doi.org/10.1097/MCO.0b013e328352b4c2   DOI
27 Castaneda C. Muscle wasting and protein metabolism. Journal of Animal Science. 2002;80(Suppl 2):E98-E105.   DOI
28 Vera G, Castillo M, Cabezos PA, Chiarlone A, Martin MI, Gori A, et al. Enteric neuropathy evoked by repeated cisplatin in the rat. Neurogastroenterology and Motility. 2011;23(4):370-378. http://dx.doi.org/10.1111/j.1365-2982.2011.01674.x   DOI   ScienceOn
29 Kim JI, Choe MA. A comparison between effects of anorexia induced by consecutive low-dose cisplatin and high-dose cisplatin on hindlimb muscles of rats. Journal of Korean Biological Nursing Science. 2012;14 (1):49-56.   DOI   ScienceOn
30 Choe MA, An GJ, Koo BS, Jeon S. Effect of DHEA on recovery of muscle atrophy induced by parkinson's disease. Journal of Korean Academy of Nursing. 2011;41(6):834-842. http://dx.doi.org/10.4040/jkan.2011.41.6.834   DOI   ScienceOn