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http://dx.doi.org/10.3795/KSME-B.2014.38.8.715

Application of Cardiac Electromechanical FE Model for Predicting Pumping Efficacy of LVAD According to Heart Failure Severity  

Jung, Dae Hyun (Dept. of Mechatronics Engineering, Kumoh Nat'l Univ.)
Lim, Ki Moo (Dept. of Medical IT Convergence Engineering, Kumoh Nat'l Univ.)
Publication Information
Transactions of the Korean Society of Mechanical Engineers B / v.38, no.8, 2014 , pp. 715-720 More about this Journal
Abstract
In order to maximize the effect of left ventricular assist device (LVAD) on ventricular unloading, the therapy should be begun at appropriate level of heart failure severity. We predicted pumping efficacy of LVAD according to the severity of heart failure theoretically. We used 3 dimensional finite element model of ventricle coupled with 6 Wind-kessel compartmental model of vascular system. Using the computational model, we predicted cardiac responses such as contractile ATP consumption of ventricle, left ventricular pressure, cardiac output, ejection fraction, and stroke work according to the severity of ventricular systolic dysfunction under the treatments of continuous LVAD. Contractile ATP consumption, which indicates the ventricular energetic loading condition decreased maximally at the $5^{th}$ level heart-failure under LVAD therapy. We conclude that optimal timing for LVAD treatment is $5^{th}$ level heart-failure when considering LVAD treatment as "bridge to recovery".
Keywords
Left Ventricular Assist Device; Ventricular Unloading; Finite Element Model; ATP Consumption;
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