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http://dx.doi.org/10.5653/cerm.2013.40.2.95

Association between serum anti-M$\ddot{u}$llerian hormone level and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome  

Kim, Ju Yeong (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital)
Yi, Gwang (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital)
Kim, Yeo Rang (Department of Obstetrics and Gynecology, Seoul National University Hospital)
Chung, Jae Yeon (Department of Obstetrics and Gynecology, Seoul National University Hospital)
Ahn, Ji Hyun (Department of Obstetrics and Gynecology, Seoul National University Hospital)
Uhm, You Kyoung (Department of Obstetrics and Gynecology, Seoul National University Hospital)
Jee, Byung Chul (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital)
Suh, Chang Suk (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital)
Kim, Seok Hyun (Department of Obstetrics and Gynecology, Seoul National University Hospital)
Publication Information
Clinical and Experimental Reproductive Medicine / v.40, no.2, 2013 , pp. 95-99 More about this Journal
Abstract
Objective: To evaluate the correlation between serum levels of anti-M$\ddot{u}$llerian hormone (AMH) and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome (PCOS). Methods: Seventy-four cycles of mild stimulation (clomiphene citrate+gonadotropin followed by timed intercourse or intrauterine insemination) performed in normoovulatory women (57 cycles) and anovulatory women with PCOS (17 cycles). Ovarian sensitivity was defined by the number of mature follicles (${\geq}14mm$) on triggering day per 100 IU of gonadotropin. A correlation between ovarian sensitivity and the baseline serum AMH level (absolute or multiples of the median [MoM] value for each corresponding age) was calculated. Correlation between ovarian response and serum AMH level was evaluated. Results: Ovarian sensitivity to mild stimulation was positively correlated with absolute serum AMH (r=0.535, p<0.001) or AMH-MoM value (r=0.390, p=0.003) in normoovulatory women, but this correlation was not observed in anovulatory women with PCOS (r=0.105, p>0.05, r=-0.265, p>0.05, respectively). Conclusion: Ovarian response to mild stimulation is possibly predicted by the serum AMH level in normoovulatory women, but not in anovulatory women with PCOS.
Keywords
Anti-M$\ddot{u}$llerian hormone; Ovarian stimulation; Polycystic ovary syndrome;
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1 Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA, et al. Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod 2004;10:77-83.   DOI
2 Chen MJ, Yang WS, Chen CL, Wu MY, Yang YS, Ho HN. The relationship between anti-Mullerian hormone, androgen and insulin resistance on the number of antral follicles in women with polycystic ovary syndrome. Hum Reprod 2008;23:952-7.   DOI
3 Fanchin R, Schonauer LM, Righini C, Frydman N, Frydman R, Taieb J. Serum anti-Mullerian hormone dynamics during controlled ovarian hyperstimulation. Hum Reprod 2003;18:328-32.   DOI
4 Anckaert E, Smitz J, Schiettecatte J, Klein BM, Arce JC. The value of anti-Mullerian hormone measurement in the long GnRH agonist protocol: association with ovarian response and gonadotrophin- dose adjustments. Hum Reprod 2012;27:1829-39.   DOI
5 Catteau-Jonard S, Pigny P, Reyss AC, Decanter C, Poncelet E, Dewailly D. Changes in serum anti-mullerian hormone level during low-dose recombinant follicular-stimulating hormone therapy for anovulation in polycystic ovary syndrome. J Clin Endocrinol Metab 2007;92:4138-43.   DOI
6 Twigt JM, Hammiche F, Sinclair KD, Beckers NG, Visser JA, Lindemans J, et al. Preconception folic acid use modulates estradiol and follicular responses to ovarian stimulation. J Clin Endocrinol Metab 2011;96:E322-9.   DOI
7 van Rooij IA, Broekmans FJ, te Velde ER, Fauser BC, Bancsi LF, de Jong FH, et al. Serum anti-Mullerian hormone levels: a novel measure of ovarian reserve. Hum Reprod 2002;17:3065-71.   DOI
8 Lee JE, Lee JR, Jee BC, Suh CS, Kim KC, Lee WD, et al. Clinical application of anti-Mullerian hormone as a predictor of controlled ovarian hyperstimulation outcome. Clin Exp Reprod Med 2012; 39:176-81.   DOI
9 Seifer DB, MacLaughlin DT, Christian BP, Feng B, Shelden RM. Early follicular serum mullerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertil Steril 2002;77:468-71.   DOI
10 Eldar-Geva T, Ben-Chetrit A, Spitz IM, Rabinowitz R, Markowitz E, Mimoni T, et al. Dynamic assays of inhibin B, anti-Mullerian hormone and estradiol following FSH stimulation and ovarian ultrasonography as predictors of IVF outcome. Hum Reprod 2005;20: 3178-83.   DOI
11 Pellatt L, Hanna L, Brincat M, Galea R, Brain H, Whitehead S, et al. Granulosa cell production of anti-Mullerian hormone is increased in polycystic ovaries. J Clin Endocrinol Metab 2007;92:240-5.   DOI
12 Pigny P, Merlen E, Robert Y, Cortet-Rudelli C, Decanter C, Jonard S, et al. Elevated serum level of anti-mullerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest. J Clin Endocrinol Metab 2003; 88:5957-62.   DOI
13 Wang JG, Nakhuda GS, Guarnaccia MM, Sauer MV, Lobo RA. Mullerian inhibiting substance and disrupted folliculogenesis in polycystic ovary syndrome. Am J Obstet Gynecol 2007;196:77.e1-5.   DOI
14 Lin YH, Chiu WC, Wu CH, Tzeng CR, Hsu CS, Hsu MI. Antimullerian hormone and polycystic ovary syndrome. Fertil Steril 2011;96: 230-5.   DOI
15 Catteau-Jonard S, Jamin SP, Leclerc A, Gonzales J, Dewailly D, di Clemente N. Anti-Mullerian hormone, its receptor, FSH receptor, and androgen receptor genes are overexpressed by granulosa cells from stimulated follicles in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2008;93:4456-61.   DOI
16 Li Y, Wei LN, Liang XY. Follicle-stimulating hormone suppressed excessive production of antimullerian hormone caused by abnormally enhanced promoter activity in polycystic ovary syndrome granulosa cells. Fertil Steril 2011;95:2354-8.   DOI
17 Dewailly D, Gronier H, Poncelet E, Robin G, Leroy M, Pigny P, et al. Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries. Hum Reprod 2011;26:3123-9.   DOI
18 Ocal P, Sahmay S, Cetin M, Irez T, Guralp O, Cepni I. Serum anti- Mullerian hormone and antral follicle count as predictive markers of OHSS in ART cycles. J Assist Reprod Genet 2011;28:1197-203.   DOI
19 Amer S, Mahran M, Eissa M, Darne J, Shaw R. P-500: the influence of circulating anti-müllerian hormone on ovarian responsiveness to ovulation induction with FSH in women with polycystic ovarian syndrome. Hum Reprod 2012;27:ii344-8.
20 Mahran A, Abdelmeged A, El-Adawy A, Eissa M, Darne J, Shaw RW, et al. P-493: the predictive value of measuring circulating anti-müllerian hormone in women with polycystic ovary syndrome receiving clomiphene citrate. Hum Reprod 2012;27:ii344-8.
21 Durlinger AL, Gruijters MJ, Kramer P, Karels B, Ingraham HA, Nachtigal MW, et al. Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology 2002;143:1076-84.   DOI
22 Durlinger AL, Gruijters MJ, Kramer P, Karels B, Kumar TR, Matzuk MM, et al. Anti-Mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary. Endocrinology 2001; 142:4891-9.   DOI
23 Pellatt L, Rice S, Dilaver N, Heshri A, Galea R, Brincat M, et al. Anti- Mullerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells. Fertil Steril 2011;96: 1246-51.e1.   DOI
24 Rotterdam EA-SPCWG. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
25 Webber LJ, Stubbs S, Stark J, Trew GH, Margara R, Hardy K, et al. Formation and early development of follicles in the polycystic ovary. Lancet 2003;362:1017-21.   DOI
26 Jonard S, Robert Y, Cortet-Rudelli C, Pigny P, Decanter C, Dewailly D. Ultrasound examination of polycystic ovaries: is it worth counting the follicles? Hum Reprod 2003;18:598-603.   DOI
27 La Marca A, Papaleo E, Grisendi V, Argento C, Giulini S, Volpe A. Development of a nomogram based on markers of ovarian reserve for the individualisation of the follicle-stimulating hormone starting dose in in vitro fertilisation cycles. BJOG 2012;119:1171-9.   DOI
28 Lee JY, Jee BC, Lee JR, Kim CH, Park T, Yeon BR, et al. Age-related distributions of anti-Mullerian hormone level and anti-Mullerian hormone models. Acta Obstet Gynecol Scand 2012;91:970-5.   DOI