Early fragment removal on in vitro fertilization day 2 significantly improves the subsequent development and clinical outcomes of fragmented human embryos |
Kim, Seok-Gi
(IVF Center, Mamapapa and Baby Clinic)
Kim, Youn-Young (IVF Center, Mamapapa and Baby Clinic) Park, Ji-Young (IVF Center, Mamapapa and Baby Clinic) Kwak, Su-Jin (IVF Center, Mamapapa and Baby Clinic) Yoo, Chang-Seok (IVF Center, Mamapapa and Baby Clinic) Park, Il-Hae (IVF Center, Mamapapa and Baby Clinic) Sun, Hong-Gil (IVF Center, Mamapapa and Baby Clinic) Kim, Jae-Won (IVF Center, Mamapapa and Baby Clinic) Lee, Kyeong-Ho (IVF Center, Mamapapa and Baby Clinic) Park, Hum-Dai (Department of Biotechnology, Daegu University) Chi, Hee-Jun (IVF Center, Mamapapa and Baby Clinic) |
1 | Salumets A, Suikkari AM, Mols T, Soderstrom-Anttila V, Tuuri T. Influence of oocytes and spermatozoa on early embryonic development. Fertil Steril 2002;78:1082-7. DOI |
2 | Giorgetti C, Terriou P, Auquier P, Hans E, Spach JL, Salzmann J, et al. Embryo score to predict implantation after in-vitro fertilization: based on 957 single embryo transfers. Hum Reprod 1995;10:2427-31. DOI |
3 | Keltz MD, Skorupski JC, Bradley K, Stein D. Predictors of embryo fragmentation and outcome after fragment removal in in vitro fertilization. Fertil Steril 2006;86:321-4. DOI |
4 | Phan V, Littman E, Harris D, La A. Correlation between embryo morphology and development and chromosomal complement. Asian Pac J Reprod 2014;3:85-9. DOI |
5 | Stensen MH, Tanbo TG, Storeng R, Abyholm T, Fedorcsak P. Fragmentation of human cleavage-stage embryos is related to the progression through meiotic and mitotic cell cycles. Fertil Steril 2015;103:374-81.e4. DOI |
6 | Jurisicova A, Varmuza S, Casper RF. Programmed cell death and human embryo fragmentation. Mol Hum Reprod 1996;2:93-8. DOI |
7 | Ebner T, Yaman C, Moser M, Sommergruber M, Polz W, Tews G. Embryo fragmentation in vitro and its impact on treatment and pregnancy outcome. Fertil Steril 2001;76:281-5. DOI |
8 | Otasevic V, Surlan L, Vucetic M, Tulic I, Buzadzic B, Stancic A, et al. Expression patterns of mitochondrial OXPHOS components, mitofusin 1 and dynamin-related protein 1 are associated with human embryo fragmentation. Reprod Fertil Dev 2016;28:319-27. DOI |
9 | Alikani M, Calderon G, Tomkin G, Garrisi J, Kokot M, Cohen J. Cleavage anomalies in early human embryos and survival after prolonged culture in-vitro. Hum Reprod 2000;15:2634-43. DOI |
10 | Alikani M, Cohen J, Tomkin G, Garrisi GJ, Mack C, Scott RT. Human embryo fragmentation in vitro and its implications for pregnancy and implantation. Fertil Steril 1999;71:836-42. DOI |
11 | Van Blerkom J, Davis P, Alexander S. A microscopic and biochemical study of fragmentation phenotypes in stage-appropriate human embryos. Hum Reprod 2001;16:719-29. DOI |
12 | Antczak M, Van Blerkom J. Temporal and spatial aspects of fragmentation in early human embryos: possible effects on developmental competence and association with the differential elimination of regulatory proteins from polarized domains. Hum Reprod 1999;14:429-47. DOI |
13 | Lewin A, Schenker JG, Safran A, Zigelman N, Avrech O, Abramov Y, et al. Embryo growth rate in vitro as an indicator of embryo quality in IVF cycles. J Assist Reprod Genet 1994;11:500-3. DOI |
14 | Ziebe S, Petersen K, Lindenberg S, Andersen AG, Gabrielsen A, Andersen AN. Embryo morphology or cleavage stage: how to select the best embryos for transfer after in-vitro fertilization. Hum Reprod 1997;12:1545-9. DOI |
15 | Tasdemir M, Tasdemir I, Kodama H, Fukuda J, Tanaka T. Two instead of three embryo transfer in in-vitro fertilization. Hum Reprod 1995;10:2155-8. DOI |
16 | Veeck LL, Rosenwaks Z. An atlas of human gametes and conceptuses: an illustrated reference for assisted reproductive technology. New York: Parthenon; 1999. |
17 | Isik AZ, Gaglar GS, Sozen E, Tuncay G, Vicdan K. The effect of assisted hatching and defragmentation on IVF outcome in patients without good quality embryos for transfer. J Turk Soc Obstet Gynecol 2013;10:138-42. DOI |
18 | Chi HJ, Koo JJ, Choi SY, Jeong HJ, Roh SI. Fragmentation of embryos is associated with both necrosis and apoptosis. Fertil Steril 2011;96:187-92. DOI |
19 | Staessen C, Camus M, Bollen N, Devroey P, Van Steirteghem AC. The relationship between embryo quality and the occurrence of multiple pregnancies. Fertil Steril 1992;57:626-30. DOI |
20 | Eftekhari-Yazdi P, Valojerdi MR, Ashtiani SK, Eslaminejad MB, Karimian L. Effect of fragment removal on blastocyst formation and quality of human embryos. Reprod Biomed Online 2006;13:823-32. DOI |
21 | Keltz M, Fritz R, Gonzales E, Ozensoy S, Skorupski J, Stein D. Defragmentation of low grade day 3 embryos resulted in sustained reduction in fragmentation, but did not improve compaction or blastulation rates. Fertil Steril 2010;94:2406-8. DOI |
22 | Baart EB, Martini E, Eijkemans MJ, Van Opstal D, Beckers NG, Verhoeff A, et al. Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Hum Reprod 2007;22:980-8. DOI |
23 | Chi HJ, Kim SG, Kim YY, Park JY, Yoo CS, Park IH, et al. ICSI significantly improved the pregnancy rate of patients with a high sperm DNA fragmentation index. Clin Exp Reprod Med 2017;44:132-40. DOI |
24 | Yang HW, Hwang KJ, Kwon HC, Kim HS, Choi KW, Oh KS. Detection of reactive oxygen species (ROS) and apoptosis in human fragmented embryos. Hum Reprod 1998;13:998-1002. DOI |
25 | Chi HJ, Koo JJ, Lee JO, Ryu HE, Kim KR, Park C, et al. Effect of fragment removal on development of human fragmented embryos in IVF-ET program. Korean J Reprod Med 2010;37:339-48. |
26 | Bongso A, Ng SC, Lim J, Fong CY, Ratnam S. Preimplantation genetics: chromosomes of fragmented human embryos. Fertil Steril 1991;56:66-70. DOI |
27 | Halvaei I, Khalili MA, Safari S, Esfandiari N. Ongoing pregnancies following cosmetic micromanipulation of preimplantation embryos in patients with implantation failure. Case Rep Med 2015; 2015:734793. |
28 | Halvaei I, Khalili MA, Esfandiari N, Safari S, Talebi AR, Miglietta S, et al. Ultrastructure of cytoplasmic fragments in human cleavage stage embryos. J Assist Reprod Genet 2016;33:1677-84. DOI |
![]() |