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Stem Cell Based Strategies for the Treatment of Degenerative Retinal Diseases  

Park, Jung-Hyun (Department of Ophthalmology, Seoul Paik Hospital, Inje University)
Ku, Seung-Yup (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University)
Cho, Myung-Soo (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University)
Lee, Hak-Sup (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University)
Choi, Young-Min (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University)
Moon, Shin-Yong (Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University)
Yu, Hyeong-Gon (Department of Ophthalmology, Seoul National University College of Medicine)
Publication Information
Clinical and Experimental Reproductive Medicine / v.37, no.3, 2010 , pp. 199-206 More about this Journal
Abstract
Stem-cell therapy has the potential to improve vision in patients with untreatable retinal disease. Various types of cell source including fetal, embryonic and adult stem cells, intrinsic and extrinsic factors for differentiation into retinal progenitors and transplantation mode were discussed in this review. Experimental approaches have successfully induced photoreceptor precursor cells and retinal pigment epithelium. Stem-cell-based therapy is a promising treatment to restore vision in patients with retinal disease, in spite of the challenges.
Keywords
Stem cells; Stem cell transplantation; Retinal degeneration; Retinal pigment epithelium; Photoreceptor cells;
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1 Wang HC, Brown J, Alayon H, Stuck BE. Transplantation of quantum dot-labelled bone marrow-derived stem cells into the vitreous of mice with laser-induced retinal injury: survival, integration and differentiation. Vision Res 2010; 50: 665-73.   DOI   ScienceOn
2 Mears AJ, Kondo M, Swain PK, Takada Y, Bush RA, Saunders TL, et al. Nrl is required for rod photoreceptor development. Nat Genet 2001; 29: 447-52.   DOI   ScienceOn
3 Haider NB, Jacobson SG, Cideciyan AV, Swiderski R, Streb LM, Searby C, et al. Mutation of a nuclear receptor gene NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate. Nat Genet 2000; 24: 127-31.   DOI   ScienceOn
4 Sakaguchi DS, Van Hoffelen SJ, Theusch E, Parker E, Orasky J, Harper MM, et al. Transplantation of neural progenitor cells into the developing retina of the Brazilian opossum: an in vivo system for studying stem/progenitor cell plasticity. Dev Neurosci 2004; 26: 336-45.   DOI   ScienceOn
5 Lamba DA, Karl MO, Ware CB, Reh TA. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc Natl Acad Sci USA 2006; 103: 12769-74.   DOI   ScienceOn
6 Banin E, Obolensky A, Idelson M, Hemo I, Reinhardtz E, Pikarsky E, et al. Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells. Stem Cells 2006; 24: 246-57.   DOI   ScienceOn
7 Bradbury EJ, McMahon SB. Spinal cord repair strategies: why do they work? Nat Rev Neurosci 2006; 7: 644-53.   DOI
8 Lu B, Malcuit C, Wang S, Girman S, Francis P, Lemieux L, et al. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration. Stem Cells 2009; 27: 2126-35.   DOI   ScienceOn
9 Lund RD, Wang S, Klimanskaya I, Holmes T, Ramos-Kelsey R, Lu B, et al. Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats. Cloning Stem Cells 2006; 8: 189-99.   DOI   ScienceOn
10 Li SY, Yin ZQ, Chen SJ, Chen LF, Liu Y. Rescue from light-induced retinal degeneration by human fetal retinal transplantation in minipigs. Curr Eye Res 2009; 34: 523-35.   DOI   ScienceOn
11 Filbin MT. Recapitulate development to promote axonal regeneration: good or bad approach? Philos Trans R Soc Lond B Biol Sci 2006; 361: 1565-74.   DOI   ScienceOn
12 Sugie Y, Yoshikawa M, Ouji Y, Saito K, Moriya K, Ishizaka S, et al. Photoreceptor cells from mouse ES cells by co-culture with chick embryonic retina. Biochem Biophys Res Commun 2005; 332: 241-7.   DOI   ScienceOn
13 Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, Pokharel GP, et al. Global data on visual impairment in the year 2002. Bull World Health Organ 2004; 82: 844-51.
14 Klassen H, Lund RD. Retinal transplants can drive a pupillary reflex in host rat brains. Proc Natl Acad Sci USA 1987; 84: 6958-60.   DOI   ScienceOn
15 Maclaren RE, Taylor JS. Regeneration in the developing optic nerve: correlating observations in the opossum to other mammalian systems. Prog Neurobiol 1997; 53: 381-98.   DOI   ScienceOn
16 MacLaren RE, Taylor JS. Chiasmatic specificity in the regenerating mammalian optic nerve. Exp Neurol 1997; 147: 279-86.   DOI   ScienceOn
17 Takahashi M, Palmer TD, Takahashi J, Gage FH. Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol Cell Neurosci 1998; 12: 340-8.   DOI   ScienceOn
18 Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N, et al. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol 2008; 26: 215-24.   DOI   ScienceOn
19 Klimanskaya I, Hipp J, Rezai KA, West M, Atala A, Lanza R. Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. Cloning Stem Cells 2004; 6: 217-45.
20 Gong J, Sagiv O, Cai H, Tsang SH, Del Priore LV. Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors. Exp Eye Res 2008; 86: 957-65.   DOI   ScienceOn
21 MacLaren RE, Pearson RA, MacNeil A, Douglas RH, Salt TE, Akimoto M, et al. Retinal repair by transplantation of photoreceptor precursors. Nature 2006; 444: 203-7.   DOI   ScienceOn
22 tani A, Dorrell MI, Kinder K, Moreno SK, Nusinowitz S, Banin E, et al. Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells. J Clin Invest 2004; 114: 765-74.   DOI
23 Francis PJ, Wang S, Zhang Y, Brown A, Hwang T, McFarland TJ, et al. Subretinal transplantation of forebrain progenitor cells in nonhuman primates: survival and intact retinal function. Invest Ophthalmol Vis Sci 2009; 50: 3425-31.   DOI   ScienceOn
24 Ikeda H, Osakada F, Watanabe K, Mizuseki K, Haraguchi T, Miyoshi H, et al. Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci USA 2005; 102: 11331-6.   DOI   ScienceOn
25 Bradford RL, Wang C, Zack DJ, Adler R. Roles of cellintrinsic and microenvironmental factors in photoreceptor cell differentiation. Dev Biol 2005; 286: 31-45.   DOI   ScienceOn
26 Chacko DM, Rogers JA, Turner JE, Ahmad I. Survival and differentiation of cultured retinal progenitors transplanted in the subretinal space of the rat. Biochem Biophys Res Commun 2000; 268: 842-6.   DOI   ScienceOn
27 Coles BL, Angenieux B, Inoue T, Del Rio-Tsonis K, Spence JR, McInnes RR, et al. Facile isolation and the characterization of human retinal stem cells. Proc Natl Acad Sci USA 2004; 101: 15772-7.   DOI   ScienceOn
28 Wang S, Lu B, Wood P, Lund RD. Grafting of ARPE-19 and Schwann cells to the subretinal space in RCS rats. Invest Ophthalmol Vis Sci 2005; 46: 2552-60.   DOI   ScienceOn
29 Pellegrini G, De Luca M, Arsenijevic Y. Towards therapeutic application of ocular stem cells. Semin Cell Dev Biol 2007; 18: 805-18.   DOI   ScienceOn
30 Furukawa T, Morrow EM, Cepko CL. Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation. Cell 1997; 91: 531-41.   DOI   ScienceOn
31 Tsonis PA, Fuentes EJ. Focus on molecules: Pax-6, the eye master. Exp Eye Res 2006; 83: 233-4.   DOI   ScienceOn
32 Ferda Percin E, Ploder LA, Yu JJ, Arici K, Horsford DJ, Rutherford A, et al. Human microphthalmia associated with mutations in the retinal homeobox gene CHX10. Nat Genet 2000; 25: 397-401.   DOI   ScienceOn
33 Young MJ, Ray J, Whiteley SJ, Klassen H, Gage FH. Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Mol Cell Neurosci 2000; 16: 197-205.   DOI   ScienceOn
34 Vugler A, Lawrence J, Walsh J, Carr A, Gias C, Semo M, et al. Embryonic stem cells and retinal repair. Mech Dev 2007; 124: 807-29.   DOI   ScienceOn
35 Chen J, Rattner A, Nathans J. The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes. J Neurosci 2005; 25: 118-29.   DOI   ScienceOn