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http://dx.doi.org/10.3795/KSME-B.2007.31.4.320

Development and Validation of Numerical Program for Predicting Electrokinetic and Dielectrophoretic Phenomena in a Microchannel  

Kwon, Jae-Sung (한양대학교 기계기술연구소)
Maeng, Joo-Sung (한양대학교 기계공학부)
Song, Simon (한양대학교 기계공학부)
Publication Information
Transactions of the Korean Society of Mechanical Engineers B / v.31, no.4, 2007 , pp. 320-329 More about this Journal
Abstract
Electrokinesis and dielectrophoresis are important transport phenomena produced by external electric field applied to a microchannel containing a conductive fluid. We developed a CFD code to predict electrokinetic and dielectrophoretic flows in a microchannel with a uniform circular post array. Using the code, we calculated particle velocities driven by electrokinesis and dielectrophoresis, and conducted Monte Carlo simulations to visualize the particle motions. The code was validated by comparing the results with those from previous studies in literature. At a low electric field, electrokinesis and diffusion is the dominant transport mechanism. At a moderate electric field, dielectrophoresis is balanced with electrokinesis and diffusion, resulting in flowing filaments of particles in the microchannels. However, dielectrophoresis overwhelms the flow at a high electric field and traps particles locally. These results provide useful insight for optimizing design parameters of a microfluidic chip for biochemical analysis, especially for development of on-chip sample pretreatment techniques using electrokinetic and dielectrophoretic effects.
Keywords
Microfluidic Chip; Sample Pretreatment; Electrokinesis; Dielectrophoresis; Monte-Carlo Simulation;
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  • Reference
1 Sanders, G. H. W. and Manz, A., 2000, 'Chip-based Microsystems for Genomic and Proteomic Analysis,' Trends in Analytical Chemistry, Vol. 19, No. 6, pp. 364-378   DOI   ScienceOn
2 Cummings, E. B., Griffiths, S. K., Nilson, R. H. and Paul, P. H., 2000, Condition for Similitude between the Fluid Velocity and Electric Field in Electroosmotic Flow,' Analytical Chemistry, Vol. 72, pp. 2526-2532   DOI   ScienceOn
3 Press, W. H., Teukolsky, S. A., Vetterling, W. T. and Flannery, B. P., 1992, Numerical Recipes in C, Cambridge University Press, New York
4 Ermakov, S. V., Jacobson, S. C. and Ramsey, J. M., 1998, 'Computer Simulations of Electrokinetic Transport in Microfabricated Channel Structures,'Analytical Chemistry, Vol. 70, No. 21, pp. 4494-4504   DOI   ScienceOn
5 Morrison, F. A., 1970, 'Electrophoresis of a Particle of Arbitrary Shape,' Journal of Colloid and Interface Science, Vol. 34, No. 2, pp. 210-214   DOI   ScienceOn
6 Atramentov, A. and LaValle, S. M., 2002, 'Efficient Nearest Neighbor Searching for Motion Planning,' IEEE International Conference on Robotics and Automation, Vol. 1, pp. 632-637   DOI
7 Prevost, M., Edwards, M. G. and Blunt, M. J., 2001, 'Streamline Tracing on Curvilinear Structured and Unstructured Grids,' Proc. Society of Petroleum Engineers
8 Cummings, E. B. and Singh, A. K., 2000, 'Dielectrophoretic Trapping without Embedded Electrodes,' Proc. of the SPIE Symposium on. Micromachining and Microfabrication, Vol. 4177, No. 29, pp. 164-173   DOI
9 Cummings, E. B. and Singh, A. K., 2003, 'Dielectrophoresis in Microchips Containing Arrays of Insulating Posts: Theoretical and Experimental Results,' Analytical Chemistry, Vol. 75, pp. 4724-4731   DOI   ScienceOn
10 Ikeda, I., Tsukahara, S. and Watarai, H., 2003, 'Effects of Viability and Lectin Protein Binding on Dielectrophoretic Behavior of Single Yeast Cells,' Analytical Sciences, Vol. 19, pp. 27-31   DOI   ScienceOn
11 Ermolina, I. and Morgan, H., 2005, 'The Electrokinetic Properties of Latex Particles: Comparison of Electrophoresis and Dielectrophoresis,' Journal of Colloid and Interface Science, Vol. 285, pp. 419-428   DOI   ScienceOn
12 Lapizco-Encinas, B. H., Simmons, B. A., Cummings, E. B. and Fintschenko, Y., 2004, 'Dielectrophoretic Concentration and Separation of Live and Dead Bacteria in an Array of Insulators,' Analytical Chemistry, Vol. 76, pp. 1571-1579   DOI   ScienceOn
13 Thomson, J. F., Thames, F. C. and Mastin, C. W., 1974, 'Automatic Numerical Generation of Bodyfitted Curvilinear Coordinate System for FieldContaining Any Number of Arbitrary Twodimensional Bodies,' Journal of Computational Physics, Vol. 59, pp. 151-163
14 Choi, I. K. and Maeng, J. S., 1999, 'Automated Body-Fitted Grid Generation Method with Application to Natural Convection Problem,' Trans. of the KSME(B), Vol. 23, No. 6, pp. 703-712
15 Pohl, H. A., 1978, Dielectrophoresis: The Behavior of Neutral Matter in Nonuniform Electric Fields, Cambridge University Press, London
16 Jones, T. B., 1995, Electromechanics of Particles, Cambridge University Press, London
17 Hughes, M. P., Pethig, R. and Wang, X.-B., 1996, 'Dielectrophoretic Forces on Particles in Travelling Electric Fields,' Journal of Physics D: Applied Physics, Vol. 29, pp. 474-482   DOI   ScienceOn
18 Green, N. G. and Morgan, H., 1997, 'Dielectrophoretic Investigations of Sub-micrometre Latex Spheres,' Journal of Physics D: Applied Physics, Vol. 30, pp. 2626-2633   DOI   ScienceOn
19 Wakizaka, Y., Hakoda, M. and Shiragami, N., 2004, 'Effect of Electrode Geometry on Dielectrophoretic Separation of Cells,' Biochemical Engineering Journal, Vol. 20, pp. 13-19   DOI   ScienceOn
20 Manz, A., Harrison, J., Verpoorte, E. M. J., Fettinger, J. C., Paulus, A., Ludi, H. and Widmer, H. M., 1992, 'Planar Chips Technology for Miniaturization andIntegration of Separation Techniques into Monitoring Systems,' Journal of Chromatography, Vol. 593, pp.253-258   DOI   ScienceOn
21 Li, D., 2004, Electrokinetics in Microfluidics, Elservier Academic Press, London
22 Probstein, R. F., 1994, Physicochemical Hydrodynamics: An Introduction, John Wiley & Cons. Inc, New York
23 Aguilella, V., Belaya, M. and Levadny, V., 1997, 'A Perturbed Electric Double Layer Near a Soft Polar Interface,' Journal of Colloid and Interface Science, Vol. 186, pp. 212-214   DOI   ScienceOn
24 Gu, Y. and Li, D., 2000, 'The Zeta Potential of Glass Surface in Contact with Aqueous Solutions,' Journal of Colloid and Interface Science, Vol. 226, pp. 328-339   DOI   ScienceOn
25 Green, N. G., Ramos, A. and Morgan, H., 2000, 'Ac Electrokinetics: A Survey of Sub-micrometre Particle Dynamics,' Journal of Physics D: Applied Physics, Vol. 33, pp. 632-641   DOI   ScienceOn
26 Lichtenberg, J., deRooij, N. F. and Verpoorte, E., 2002, 'Sample Pretreatment on Microfabricated Devices,' Talanta, Vol. 56, pp. 233-266   DOI   ScienceOn
27 Stephen C. Jacobson, Roland Hergenroder, Lance B. Koutny, J. Michael Ramsey, 'High-Speed Separations on a Microchip,' Anal. Chem., 66, 1114-1118, 1994   DOI   ScienceOn