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http://dx.doi.org/10.5653/cerm.2011.38.1.1

Small GTPases and formins in mammalian oocyte maturation: cytoskeletal organizers  

Kwon, So-Jung (Department of Biomedical Science & Technology, Institute of Biomedical Science & Technology, Research Center for Transcription Control, Konkuk University)
Lim, Hyun-Jung J. (Department of Biomedical Science & Technology, Institute of Biomedical Science & Technology, Research Center for Transcription Control, Konkuk University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.38, no.1, 2011 , pp. 1-5 More about this Journal
Abstract
The maturation process of mammalian oocytes accompanies an extensive rearrangement of the cytoskeleton and associated proteins. As this process requires a delicate interplay between the cytoskeleton and its regulators, it is often targeted by various external and internal adversaries that affect the congression and/or segregation of chromosomes. Asymmetric cell division in oocytes also requires specific regulators of the cytoskeleton, including formin-2 and small GTPases. Recent literature providing clues regarding how actin filaments and microtubules interact during spindle migration in mouse oocytes are highlighted in this review.
Keywords
Oocyte; Spindle; Formin; GTP Phosphohydrolases; Human; Mice;
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