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http://dx.doi.org/10.22643/JRMP.2019.5.1.3

The development of a portable MO4- (M = 188Re or 99mTc) concentration device for extending the lifetime of RI generators  

Choi, Kang-Hyuk (Neutron and Radioisotope Application Research Division, Korea Atomic Energy Research Institute)
Park, Ul Jae (Neutron and Radioisotope Application Research Division, Korea Atomic Energy Research Institute)
Kim, Jong Bum (Neutron and Radioisotope Application Research Division, Korea Atomic Energy Research Institute)
Jang, Beom-Su (Research Division for Biotechnology, Korea Atomic Energy Research Institute)
Publication Information
Journal of Radiopharmaceuticals and Molecular Probes / v.5, no.1, 2019 , pp. 3-10 More about this Journal
Abstract
The activities per volume of $^{188}Re$ and $^{99m}Tc$ from their generators are dependent on the specific activity of their mother nuclides $^{188}W$ and $^{99}Mo$ respectively. After a particular lapse of time, the eluted RI activity is exponentially reduced and thus cannot satisfy the needs of clinical application. The purpose of this study is to develop a $^{188}Re$ and $^{99m}Tc$ concentration device with a compact size that can extend the period of use as well as conveniently concentrate the RI. We designed the concentration module by including two-different check valves that do not required any manual on-off operations. In these concentration process, cation exchange resin embedded with Ag and anion exchange resins were used. After completing the concentrating step, the recovering yield was identified to be more than 93% for $^{188}Re$ generators and 88% for $^{99m}Tc$ generators. Moreover, all these procedures were done within 5 min.
Keywords
RI concentration; Concentration device; Technetium-99m (Tc-99m); Rhenium-188 (Re-188); Validity period;
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