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http://dx.doi.org/10.22643/JRMP.2017.3.2.85

Fully automated radiosynthesis of [68Ga]edotreotide ([68Ga]DOTA-TOC) and its quality controls  

Park, Hyun Sik (Department of nuclear medicine, Seoul National University Bundang Hospital)
Lee, Hong Jin (Department of nuclear medicine, Seoul National University Bundang Hospital)
An, Hyun Ho (Department of nuclear medicine, Seoul National University Bundang Hospital)
Moon, Byung Seok (Department of nuclear medicine, Seoul National University Bundang Hospital)
Lee, Byung Chul (Department of nuclear medicine, Seoul National University Bundang Hospital)
Lee, Won Woo (Department of nuclear medicine, Seoul National University Bundang Hospital)
Kim, Sang Eun (Department of nuclear medicine, Seoul National University Bundang Hospital)
Publication Information
Journal of Radiopharmaceuticals and Molecular Probes / v.3, no.2, 2017 , pp. 85-90 More about this Journal
Abstract
$^{68}Ga-PET$ is of growing importance in the practice of nuclear medicine diagnostic imaging for neuroendocrine tumors as well as prostate cancers. Following this interests, we herein present the radiosynthesis process of [$^{68}Ga$]edotreotide ([$^{68}Ga$]DOTA-TOC) based on the fully automated procedure for clinical doses that can be provided the reduction of radiation exposure and high reproducibility. The quality controls of clinical doses in compliant with European Pharmacopoeia are also discussed.
Keywords
Gallium-68; [$^{68}Ga$]DOTATOC; [$^{68}Ga$]Edotreotide; Neuroendocrine tumor;
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1 Green MW, Tucker WD. An improved Gallium-68 cow. Int J Appl Radiat Isot 1961;12:62-63.   DOI
2 Nakayama M, Haratake M, Ono M, Koiso T, Harada K, Nakayama H, Yahara S, Ohmomo Y, Arano Y. A new 68Ge/68Ga generator system using an organic polymer containing N-methylglucamine groups as adsorbent for 68Ge. Appl Radiat Isot 2003;58:9-14.   DOI
3 Meyer GJ, Macke H, Schuhmacher J, Knapp WH, Hofmann M. 68Ga-labelled DOTA-derivatised peptide ligands. Eur J Nucl Med Mol Imaging 2004;31:1097-1104.
4 Zhernosekov KP, Filosofov DV, Baum RP, Aschoff P, Bihl H, Razbash AA, Jahn M, Jennewein M, Rosch F. Processing of generator-produced 68Ga for medical application. J Nucl Med 2007;48:1741-1748.   DOI
5 Breeman WAP, de Jong M, de Blois E, Bernard BF, Konijnenberg M, Krenning EP. Radiolabelling DOTApeptides with 68Ga. Eur J Nucl Med Mol Imaging 2005;32:478-485.   DOI
6 Decristoforo C, Knopp R, von Guggenberg E, Rupprich M, Dreger T, Hess A, Virgolini I, Haubner R. A fully automated synthesis for the preparation of $^{68}Ga$-labelled peptides. Nucl Med Commun 2007;28:870-875.   DOI
7 Hockley BG. Radiochemical syntheses, volume 1. Wiley; 2012, 321-334.
8 Hofmann M, Maecke H, Borner AR, Weckesser E, Schoffski P, Oei ML, Henze M, Heppeler A, Meyer GJ, Knapp WH. Biokinetics and imaging with the somatostatin receptor PET radioligand 68Ga-DOTATOC: preliminary data. Eur J Nucl Med 2001;28:1751-1757.   DOI
9 Breeman WA, de Jong M, Kwekkeboom DJ, Valkema R, Bakker WH, Kooij PP, Visser TJ, Krenning EP. Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives. Eur J Nucl Med 2001;28:1421-1429.   DOI
10 Al-Nahhas A, Win Z, Szyszko T, Singh A, Nanni C, Fanti S, Rubello D. Gallium-68 PET: a new frontier in receptor cancer imaging. Anticancer Res 2007;27:4087-4094.