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Effects of Exercise before Steroid Treatment on Type I and Type II Hindlimb Muscles in a Rat Model  

Choe, Myoung-Ae (College of Nursing, Seoul National University)
An, Gyeong-Ju (Department of Nursing, Catholic University of Daegu)
Publication Information
Journal of Korean Academy of Nursing / v.37, no.1, 2007 , pp. 81-90 More about this Journal
Abstract
Purpose: The purpose of this study was to examine the effects of daily exercise before steroid treatment on mass, the type I and II fiber cross-sectional area, and myofibrillar protein content of hindlimb muscles in a rat model. Method: Adult male Sprague-Dawley rats were randomly assigned to one of three groups: a control group(n=10) that had a normal saline injection for 7days, a steroid group(n=10) that had a steroid injection for 7days, and an exercise-steroid group(n=10) that ran on the treadmill for 7days before a steroid treatment. Body weight and food intake were measured every day. At 15 days all rats were anesthetized and the soleus, plantaris and gastrocnemius muscles were dissected. Result: The exercise-steroid group showed significant increases as compared with the steroid group in body weight, muscle weight of the soleus and gastrocnemius, type II muscle fiber cross-sectional area of plantaris, and myofibrillar protein content of the soleus, plantaris, and gastrocnemius. As compared with the control group, the steroid group showed significant decreases in body weight and diet intake, muscle weight, the type II fiber cross-sectional area and myofibrillar protein content of the soleus, plantaris, and gastrocnemius muscles. Conclusion: Daily exercise before steroid treatment attenuates hindlimb muscle atrophy, with type II muscle changes more apparent than type I muscle changes.
Keywords
Steroid; Exercise; Muscular atrophy; Type I and II fiber cross-sectional area; Myofibrillar protein content;
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1 Choe, M. A., Choi, J. A., & Shin, G. S. (1997). Effect of regular exercise during dexamethasone injection on the body weight, weight of hindlimb muscle and adrenal gland in young rats. J Korean Acad Nurs, 27(3), 510-519   과학기술학회마을
2 Choe, M. A., & Hong, H. S. (2001). Effect of a regular exercise during steroid treatment on the type II muscles of rats. Korean J Sports Med, 19(1), 138-147
3 Hanson, P., Dive, A., Brucher, J. M., Bisteau, M., Dangoisse, M., & Deltombe, T. (1997). Acute corticosteroid myopathy in intensive care patients. Muscle Nerve, 20, 1271-1280
4 Hickson, R. C., Wegrzyn, L. E., Osborne, D. F., & Karl, I. E. (1996). Glutamine interferes with glucocorticoid-induced expression of glutamine synthetase in skeletal muscle. Am J Physiol, 270(5 Pt 1), E912-917
5 Horber, F. F., Hoppeler, H., Scheidegger, J. R., Grunig, B. E., & Frey, F. J. (1987). Impact of physical-training on the ultrastructure of midthigh muscle in normal subjects and in patients treated with glucocorticoids. J Clin Invest, 79, 1181-1190   DOI
6 Lee, M. C., Wee, G. R., & Kim, J. H. (2005). Apoptosis of skeletal muscle on steroid-induced myopathy in rats. J Nutr, 135, 1806S-1808S   PUBMED
7 Munoz, K. A., Aannestad, A., Tischler, M. E., & Henriksen, E. J. (1994). Skeletal muscle protein content and synthesis after voluntary running and subsequent unweighting. Metabolism, 43(8), 994-999   DOI   ScienceOn
8 Seene, T., & Alev, K. (1985). Effect of glucocorticoids on the turnover rate of actin and myosin heavy and light chains on different types of skeletal muscle fibers. J Steroid Biochem, 22, 767-771   DOI   ScienceOn
9 Falduto, M. T., Young, A. P., & Hickson, R. C. (1992). Exercise inhibits glucocorticoid-induced glutamine synthetase expression in red skeletal muscles. Am J Physiol, 262(1 pt 1), C214-220
10 Decramer, M., Laquret, L. M., Fafud, R., & Rogiers, R. (1994). Corticosteroid contribute to muscle weakness in chronic airflow obstruction. Am J Respir Crit Care Med, 150(1), 11-16   DOI   PUBMED   ScienceOn
11 Park, S. J., Lee, M. C., & Kim, S. J. (1999). Effect of physical exercise on experimental steroid-induced myopathy. J Kor Neural Ass, 17, 694-701
12 Caldefie-Chezet, F., Moinard, C., Minet-Quinard, R., Gachon, F., Cynober, L., & Vasson, M. (2001). Dexamethasone treatment induces long-lasting hyperleptinemia and anorexia in old rats. Metab, 50(9), 1054-1058   DOI   ScienceOn
13 Choe, M. A., Shin, G. S., An, G. J., Choi, J. A., & Lee, Y. K. (2002 a). Effect of regular exercise during recovery period following steroid treatment on the atrophied type II muscles induced by steroid in young rats. J Korean Acad Nurs, 32(4), 550-559   과학기술학회마을   DOI
14 Savary, I., Debras, E., Dardevet, D., Sornet, C., Capitan, P., Prugnaud, J., Mirand, P. P., & Grizard, J. (1998). Effect of glucocorticoid excess on skeletal muscle and heart protein synthesis in adult and old rats. Br J Nutr, 79, 297-304   DOI   ScienceOn
15 Czerwinski, S. M., Zak, R., Kurowski, T. T., Falduto, M. T., & Hickson, R. C. (1989). Myosin heavy chain turnover and glucocorticoid deterrence by exercise in muscle. J Appl Physiol, 67(6), 2311-2315   DOI   PUBMED
16 Choe, M. A. (1998). Effect of endurance exercise during dexamethasone treatment on the attenuation of atrophied hindlimb muscle induced by dexamethasone in rats. J Korean Acad Nurs, 28(4), 893-907   DOI
17 Martini, F. H., Ober, W. C., Garrison, C. W., Welch, K., & Hutchings, R. T. (2001). Fundamentals of anatomy & physiology, New Jersey; Prentice Hall
18 Touno, M., Senda, M., Nakago, K., Yokoyama, Y., & Inoue, H. (1996). Muscle fiber changes of the vastus medialis in rheumatoid patients. Acta Med Okayama, 50(3), 157-164   PUBMED
19 Kurowski, T. T., Chatterton, R. T. Jr, & Hickson, R. C. (1984). Countereffects of compensatory overload and glucocorticoids in skeletal muscle: androgen and glucocorticoid cytosol receptor binding. J Steroid Biochem, 21(2), 137-145   DOI   ScienceOn
20 Lapier, T. K. (1997). Glucocorticoid-induced muscle atrophy: The role of exercise in treatment and prevention. J Cardiopulm Rehab, 17(2), 76-84   DOI   ScienceOn
21 Graham, S. C., Roy, R. R., Hauschka, E. O., & Edgerton, V. R. (1989). Effect of periodic weight support on medial gastrocnemius fibers of suspended rats. J Appl Physiol, 67(3), 945-953   DOI   PUBMED
22 Ahtikoski, A. M., Riso, E. M., Koskinen, S. O., Risteli, J., & Takala, T. E. (2004). Regulation of type IV collagen gene expression and degradation in fast and slow muscles during dexamethasone treatment and exercise. Pflugers Arch, 448(1), 123-130   DOI
23 Choe, M. A., Byun, Y. S., Hwang, A. R., Kim, H. S., Hong, H. S., Choi, S. M., Seo, W. S., Lee, K. S., Park, M. J., Shin, G. S., An, G. J., Lee, Y. K., & Im, J. H. (2002 b). Effect of regular exercise during recovery period following steroid treatment on the atrophied hindlimb muscles induced by steroid in rats, J Korean Biol Nurs Sci, 4(1), 85-99
24 Choe, M. A., An, G. J., Lee, Y. K., Im, J. H., S. Choi-Kwon, & Heitkernper, M. (2004). Effect of inactivity and undernutrition after acute ischemic stroke in a rat hindlimb muscle model. Nurs Res, 53(5), 283-292   DOI   ScienceOn
25 Kasper, C. E, McNulty, A. L, Otto, A. J., & Thomas, D. P. (1993). Alterations in skeletal muscle related to impaired physical mobility: an empirical model. Res Nurs Health, 16(4), 265-273   DOI   ScienceOn
26 Ma, K., Mallidis, C., Bhasin, S., Mahabadi, V., Artaza, J., Gonzalez-Cadavid, N., Arias, J., & Salehian, B. (2003). Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Am J Physiolol Endocrinol Metab, 285, E363-E371