[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.22643/JRMP.2018.4.1.11

Development of fluorination methodology for carbon-fluorine bond formation: old electrophilic fluorinating reagents

Bae, Dae Young (Department of Chemistry, Pohang University of Science and Technology)
Lee, Eunsung (Department of Chemistry, Pohang University of Science and Technology)

Publication Information

Journal of Radiopharmaceuticals and Molecular Probes / v.4, no.1, 2018 , pp. 11-15 More about this Journal

Abstract

Electrophilic fluorinating reagents are typically efficient for carbon-fluorine (C-F) bonds formation due to their higher reactivity even under mild condition. Thus, they have been playing an important role to improve C-F bonds formation reactions via direct fluorination reaction with electrophilic fluorinating reagents or transition metal catalysis. Advances on the recent fluorination methods are mainly results of $Selectfluor^{TM}$ 's capability on facile fluorination. In this mini-review, we describe synthesis and application of four old yet popular electrophilic fluorinating reagents such as N-fluorobenzenesulfonimide (NFSI), N-fluoropyridinium salts, $Selectfluor^{TM}$ , and N-fluorosultam.

Keywords

Fluorination; Carbon-fluorine bond; Electrophilic fluorinating reagents; Catalysis;

Citations & Related Records

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