Browse > Article
http://dx.doi.org/10.3795/KSME-B.2011.35.5.547

Painless Microjet Injector Using Laser Pulse Energy  

Yoh, Jai-Ick (School of Mechanical and Aerospace Engineering, Seoul Nat'l Univ.)
Han, Tae-Hee (School of Mechanical and Aerospace Engineering, Seoul Nat'l Univ.)
Hah, Jung-Moo (School of Mechanical and Aerospace Engineering, Seoul Nat'l Univ.)
Publication Information
Transactions of the Korean Society of Mechanical Engineers B / v.35, no.5, 2011 , pp. 547-550 More about this Journal
Abstract
We have developed a laser-based needle-free liquid drug-injection device. A laser beam is focused inside the liquid contained in the rubber chamber of a micro-scale. The focused laser beam causes explosive bubble growth, and the sudden volume increase in a sealed chamber drives a microjet of liquid drug through the micronozzle. The exit diameter of a nozzle is less than 100 ${\mu}m$, and we verify that the injected microjet is fast enough to penetrate soft human tissue. In the experiment, the microjet penetrated a 5% gelatin-water solution that replicates the human thrombus and pork-fat tissue.
Keywords
Laser Pulse; Microjet; Bubble Collapse; Drug Delivery System; Shock Wave;
Citations & Related Records

Times Cited By SCOPUS : 0
연도 인용수 순위
  • Reference
1 Nir, Y., Paz, A., Sabo, E. and Potasman, I., 2003, “Fear of Injections in Young Adults,” Am. J. Trop. Med. Hyg., Vol. 68, pp. 341-344.
2 Kermode, M., 2004, “Unsafe Injections in Low-Income Country Health Settings: Need for Injection Safety Promotion to Prevent the Spread of Blood-Borne Viruses,” HealthPromot. Int., Vol. 19, pp. 95-103.
3 Mitragotri, S., 2004, “Current Status and Future Potential of Transdermal Drug Delivery,” Nat .Rev. Drug Discov. Vol. 3, pp. 125-124.   DOI   ScienceOn
4 Hoffman, P. N., Abuknesha, R.A., Andrews, N. J., Samuel, D. and Lloyd, J. S., 2001, “A Model to Assess the Infection Potential of Jet Injectors Used in Mass Immunisation,” Vaccine, Vol. 19, pp. 4020-4027.   DOI   ScienceOn
5 Theintz, G. E. and Sizonenko, P. C., 2009, “Risks of Jet Injection of Insulin in Children,” Eur.J.Pediatr., Vol. 150, pp. 554-556.
6 Stachowiak, J. C., Li, T. H., Arora, A., Mitragotri, S. and Fletcher, D. A., 2009, “Dynamic Control of Needle-Free Jet Injection,” J. of Cont. Release, Vol. 135, pp. 104-112.   DOI   ScienceOn
7 Menezes, V., Kumar, S. and Takayama, K., 2009, “Shock Wave Driven Liquid Microjets for Drug Delivery,” J. of Appl. Phys., Vol. 106, 086102.   DOI   ScienceOn
8 Siegman, A. E., 1986, “Lasers,” CA: University Science Books, pp. 74-76.