Browse > Article

The Prevalence of Respiratory Viral Infection in Exacerbation of Asthma in Hospitalized Children  

Roh, Eui-Jung (Departments of Pediatrics, College of Medicine, Dankook University)
Jin, Yong-Man (Departments of Pediatrics, College of Medicine, Dankook University)
Rheem, In-Soo (Departments of Laboratory Medicine, College of Medicine, Dankook University)
Kim, Jae-Kyung (Departments of Laboratory Medicine, College of Medicine, Dankook University)
Chung, Eun-Hee (Departments of Pediatrics, College of Medicine, Dankook University)
Publication Information
Journal of asthma, allergy and clinical immunology / v.27, no.4, 2007 , pp. 241-247 More about this Journal
Abstract
Background: Respiratory viral infections are common exacerbating factors for asthma in children. Recently the detection of respiratory viruses can be improved by using molecular biology techniques, which providing a method capable of detecting an increasing number of viruses. Objectives : The aim of this study was to evaluate the causative viral infections and their seasonal trends in children who were admitted with the exacerbation of their asthma by multiplex polymerase chain reaction (PCR) assay. Methods: Nasopharyngeal aspirates were obtained from hospitalized asthmatic children at Dankook University Hospital from November 2005 through Febraury 2007. Multiplex PCR assay was used for the detection of respiratory viruses. The demographic and clinical characteristics were reviewed retrospectively from the patients’ medical records. Results: During the study period, 58 were hospitalized due to acute asthma exacerbations. Of these, infectious agents were detected in 38 (65.5%) of the patients. Resipiratoy syncytial virus was detected in 18 (31%), influenza virus in 10 (17.2%), rhinovirus in 7 (12.1%), coronavirus in 5 (8.6%), adenovirus in 4 (6.9%), parainfluenza virus in 5 (8.6%) and human metapneumovirus in 2 (3.4%). Conclusion: It is suggested that the causative virus in hospitalized children with asthma exacerbations follow may the epidemic of respiratory virus in hospitalized children with respiratory infection.
Keywords
Asthma; Virus; Polymerase chain reaction; Children
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Weinberg GA, Erdman DD, Edwards KM, Hall CB, Walker FJ, Griffin MR, et al. Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children. J Infect Dis 2004; 189:706-10   DOI   ScienceOn
2 Freymuth F, Vabret A, Cuvillon-Nimal D, Simon S, Dina J, Legrand L, et al. Comparison of multiplex PCR assay and conventional techniques for the diagnositic of respiratory virus infections in children admitted to hospital with an acute respiratory illness. J Med Virol 2006;78:1498-504   DOI   ScienceOn
3 Gilbert LL, Dakhama A, Bone BM, Thomas EE, Hegele RG. Diagnosis of viral respiratory tract infections in children by using a reverse transcription-PCR panel. J Clin Microbiol 1996;34:140-3
4 Freymuth F, Vabret A, Galateau-Salle F, Ferey J, Eugene G, Petitjean J, et al. Detection of respiratory syncytial virus, parainfluenzavirus 3, adenovirus and rhinovirus sequences in respiratory tract of infants by polymerase chain reaction and hybridization. Clin Ciagn Virol 1997;8:31-40   DOI   ScienceOn
5 Gern JE. Rhinovirus respiratory infections and asthma. Am J Med 2002;112:19-27
6 Lemanske RF. Viral infections and asthma inception. J Allergy Clin Immunol 2004;114:1023-6   DOI   ScienceOn
7 Gem JE. Viral and bacterial infections in the development and progression and asthma. J Allergy Clin Immunol 2000;105: 497-502   DOI   ScienceOn
8 Drews AL, Atmar RL, Glezen WP, Baxter BD, Piedra PA, Greenberg SB, et al. Dual respiratory virus infections. Clin Infect Dis 1997;25:1421-9   DOI   ScienceOn
9 Pattemore PK, Johnston SL, Bardin PG. Viruses as precipitants of asthma symptoms. I. Epidemiology. Clin Exp Allergy 1992; 22:325-6   DOI   ScienceOn
10 Johnston SL, Sanderson G, Pattemore PK, Smith S, Bardin PG, Bruce CB, et al. Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with or without respiratory symptoms. J Clin Microbiol 1993;31:111-7
11 Heymann PW, Carper HT, Murphy DD, Platts-Mills TAE, Patrie J, McLaughlin AP, et al. Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. J Allergy Clin Immunol 2004;114:239-47   DOI   ScienceOn
12 Green RM, Custovic A, Sanderson G, Hunter J, Johnston SL, Woodcock A. Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ 2002; 324:763-6   DOI   ScienceOn
13 Montalbano MM, Lemanske Jr RF. Infections and asthma in children. Curr Opin Pediatr 2002;14:334-7   DOI   ScienceOn
14 Khetsuriani N, Kazerouni NN, Erdman DD, Lu X, Redd SC, Anderson LJ, et al. Prevalence of viral respiratory tract infection in children with asthma. J Allergy Clin Immunol 2007;119: 314-21   DOI   ScienceOn
15 Petitjean J, Vabret A, Gallateau-Salle F, Ferey J, Eugene G, Guillois B, et al. Detection of respiratory syncytial virus, parain fluenzavirus 3, adenovirus and rhinovirus sequences in respiratory tract of infants by PCR and hybridization. Clin Diagn Virol 1997;8:31-40   DOI   ScienceOn
16 Johnston SL, Pattemore PK, Sanderson G, Smith S, Campbell MJ, Josephs LK, et al. The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med 1996;154:654-60   DOI
17 Kuypers J, Wright N, Ferreberg J, Huang ML, Cent A, Corey L, et al. Comparison of real-time PCR assays with fluorescent-antibody assays for diagnosis of respiratory virus infections in children. J Clin Microbiol 2006;44:2382-8   DOI   ScienceOn
18 Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ 1993;307:982-6   DOI   ScienceOn
19 Templeton KE, Scheltinga SA, Beersma MF, Kroes AC, Claas EC. Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza A and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4. J Clin Microbiol 2004;42:1564-9   DOI   ScienceOn
20 GINA workshop report updated 2005. Global strategy for asthma management and prevention 2006, Washington, DC, February 2006, U.S. Department of Health and Human Services. NIH Publication No 02-3659 Issued January, 1995: Updated 2005
21 Busse WW. The contribution of viral respiratory infections to the pathogenesis of airway hyperreactivity. Chest 1988;93:1976-82
22 Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerations of asthma 9-11 year old children. BMJ 1995;310: 1225-38   DOI   ScienceOn
23 Freymuth F, Vabret A, Brouard J, Toutain F, Verdon R, Petitjean J, et al. Detection of viral, chylamydia pneumonia and mycoplasma pneumonia. infections in exacerbations of asthma in children. J Clin Virol 1999;13:131-9   DOI   ScienceOn
24 Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs S, et al. Role of virus infections in children with recurrent wheeze or cough. Thorax 1993;48:1055-60
25 Chung EH, Roh EJ, Chang YP, Park WS, Kim JK, Rheem IS. Comparison of multiplex PCR with viral cultures and immunofluorescent antigen detection for respiratory virus in hospitalized children. Abstract on Pediatr Allergy Respir Dis (Korea) 2007; 17:32
26 Oh JW. Respiratory viral infections and early asthma in childhood. Allergo Internat 2006;55:369-72   DOI
27 Tan WC. Viruses in asthma exacerbations. Curr Opin Pulm Med 2004;11:21-6
28 Tan WC, Xiang X. Qiu D, Ng TP, Lam SF, Hegele RG. Epidemiology of respiratory viruses in patients hospitalized with near-fetal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease. Am J Med 2003;115:272-7   DOI   ScienceOn
29 Thumerelle C, Deschildre A, Bouquillon C, Santos C, Sardet A, Scalbert M, et al. Role of viruses and atypical bacteria in exacerbations of asthma in hospitalized children: A prospective study in the Nord-Pas de Calais Region (France). Pediatr Pulmonol 2003; 35:75-82   DOI   ScienceOn