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http://dx.doi.org/10.5653/cerm.2011.38.1.6

Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility  

Lee, Sun-Hee (Department of Biomedical Science, College of Life Science, CHA University)
Lee, Su-Man (Department of Biomedical Science, College of Life Science, CHA University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.38, no.1, 2011 , pp. 6-9 More about this Journal
Abstract
Objective: To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility. Methods: We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping. Results: The SNP of the KLK2 gene had a statistically significant association with male infertility (p<0.05). The odds ratio for the minor allele (+255A) in the pooled sample was 0.47 (95% confidence intervals, 0.26-0.85) for rs2664155. Conclusion: The relationship of KLK2 SNP to male infertility is statistically significant, especially within the non-azoospermia group. Further study is needed to understand the mechanisms associated with male infertility.
Keywords
Kallikrein-related Peptidase 2; Polymorphism, Single Nucleotide; Infertility, Male; Human;
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