Browse > Article
http://dx.doi.org/10.5653/cerm.2012.39.4.127

Transcription factors in the maintenance and survival of primordial follicles  

Lim, Eun-Jin (Department of Biomedical Science, CHA University)
Choi, Youngsok (Department of Biomedical Science, CHA University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.39, no.4, 2012 , pp. 127-131 More about this Journal
Abstract
Primordial follicles are formed prenatally in mammalian ovaries, and at birth they are fated to be activated to primary follicles, to be dormant, or to die. During the early stage of folliclulogenesis, the oocyte undergoes dynamic alterations in expression of numerous genes, which are regulated by transcription factors. Several germ-cell specific transcriptional regulators are critical for formation and maintenance of follicles. These transcriptional regulators include: Figla, Lhx8, Nobox, Sohlh1, and Sohlh2. A subset of these transcriptional regulators is mutated in women with ovarian insufficiency and infertility. Establishment of this oocyte pool is essential for fertility. This review focuses on these transcriptional regulators of female primordial follicles.
Keywords
Primordial follicles; Transcription factors; Figla; Lhx8; Nobox; Sohlh1; Sohlh2;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Toyoda S, Miyazaki T, Miyazaki S, Yoshimura T, Yamamoto M, Tashiro F, et al. Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia. Dev Biol 2009;325:238-48.   DOI
2 Barrios F, Filipponi D, Campolo F, Gori M, Bramucci F, Pellegrini M, et al. SOHLH1 and SOHLH2 control Kit expression during postnatal male germ cell development. J Cell Sci 2012;125:1455-64.   DOI
3 Ding X, Zhang X, Mu Y, Li Y, Hao J. Effects of BMP4/SMAD signaling pathway on mouse primordial follicle growth and survival via up-regulation of Sohlh2 and c-kit. Mol Reprod Dev 2012 Dec 4 [Epub]. http://dx.doi.org/10.1002/mrd.22138.
4 Suzuki H, Ahn HW, Chu T, Bowden W, Gassei K, Orwig K, et al. SOHLH1 and SOHLH2 coordinate spermatogonial differentiation. Dev Biol 2012;361:301-12.   DOI
5 Bayne RA, Martins da Silva SJ, Anderson RA. Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary. Mol Hum Reprod 2004;10:373-81.   DOI
6 Suzumori N, Yan C, Matzuk MM, Rajkovic A. Nobox is a homeobox- encoding gene preferentially expressed in primordial and growing oocytes. Mech Dev 2002;111:137-41.   DOI
7 Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM. NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science 2004;305:1157-9.   DOI
8 Choi Y, Rajkovic A. Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters. J Biol Chem 2006;281:35747-56.   DOI
9 Choi M, Lee OH, Jeon S, Park M, Lee DR, Ko JJ, et al. The oocytespecific transcription factor, Nobox, regulates the expression of Pad6, a peptidylarginine deiminase in the oocyte. FEBS Lett 2010; 584:3629-34.   DOI
10 Tsunemoto K, Anzai M, Matsuoka T, Tokoro M, Shin SW, Amano T, et al. Cis-acting elements (E-box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte-specific gene expression in the mouse. Mol Reprod Dev 2008;75:1104-8.   DOI
11 Qin Y, Choi Y, Zhao H, Simpson JL, Chen ZJ, Rajkovic A. NOBOX homeobox mutation causes premature ovarian failure. Am J Hum Genet 2007;81:576-81.   DOI
12 Mori T, Yuxing Z, Takaki H, Takeuchi M, Iseki K, Hagino S, et al. The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. Eur J Neurosci 2004; 19:3129-41.   DOI
13 Zhao Y, Guo YJ, Tomac AC, Taylor NR, Grinberg A, Lee EJ, et al. Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8. Proc Natl Acad Sci U S A 1999;96:15002-6.   DOI
14 Zhao Y, Marin O, Hermesz E, Powell A, Flames N, Palkovits M, et al. The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proc Natl Acad Sci U S A 2003;100:9005-10.   DOI
15 Choi Y, Ballow DJ, Xin Y, Rajkovic A. Lim homeobox gene, lhx8, is essential for mouse oocyte differentiation and survival. Biol Reprod 2008;79:442-9.   DOI
16 Choi Y, Qin Y, Berger MF, Ballow DJ, Bulyk ML, Rajkovic A. Microarray analyses of newborn mouse ovaries lacking Nobox. Biol Reprod 2007;77:312-9.   DOI
17 Menke DB, Koubova J, Page DC. Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave. Dev Biol 2003;262:303-12.   DOI
18 Baltus AE, Menke DB, Hu YC, Goodheart ML, Carpenter AE, de Rooij DG, et al. In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. Nat Genet 2006;38:1430-4.   DOI
19 McKAY DG, Hertig AT, Adams EC, Danziger S. Histochemical observations on the germ cells of human embryos. Anat Rec 1953; 117:201-19.   DOI
20 Choi Y, Yuan D, Rajkovic A. Germ cell-specific transcriptional regulator sohlh2 is essential for early mouse folliculogenesis and oocyte-specific gene expression. Biol Reprod 2008;79:1176-82.   DOI
21 Baker TG. A quantitative and cytological study of germ cells in human ovaries. Proc R Soc Lond B Biol Sci 1963;158:417-33.   DOI
22 McGee EA, Hsueh AJ. Initial and cyclic recruitment of ovarian follicles. Endocr Rev 2000;21:200-14.
23 Oktem O, Urman B. Understanding follicle growth in vivo. Hum Reprod 2010;25:2944-54.   DOI
24 Choi Y, Rajkovic A. Genetics of early mammalian folliculogenesis. Cell Mol Life Sci 2006;63:579-90.   DOI
25 Liang L, Soyal SM, Dean J. FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes. Development 1997;124:4939-47.
26 Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, et al. Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A 2006;103:8090-5.   DOI
27 Soyal SM, Amleh A, Dean J. FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation. Development 2000;127:4645-54.
28 Joshi S, Davies H, Sims LP, Levy SE, Dean J. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. BMC Dev Biol 2007;7:67.   DOI
29 Hu W, Gauthier L, Baibakov B, Jimenez-Movilla M, Dean J. FIGLA, a basic helix-loop-helix transcription factor, balances sexually dimorphic gene expression in postnatal oocytes. Mol Cell Biol 2010; 30:3661-71.   DOI
30 Zhao H, Chen ZJ, Qin Y, Shi Y, Wang S, Choi Y, et al. Transcription factor FIGLA is mutated in patients with premature ovarian failure. Am J Hum Genet 2008;82:1342-8.   DOI