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http://dx.doi.org/10.3795/KSME-B.2013.37.7.669

Experimental Study of Machining Process of Polymer Mold for Fabrication of Three-Dimensional Hydrogel Scaffold  

Lee, Pil-Ho (Dept. of Mechanical Engineering, Sungkyunkwan Univ.)
Lee, Sang Won (Dept. of Mechanical Engineering, Sungkyunkwan Univ.)
Kim, Daehoon (Dept. of Mechanical Engineering, Sungkyunkwan Univ.)
Kim, Si Hyeon (Dept. of Chemical Engineering, Hongik Univ.)
Sung, Jong Hwan (Dept. of Chemical Engineering, Hongik Univ.)
Chung, Haseung (Dept. of Mechanical and System Design Engineering, Hongik Univ.)
Publication Information
Transactions of the Korean Society of Mechanical Engineers B / v.37, no.7, 2013 , pp. 669-674 More about this Journal
Abstract
A three-dimensional hydrogel scaffold has been proposed for the effective production of biomimetic intestinal villi to reduce ethical and cost problems caused by animal testing in pharmaceutical development. This study explores an experimental approach to develop a new technique based on laser machining and microdrilling processes to produce a plastic mold for the fabrication of a three-dimensional hydrogel scaffold. For process optimization, both the laser machining and the microdrilling experiments are conducted by varying the experimental conditions, and structural characterization of the mold and intestinal villi were performed using SEM (scanning electron microscope) and OM (optical microscope) images. Polycarbonate (PC) was used as a candidate material. The experimental results show that intestinal villi can be fabricated by both laser and microdrilling machining processes.
Keywords
3-Dimensional Hydrogel Scaffold; Laser Machining; Microdrilling; Biomimetic Engineering;
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Times Cited By KSCI : 2  (Citation Analysis)
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