Browse > Article
http://dx.doi.org/10.22643/JRMP.2002.8.71

Indigenous Radiosynthesis of [131I]Iodobenzylguanidine ([131I]mIBG) for Neuroblastoma Imaging  

Nadeem Ahmed Lodhi (Isotope Production Division, Pakistan Institute of Nuclear Science & Technology (PINSTECH))
Muhammad Irfan (Isotope Production Division, Pakistan Institute of Nuclear Science & Technology (PINSTECH))
Muhammad Nasir Saddique (Isotope Production Division, Pakistan Institute of Nuclear Science & Technology (PINSTECH))
Kahkshan Bashir Mir (Nuclear Medicine, Oncology & Radiotherapy Institute (NORI))
Naseer Ahmed (Nuclear Medicine, Oncology & Radiotherapy Institute (NORI))
Shazia Fatima (Nuclear Medicine, Oncology & Radiotherapy Institute (NORI))
Mumtaz Khan (Health Physics Division, Pakistan Institute of Nuclear Science & Technology (PINSTECH))
Muhammad Wasim (Isotope Production Division, Pakistan Institute of Nuclear Science & Technology (PINSTECH))
Samina Roohi (Isotope Production Division, Pakistan Institute of Nuclear Science & Technology (PINSTECH))
Publication Information
Journal of Radiopharmaceuticals and Molecular Probes / v.8, no.2, 2022 , pp. 71-76 More about this Journal
Abstract
Indigenous diagnostic dose of 131I-labeled meta-iodobenzylguanidine ([131I]mIBG) was prepared via Cu+ catalyzed isotope exchange reaction generated in situ by sodium metabisulfite for imaging of neuroblastoma tumor. [131I]mIBG was produced in overall 85-90% radiochemical yield. The average amount of radioactivity of [131I]mIBG was 2164 MBq (1998-2331MBq) with an average specific activity > 1000 MBq/mg at the end of synthesis. The radiochemical purity was ≥ 99.9% after purification through Dowex-1 × 8 ion exchange resin (100-150 mesh) at the date of preparation. The stability of [131I]mIBG at concentration 480-555 MBq/mL was > 97% at 4 ℃ after 4 days. The room temperature (25 ℃) stability of [131I]mIBG was > 98% after 24 h. Biodistribution of [131I]mIBG in patient showed uptake in salivary glands, liver, spleen and excreted though urinary bladder. Neuroendocrine medicated uptake into tumor lesion and metastatic sites were noted which strongly correlate with the morphological abnormalities of patient.
Keywords
meta-iodobenzylguanidine; Iodine-131; Radioiodination; Copper catalyzed reaction;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Streby KA, Shah N, Ranalli MA, Kunkler A, Cripe TP. Nothing but NET: A review of norepinephrine transporter expression and efficacy of 131I-mIBG therapy. Pediatric Blood & Cancer 2015:62(1):5-11.   DOI
2 Green M, Lowe J, Kadirvel M, McMahon A, Westwood N, Chua S, Brown G, Radiosynthesis of no-carrier-added meta-[124I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma. J Radioanal Nucl Chem 2017:311(1):727-32.   DOI
3 Olecki E, Grant CN. MIBG in neuroblastoma diagnosis and treatment. Semin Pediatr Surg 2019; 28(6):150859.
4 Rubio PM, Galan V, Rodado S, Plaza D, Martinez L. MIBG Therapy for Neuroblastoma: Precision Achieved With Dosimetry, and Concern for False Responders. Front Med (Lausanne) 2020;7:173.
5 Bombardieri E, Giammarile F, Aktolun C, Baum RP, Delaloye AB, Maffioli L, Moncayo R, Mortelmans L, Pepe G, Reske SN, Castellani MR, Chiti A. 131I/123I-metaiodobenzylguanidine (mIBG) scintigraphy: procedure guidelines for tumour imaging. Eur J Nucl Med Mol Imaging 2010;37(12): 2436-46.   DOI
6 Agrawal A, Rangarajan V, Shah S, Puranik A, Purandare N. MIBG (metaiodobenzylguanidine) theranostics in pediatric and adult malignancies. Br J Radiol 2018;91(1091):20180103.
7 Kolby L, Bernhardt P, Levin-Jakobsen A-M, Johanson V, Wangberg B, Ahlman H, Forssell-Aronsson E, Nilsson O. Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters. Br J Cancer 2003;89(7):1383-88.   DOI
8 Lopez Quinones AJ, Wagner D J, Wang J. Characterization of Meta-Iodobenzylguanidine (mIBG) Transport by Polyspecific Organic Cation Transporters: Implication for mIBG Therapy. Mol Pharmacol 2020;98(2):109-19.   DOI
9 Mangner TJ, Wu JL, Wieland DM. Solid-phase exchange radioiodination of aryl iodides. Facilitation by ammonium sulfate. J Org Chem 1982;47(8):1484-8.   DOI
10 Mock BH, Weiner RE. Simplified solid-state labeling of [123I]m-iodobenzylguanidine. Int J Rad Appl Instrum A 1988;39(9):939-42.   DOI
11 Wafelman AR, Konings MC, Hoefnagel CA, Maes RA, Beijnen JH. Synthesis, radiolabelling and stability of radioiodinated m-iodobenzylguanidine, a review. Appl Radiat Isot 1994;45(10):997-1007.   DOI
12 Tasdelen B, Kam E, Asliyuksek H. Quality control of iodine-131-labeled metaiodobenzylguanidine. Nucl Med Commun 2014;35(1):95-8.   DOI
13 Rossouw DD. Routine production and quality control of 123I-labelled mIBG at NAC. Int J Rad Appl Instrum A. 1992;43(10)1301-2.   DOI
14 Neves M, Paulo A, Patricio L. A kit formulation of [131I]meta-iodobenzylguanidine (MIBG) using Cu(I) generated "in situ" by sodium disulphite. Int J Rad Appl Instrum A. 1992;43(6):737-40.   DOI
15 Davarpanah MR, Nosrati SA, Khoshhosn HA, Fazlali M, Boudani MK. Establishment of a fast and high yield method for routine production of [131I]MIBG and investigation of its radiochemical stability for diagnosis and treatment uses. J Labelled Comp Radiopharm 2013; 56(13):686-8.   DOI
16 Rossouw DD, Macheli L. Large-scale synthesis of no-carrier-added [123I]mIBG, using two different stannylated precursors. J Labelled Comp Radiopharm 2009;52 2009;52(12): 499-503.   DOI
17 Vallabhajosula S, Nikolopoulou A. Radioiodinated Metaiodobenzylguanidine (MIBG): Radiochemistry, Biology, and Pharmacology. Semin Nucl Med 2011;41( 2011;41(5):324-33.   DOI
18 Prabhakar G, Mehra KS, Ramamoorthy N, Chattopadhyay S, Oommen R, Narasimhan S, Nair NA, Gunasekaran S. Evaluation of radioiodination of meta-iodobenzylguanidine (MIBG) catalysed by in situ generated Cu(I) and directly added Cu(II). Appl Radiat Isot 1999;50(6):1011-4.   DOI
19 Murhekar VV, Mathur A, Prabhakar G, Karkhanis BP, Pilkhwal NS, Tiwari BK, Padmanabhan D, Samuel G, Sachdev SS. Specific activity determination and stability studies of therapeutic 131I-mIBG radiopharmaceutical. J Radioanal Nucl Chem. 2014;302(2):883-8.   DOI