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http://dx.doi.org/10.5653/cerm.2021.05071

Decorin: a multifunctional proteoglycan involved in oocyte maturation and trophoblast migration  

Park, Beom Seok (Department of Biomedical Laboratory Science, College of Health Science, Eulji University)
Lee, Jaewang (Department of Biomedical Laboratory Science, College of Health Science, Eulji University)
Jun, Jin Hyun (Department of Biomedical Laboratory Science, College of Health Science, Eulji University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.48, no.4, 2021 , pp. 303-310 More about this Journal
Abstract
Decorin (DCN) is a proteoglycan belonging to the small leucine-rich proteoglycan family. It is composed of a protein core containing leucine repeats with a glycosaminoglycan chain consisting of either chondroitin sulfate or dermatan sulfate. DCN is a structural component of connective tissues that can bind to type I collagen. It plays a role in the assembly of the extracellular matrix (ECM), and it is related to fibrillogenesis. It can interact with fibronectin, thrombospondin, complement component C1, transforming growth factor (TGF), and epidermal growth factor receptor. Normal DCN expression regulates a wide range of cellular processes, including proliferation, migration, apoptosis, and autophagy, through interactions with various molecules. However, its aberrant expression is associated with oocyte maturation, oocyte quality, and poor extravillous trophoblast invasion of the uterus, which underlies the occurrence of preeclampsia and intrauterine growth restriction. Spatiotemporal hormonal control of successful pregnancy should regulate the concentration and activity of specific proteins such as proteoglycan participating in the ECM remodeling of trophoblastic and uterine cells in fetal membranes and uterus. At the human feto-maternal interface, TGF-β and DCN play crucial roles in the regulation of trophoblast invasion of the uterus. This review summarizes the role of the proteoglycan DCN as an important and multifunctional molecule in the physiological regulation of oocyte maturation and trophoblast migration. This review also shows that recombinant DCN proteins might be useful for substantiating diverse functions in both animal and in vitro models of oogenesis and implantation.
Keywords
Decorin; Extracellular matrix; Implantation; Oocyte; Oogenesis; Proteoglycan; Trophoblasts;
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