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Effect of Vitamin C Supplementation on Blood Sugar and Antioxidative Status in Types II Diabetes Mellitus Patients  

박형숙 (부산대학교 의과대학 간호학과)
이윤미 (인제대학교 의과대학 간호학과)
Publication Information
Journal of Korean Academy of Nursing / v.33, no.2, 2003 , pp. 170-178 More about this Journal
Abstract
Purpose: This study was to determine the effect of oral vitamin C supplements on blood sugar and antioxidative status in Types II diabetes mellitus patients. Method: Data for the study were collected from June 24 to August 31, 2001. Participants(31) took 1g/day vitamin C for 4 weeks, after a 1 - week taking no Vitamin C, followed by Vitamin C 3g/day for 4 weeks. A baseline blood sample was obtained following a 12hour overnight fast and at the end of each 4week Vitamin C administration. Blood samples were taken for plasma vitamin C concentration, fasting blood sugar, HbA1c, superoxide scavenging activity and hydrogen peroxide scavenging activity. The data were analyzed by SPSS for repeated measures ANOVA. Result: Plasma vitamin C concentration was significantly increased over dose(F=3.316, p=.043). Fasting blood sugar and HbA1c was significantly decreased over dose(F=13.192, p=.000; F=11.995, p=.000). Superoxide scavenging activity and hydrogen peroxide scavenging activity was significantly increased over dose(F=486.138, p=.000; F=177.704, p= .000). Conclusion: The results suggest that megadose vitamin C supplementation may have a beneficial effect in diabetes mellitus patients on both glycemic control and antioxidant status. Thus dietary measures to increase plasma vitamin C may be an important health strategy for reducing the compliance of diabetic patients
Keywords
Type II diabetes mellitus; Vitamin C; Blood sugar; Antioxidant status;
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1 Gershoff, S. N. (1993). Vitamin C(Ascorbic Acid) : New Roles, New Requirements?. Nutrition Reviews, 51, 313-326
2 Kim, H. S. (1994). Effect of long-term intake of high dose of vitamin C on free radical scavenger enzymes in human erythrocytes. Seoul National University, Seoul, Korea
3 Lee Y. M. (2002). Effect of vitamin C supplementation on blood sugar and serum lipid in NIDDM patients. Doctoral dissertation, Pusan national university, Busan
4 Breskins, M. W., Trahms, C. M., Worthington-Roberts, B., Label, R. F. & Koslowski, B. (1985). Supplement use : vitamin intakes and biochemical indexes in 40 to 108 month-old children. Journal American Diet Association, 85, 49-56
5 Yokoyama, T., Date, C., Kokubo, Y., Yoshiike, N., Matsumura, Y, & Tanaka, H. (2000). Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community, The Shibata study. Stroke, 31(10), 2287-2294
6 Rose, R. C. & Bode, A. M. (1993). Biology of free radical scavengers: an evaluation of ascorbate. FASEB J, 7, 1135-1142
7 Baynes, J. W. (1991). Role of oxidative stress in development of complications in diabetes. Diabetes, 40, 405-412   DOI   PUBMED   ScienceOn
8 Davie, S. J., Gould, B. J. & Yudkin, J. S. (1992). Effect of vitamin C on glycosylation of proteins. Diabetes, 41, 167-173   DOI   ScienceOn
9 Som, S., Basu, S., Mukherjee, D., Deb, S., Roy, C. P., Mukherjee, S., Chatterjee, S. N. & Chatterjee, I. B. (1981). Ascorbic acid metabolism in diabetes mellitus. Metabolism, 30, 572-577   DOI   ScienceOn
10 Youn, H. S., Choi, M. B., Shin, S. K., Maeng, K. Y. & Rhee, K. H. (1994). Blood and Plasma Vitamin C Concentration and Plasma Protein Carbonyl Formation in Koreans, Kor J Gerntol, 4, 112-120
11 Ha, A. W. & Kim, H. M. (1999). The Study of Lipid-peroxidant, Antioxidant Enzymes, and the Antioxidant Vitamins in NIDDM Patients with Microvascular-diabetic Complcations. Korean Nutr Soc, 32(1), 17-23
12 Kim, N. E. & Kim, W. K. (1999). Effects of antioxidant vitamins supplementation on antioxidative status and plasma lipid profiles in korean NIDDM patients. Korean Nutr Soc., 32(7), 775-780
13 Rivers, J. M. (1987). Safety of High-level Vitamin C Ingestion, In: Third Conference on Vitamin C. Annals of the New York Academy of Sciences, 498, 445-454   DOI   PUBMED   ScienceOn
14 Shin, S, Y, (1996), Effect of vitamin E and vitamin C supplementation on the antioxidative of liver and pancreas of diabetic rats. Master dissertation, Seoul National University, Seoul
15 Garg, M. C., Singh, K. P. & Bansal, D. D. (1997). Effect of vitamin C supplementation on oxidative stress in experimental diabetes. Indian J Exp Biol, 35(3), 264-266
16 Woo, H. O. (1999). Vitamin C concentration in whole blood and plasma among residents living in southern central part of korea. Gyeongsang National University, Chinju, Korea
17 Hoffer, A. (1994). Megavitamin supplement and nutritional strategies for healing and recovery. Journal of Orthomolecular Medicine, 9, 7-37
18 Jialal, I. & Grundy, S. M. (1992). Influence of antioxidant vitamins on LDL oxidation. Ann NY Acad Sci, 669, 237-248   DOI   ScienceOn
19 Gibson, R. S. (1990). Vitamin C. In: Principles of nutritional assessment. Oxford University Press, New York
20 Horning, D. (1999). Benefical Role of Antioxidant Vitamins in the Progression of Diabetic Complications. Diabetes/South East Asia, June, 9, 1-20
21 Sargeant, L. A., Wareham, N. J., Bingham, S., Day, N. E., Luben, R. N., Oakes, S., Welch, A. & Khaw, K.T.(2000). Vitamin C and hyperglycemia in the European Prospective investigation into Cancer -- Norfolk (EPIC - Norfork) study : a population-based study. Diabetes Care, 23, 726-732   DOI   ScienceOn
22 Chen, M. S., Hutchinson, M. L., Pecoraro, R. E., Lee, W. Y. L. & Labb, R. F. (1983). Hyperglycemia-induced intracelluar depletion of ascorbic acid in human mononuclear leukocytes. Diabetes, 32, 1078-1081   DOI   ScienceOn
23 Sinclair, A. J., Taylor, P. B., Lunec, J., Giding, A. J. & Barnett, A. H. (1994). Low plasma ascorbate in patients with type 2 diabetes mellitus consuming adequate dietary vitamin C. Diabet Med, 11(9), 893-898
24 Shim, J. E. (1996), Assement of vitamin C nutritional status and analysis of factors related to serum ascorbic acid levels in diabetes mellitus case and control groups, Master dissertation, Seoul National University, Seoul
25 Collier, A., Wilson, R., Brodley, H., Thomson, J. A. & Small, M. (1990). Free radical activity in type 2 diabetes. Diabet Med, 7, 27-30   DOI   ScienceOn
26 Jacob, R. A. (1990). Assessment of human vitamin C status. J Nutr, 120, 1480-1485
27 Lee, E. O., Im, N.Y. & Park, H,A.(1998). Nursing reaserch and Statical analysis. Seoul ; Sumunsa
28 Caballero, B. (1993). Vitamin C improves the action of insulin. Nutrition Review, 51, 33-340
29 Paolisso, G., D'Amore, A., Baldi, V., Volpe, C., Galzerano, D., Giugliano, D., Sgambato, S., Varricchio, M. & D'Onofrio, F. (1994). Plasma vitamin C affects glucose homeostasis in healthy subjects and in non-insulin-dependent diabetics Americal Journal Physiology, 266, E261-268
30 Eriksson, J. & Kohvakka, A. (1995). Magnesium and ascorbic acid supplementation in diabetes. Annual Nurition and metabolism, 39, 217-223   DOI   ScienceOn