Browse > Article
http://dx.doi.org/10.3795/KSME-A.2006.30.1.001

An Electrical Signal Detection System Using Nanoparticle for a Microbiochip  

Raa Kwang Youel (한양대학교 대학원)
Park Jae Jun (한양대학교 대학원)
Lee Seoung Hwan (한양대학교 기계공학과)
Ahn Yoo Min (한양대학교 기계공학과)
Cho Nahm Gyoo (한양대학교 기계공학과)
Hwang Seung Yong (한양대학교 분자생명과학부)
Publication Information
Transactions of the Korean Society of Mechanical Engineers A / v.30, no.1, 2006 , pp. 1-7 More about this Journal
Abstract
A system for the electrical bio signal detection for a microchip is proposed. Gold nanoparticles were selected for the system for their bio-compatibility and potential for higher sensitivity with large surface areas. For the estimation of the conductivity of gold nanoparticles, microchips with interdigitated microelectrodes of 3,5,7 and $9\;{\mu}m$ spacing were fabricated. In addition, a simulation program was developed to estimate the electrical resistance of the fabricated microchip. The results of conduction simulation for the nanoparticles show good agreements with experimental data, which validate the proposed system.
Keywords
Microbiochip; Electrical Detection; Nanoparticle; Conductivity; Microelectrode; MEMS;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Harris, T., 2000, 'Genetics, Genomics and Drug Discovery,' Medicinal Research Reviews, Vol. 20, pp. 203-211   DOI   ScienceOn
2 Vo-Dinh, T., Cullum, B., 2000, 'Biosensors and Biochips : Advance in Biological and Medical Diagnostics,' Fresenius Journal of Analytical Chemistry, Vol. 366, pp. 540-551   DOI
3 Albers, J., Grunwald, T., Nebling, E., Piechotta, G., Hintsche, R., 2003, 'Electrical Biochip Technology - a Tool for Microarrays and Continuos Monitoring,' Analytical and Bioanalyical Chemistry, Vol. 377, No. 3, pp. 521-527   DOI
4 Burnmeister, J., Bazilyanska, V., Grothe, K., Koehelr, B., Dorn, I., Warner, B.D., Diesel, E., 2004, 'Single Nucleotide Polymorphism Analysis by Chip-Based Hybridization and Direct Current Electrical Detection of Gold-Labeled DNA,' Analytical Bioanalyticl Chemisty, Vol. 379, No. 3, pp. 391-398   DOI
5 Park.J.G, 2000, 'Biochip Technology and Application,' Proceeding of KIEE, Vol. 49, No. 2, pp. 17-23
6 Nicolini, C., 1995, 'From Neural Chip and Engineering Biomolecules to Bioelectronic Devices : and Overview,' Biosensors & Bioelectronics, Vol. 1, No. 1/2, pp. 105-127   DOI   ScienceOn
7 Park, J.J., 2005, 'A Study on an Electrical Biosignal Detection System for the Microbiochip' KSPE, Vol. 22. No. 4   과학기술학회마을
8 Hyatt, M.A., 1989, 'Colloidal Gold : Principles, Methods and Applications,' Academic Press, pp. 1-32
9 Moller, R., Csaki, A., Kohler, J. M., Fritzsche, W., 2001, 'Electrical Classification of the Concentration of Bioconjugated Metal Colloids After Surface Adsorption and Silver Enhancement,' Langmuir, Vol. 14, pp. 5426-5430   DOI   ScienceOn
10 Haguet, V., Martin, D., .Marcon, L., Heim, T., Stievenard, D., Oliver, C., El-Mahdi, O., Melnyk, O., 2004, 'Combined Nanogap Nanoparticles Nanosensor for Electrical Detection of Biomolecular Interactions Between Polypeptides' Applied Physics Letters, Vol. 84, No. 7, pp. 12113-1215   DOI   ScienceOn
11 Kerman, K., Kobayashi. M., Tamiya, E., 2004, 'Recent Trends in Electrochemical DNA Biosensor Technology,' Measurement science & technology,' Vol.15, pp. R1-R11   DOI   ScienceOn
12 Park.S.J, Taton, T.A., Mirkin, C. A., 2002, 'Array-Based Electrical Detection with Nanoparticle probes,' SIENCE, Vol. 295, No. 5559, pp. 1506-1508   DOI   ScienceOn
13 Piunno, P., Krull, U., Hudson, R., Dahma, M., Cohen, H., 1995, 'Fiber-Optic DNA Sensor for Fluorometric Nucleic Acid Determination' Analytical Chemistry, Vol. 67, pp. 2635-2643   DOI   ScienceOn
14 Wang, J., 2003, 'Nanoparticle-Based Electrochemical DNA Detection,' Analytica Chimica Acta, Vol. 500. pp. 247-257   DOI   ScienceOn
15 Schwarz, M. A., Hauser, P. C., 2001, 'Recent Development in Detection Methods for Microfabricated Analytical Devices,' Lab on a chip, Vol. 1,pp. 1-6   DOI   ScienceOn
16 Yoshio O., Yuka M., Kuniharu I., Masayuki M., Akia M., and Keisuke M., 1992, 'Hybridization of Nuclec Acids Immobilized on a Quartz Crystal Microbalance,' Journal of the American Chemical Society, Vol. 114, pp. 8299-8300   DOI