Browse > Article
http://dx.doi.org/10.3795/KSME-B.2011.35.11.1237

Fabrication of Calcium Phosphate Scaffolds Using Projection-based Microstereolithography and Their Effects on Osteogenesis  

Seol, Young-Joon (Dept. of Mechanical Engineering, Center for Rapid Prototyping Based 3D Tissue/Organ Printing, POSTECH)
Park, Ju-Young (Dept. of Mechanical Engineering, Center for Rapid Prototyping Based 3D Tissue/Organ Printing, POSTECH)
Cho, Dong-Woo (Dept. of Mechanical Engineering, Center for Rapid Prototyping Based 3D Tissue/Organ Printing, POSTECH)
Publication Information
Transactions of the Korean Society of Mechanical Engineers B / v.35, no.11, 2011 , pp. 1237-1242 More about this Journal
Abstract
Calcium phosphates are very interesting materials for use as scaffolds for bone tissue engineering. These materials include hydroxyapatite (HA) and tricalcium phosphate (TCP), which are inorganic components of human bone tissue and are both biocompatible and osteoconductive. Although these materials have excellent properties for use as bone scaffolds, many researchers have used these materials as additives to synthetic polymer scaffolds for bone tissue regeneration, because they are difficult to manufacture three-dimensional (3D) scaffolds. In this study, we fabricated 3D calcium phosphate scaffolds with the desired inner and outer architectures using solid freeform fabrication technology. To fabricate the scaffold, the sintering behavior was evaluated for various sintering temperatures and slurry concentrations. After the fabrication of the calcium phosphate scaffolds, in-vitro cell proliferation and osteogenic differentiation tests were carried out.
Keywords
Bone Tissue Regeneration; Calcium Phosphate; Scaffold; Solid Freeform Fabrication;
Citations & Related Records

Times Cited By SCOPUS : 1
연도 인용수 순위
  • Reference
1 Jung, G.-Y., Park, Y.-J. and J Han,.-S., 2010, "Effects of HA Released Calcium Ion on Osteoblast Differentiation," J Mater Sci: Mater Med, Vol. 21, pp. 1649-1654.   DOI   ScienceOn
2 Zayzafoon, M., 2006, "Calcium/Calmodulin Signaling Controls Osteoblast Growth and Differentiation," Journal of Cellular Biochemistry, Vol. 97, pp. 56-70.   DOI   ScienceOn
3 Kandel, R.A., Grynpas, M., Pilliar, R., Lee, J., Wang, J., Waldman, S., Zalzal, P., Hurtig, M. and CIHRBioengineering of Skeletal Tissue Team, and Han, J.- S., 2006, "Repair of Osteochondral Defects with Biphasic Cartilage-Calcium Polyphosphate Constructs in a Sheep Model," Biomaterials, Vol. 27, pp. 4120-4131.   DOI   ScienceOn
4 Barralet, J.E., Grover, L., Gaunt, T., Wright, A.J. and Gibson, I.R., 2002, "Preparation of Macroporous Calcium Phosphate Cement Tissue Engineering Scaffold," Biomaterials, Vol. 23, pp. 3063-3072.   DOI   ScienceOn
5 Deville, S., Saiz, E. and Tomsia, A. P., 2006, "Freeze Casting of Hydroxyapatite Scaffolds for Bone Tissue Engineering," Biomaterials, Vol. 27, pp. 5480-5489.   DOI   ScienceOn
6 Kim, S.-S., Park, M. S., Jeon, O., Choi, C. Y. and Kim, B.-S., 2006, "Poly(lactide-co-glycolide)/ Hydroxyapatite Composite Scaffolds for Bone Tissue Engineering," Biomaterials, Vol. 27, pp. 1399-1409.   DOI   ScienceOn
7 Rezwan, K., Chen, Q.Z., Blaker, J.J. and Boccaccini, A. R., 2006, "Biodegradable and Bioactive Porous Polymer/Inorganic Composite Scaffolds for Bone Tissue Engineering," Biomaterials, Vol. 27, pp. 3413-3431.   DOI   ScienceOn
8 Zhang, Y. and Zhang, M., 2000, "Synthesis and Characterization of Macroporous Chitosan/Calcium Phosphate Composite Scaffolds for Tissue Engineering," Journal of Biomedical Materials Research, Vol. 55, pp. 304-312.
9 Lan, P. X., J Lee,. W., Seol, Y.-J. and Cho, D.-W., 2009, "Development of 3D PPF/DEF Scaffolds Using Micro-Stereolithography and Surface Modification," J Mater Sci: Mater Med, Vol. 20, pp. 271-279.
10 Hutmacher, D. W., 2000, "Scaffolds in Tissue Engineering Bone and Cartilage," Biomaterials, Vol. 21, pp. 2529-2543.   DOI   ScienceOn
11 Ifkovits, J. L. and Burdick, J. A., 2007, "Review: Photopolymerizable Biomaterials for Tissue Engineering Applications," Tissue Engineering, Vol. 13, No. 10, pp. 2369-2385.   DOI   ScienceOn
12 Schieker, M., Seitz, H., Drosse, I., Seitz, S. and Mutschler, W., 2006, "Biomaterials as Scaffold for Bone Tissue Engineering," European Journal of Trauma, Vol. 32, No. 2, pp. 114-124.   DOI
13 Lu, J., Descamps, M., Dejou, J., Koubi, G., Hardouin, P., Lemaitre, J. and Proust, J.-P., 2002, "The Biodegradation Mechanism of Calcium Phosphate Biomaterials in Bone," J Biomed Mater Res, Vol. 63, No. 4, pp. 408-412.   DOI   ScienceOn