Browse > Article
http://dx.doi.org/10.3795/KSME-B.2013.37.3.249

Performance Improvement of Polymer Deposition System by Nozzle Guide and Its Application to Washer Scaffold Fabrication  

Sa, Min-Woo (Dept. of Mechanical Engineering, Andong Nat'l Univ.)
Kim, Jong Young (Dept. of Mechanical Engineering, Andong Nat'l Univ.)
Publication Information
Transactions of the Korean Society of Mechanical Engineers B / v.37, no.3, 2013 , pp. 249-257 More about this Journal
Abstract
Rapid prototyping was used to design and develop a three-dimensional (3D) scaffold for tissue engineering application. In this study, the nozzle guide (TB-CP-HN, MUSASHI ENGINEERING, INC., JAPAN) used with the syringe of the polymer deposition system (PDS) was evaluated by measuring the scaffold line width and height. 3D scaffolds were fabricated using a biodegradable polymer called poly-caprolactone (PCL). The PCL polymer can be deposited from the needle of a syringe using a 200-${\mu}m$ precision nozzle, at a pressure of 600 kPa and temperature of $125^{\circ}C$. The advantages and improvements in this nozzle guide were addressed through washer scaffold fabrication. Overall, this research indicated that the fabrication of a complex-shaped scaffold using an enhanced polymer deposition system may have potential for tissue engineering.
Keywords
Rapid Prototyping; Nozzle Guide; Polymer Deposition System; Washer Scaffold;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Hutmacher, D. W., 2000, "Polymeric Scaffolds in Tissue Engineering Bone and Cartilage," Biomaterials, Vol. 21, pp. 2529-2543.   DOI   ScienceOn
2 Mourino, V. and Boccaccini, A. R., 2010, "Bone Tissue Engineering Therapeutics: Controlled Drug Delivery in Three-Dimensional Scaffolds," J. R. Soc., Vol. 7, pp. 209-227.   DOI
3 Freyman, M., Yannas, Y. V. and Gibson, L., 2001, "Cellular Materials as Porous Scaffolds for Tissue Engineering," J. Prog. Mater. Sci., Vol. 46, pp. 273-278.   DOI   ScienceOn
4 Hutmacher, D. W., 2001, "Scaffold Design and Fabrication Technologies for Engineering Tissues: State of the Art and Future Perspectives," J. Biomater. Sci. Polym. Ed, Vol. 12, pp. 107-124.   DOI   ScienceOn
5 Guarino, V., Causa, F. and Ambrosio, L., 2007, "Bioactive Scaffolds for Bone and Ligament Tissue," Exp. Rev. Med. Devices, Vol. 4, pp. 405-418.   DOI   ScienceOn
6 Moroni, L., De Wijn, J. R. and Van Blitterswik, C. A., 2008, "The Integrating Novel Technologies to Fabricate Smart Scaffolds," J. Biomater. Sci. Polym. Ed., Vol. 19, pp. 543-572.   DOI   ScienceOn
7 Chen, Q. Z., Bretcanu, O. and Boccaccini, A. R., 2008, "Inorganic and Composite Bioactive Scaffolds for Bone Tissue Engineering." In Biomaterials Fabrication and Processing Handbook (Eds P. K. Chu & X. Liu). Boca Raton, FL: CRC Press.
8 Ahn, S. H., Koh, Y. H. and Kim, G. H., 2010, "A Three-Dimensional Hierarchical Collagen Scaffold Fabricated by a Combined Solid Freeform Fabrication (SFF) and Electrospinning Process to Enhance Mesenchymal Stem Cell (MSC) Proliferation," J. Micromech. Microeng., Vol. 20, No. 6, 065015(7pp)
9 Kim, J. Y., Park, E. K., Kim, S. Y. and Cho, D. W., 2008, "Development of Multi-Head Deposition System and Fabrication of 3D Scaffolds for Tissue Engineering," KSPE 08S052, pp. 105-106.
10 Iwan, Z., Hutmacher, D. W., Kim, C. T. and Swee, H. T., 2002, "Fused Deposition Molding of Novel Scaffold Architectures for Tissue Engineering Applications," Biomaterials, Vol. 23, pp. 1169-1185.   DOI   ScienceOn
11 Kim, J. Y., Park, E. K., Kim, S. Y., Shin, J. W. and Cho, D. W., 2008, "Fabrication of a SFF-Based Three-Dimensional Scaffold Using a Precision Deposition System in Tissue Engineering," J. Micromech. Microeng., Vol. 18, No. 5, 055027(7pp)
12 Yeo, M. G. and Kim, G. H., 2011, "Preparation and Characterization of 3D Composite Scaffolds Based on Rapid-Prototyped PCL/$\beta$-TCP Struts and Electrospun PCL Coated with Collagen and HA for Bone Regeneration," Chem. Mater., Vol. 24, No. 4, pp. 903-913.
13 Kim, J. Y., Yoon, J. J., Park, E. K., Kim, S. Y. and Cho, D. W., 2009, "Fabrication of 3D PCL/PLGA/TCP Bioscaffold Using Multi-Head Deposition System and Design of Experiment," KSPE, Vol. 26, pp. 146-154.
14 Shim, J. H., Lee, J. S. and Kim, J. Y., 2012, "Fabrication of Solid Freeform Fabrication Based 3D Scaffold and Its In-Vitro Characteristic Evaluation for Bone Tissue Engineering," Tissue Eng. Regen. Med., Vol. 9, No. Suppl.1, pp. 16-23.
15 Vozzi, G., Previti, A., De Rossi, D., M. S. and Ahluwalia, A., 2002, "Microsyringe based Deposition of Two Dimensional and Three Dimensional Polymer Scaffolds with a Well Defined Geometry for Application to Tissue Engineering," Tissue Eng., Vol. 8, No. 6, pp. 1089-1098.   DOI   ScienceOn
16 Lee, S. G., 2008, "Percutaneous Pedicle Screw Fixation in the Lumbar Spine," Hanyang Med. Rev., Vol. 28, No. 1, pp. 59-64.
17 Shin, B. G., Lee, J. C., Kim, Y. I., and Lee, J, S., 2009, "More Than 5 Year Follow-Up of Thoracolumbar Fractures Treated By Pedicle Screw Fixation," J. Korean Soc. Spine Surg., Vol. 16, No. 4, pp. 251-258.   DOI   ScienceOn