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The Comparison of Pregnancy Outcomes between Elective Two and Three Cleavage-state Embryos Transfer in Fresh IVF-ET  

Lyu, Sang-Woo (Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, College of Medicine, CHA University)
Won, Hyung-Jae (Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, College of Medicine, CHA University)
Lee, Woo-Sik (Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, College of Medicine, CHA University)
Han, Ji-Eun (Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, College of Medicine, CHA University)
Kim, A-Ri (Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, College of Medicine, CHA University)
Kim, You-Shin (Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, College of Medicine, CHA University)
Seok, Hyun-Ha (Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, College of Medicine, CHA University)
Yoon, Tae-Ki (Fertility Center of CHA Gangnam Medical Center, Department of Obstetrics and Gynecology, College of Medicine, CHA University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.37, no.1, 2010 , pp. 65-72 More about this Journal
Abstract
Objective: To compare the respective pregnancy outcomes of cycles undergoing elective two cleavage-stage embryos transfer (2ET) and three cleavage-stage embryos transfer (3ET) in fresh in vitro fertilization and embryo transfer (IVF-ET) program. Methods: We conducted a retrospective matched case control study that included 100 women with 2ET and 100 women with 3ET from January 2007 to June 2009. Subjects were matched for reproductive profiles and cycle characteristics. All of transferred embryos in both groups had good qualities. Pregnancy rates (PR), implantation rate, and multiple PR were compared. Results: Demographics, stimulation parameters and embryological data were comparable in both groups. Main pregnancy outcomes with 2ET and 3ET groups were not statistically different; implantation rate (41.0% vs. 35.3%), positive pregnancy rate (58.0% vs. 60.0%), clinical PR (55.0% vs. 59.0%), ongoing PR (51.0% vs. 55.0%), respectively. However, the 3ET group showed significantly higher multiple pregnancy and triplet pregnancy rates (30.9% vs. 50.8%, p=0.031; 1.8% vs. 11.9%, p=0.036, respectively). Conclusion: In women with favorable conditions and good quality embryos undergoing IVF, 2ET can get pregnancy outcomes comparable to those of 3ET and reduce multiple pregnancy (especially, triplet pregnancy).
Keywords
In vitro fertilization; 2 day Embryo transfer; 3 day Embryo transfer; Pregnancy outcome; Multiple pregnancy;
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1 Tur R, Coroleu B, Torello MJ, Boada M, Veiga A, Barri PN. Prevention of multiple pregnancy following IVF in Spain. Reprod Biomed Online 2006; 13: 856-63.   DOI   ScienceOn
2 Thurin A, Hausken J, Hillensjo T, Jablonowska B, Pinborq A, Strandell A, et al. Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization. N Engl J Med 2004: 351; 2392-402.   DOI   ScienceOn
3 Henman M, Catt JW, Wood T, Bowman MC, de Boer KA, Jansen RP. Elective transfer of single fresh blastocysts and later transfer of cryostored blastocysts reduces the twin pregnancy rate and can improve the in vitro fertilization live birth rate in younger women. Fertil Steril 2005; 84: 1620-7.   DOI   ScienceOn
4 Styer AK, Wriqht DL, Wolkovich AM, Veiqa C, Toth TL. Single-blastocyst transfer decreases twin gestation without affecting pregnancy outcome. Fertil Steril 2008; 89: 1702-8.   DOI   ScienceOn
5 민응기. 2006-7 불임부부지원사업의 결과 및 변화. 대한보조생식학회 제 12차 학술대회; 2008 Aug 30; 117-32.
6 Berqh C. Single embryo transfer: a mini review. Hum Reprod 2005; 20: 323-7.   DOI
7 Dean NL, Phillips SJ, Buckett WM, Biljan MM, Tan SL. Impact of reducing the number of embryos transferred from three to two in women nuder the age of 35 who produced three or more high-quality embryos. Fertil Steril 2000; 74: 820-3.   DOI   ScienceOn
8 Komori S, Kasumi H, Horiuchi I, Hamada Y, Suzuki C, Shiqeta M, et al. Prevention of multiple pregnancies by restricting the number of transferred embryos: randomized control study. Arch Gynecol Obstet 2004; 270: 91-3.
9 Blake DA, Farquhar CM, Johnson N, Proctor M. Cleavage stage versus blastocyst stage embryo transfer in assisted conception (Review). Cochrane Database Syst Rev. 2007;CD002118.
10 Papanikolaou EG, Camus M, Kolibianakis EM, Van Landuyt L, Van Steirteqhem A, Devroey P. In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos. N Engl J Med 2006; 354: 1139-46.   DOI   ScienceOn
11 Templeton A, Morris JK. Reducing the risk of multiple births by transfer of two embryos after in vitro fertilization. N Engl J Med 1998; 339: 573-7.   DOI   ScienceOn
12 Criniti A, Thyer A, Chow G, Lin P, Klein N, Soules M. Elective single blastocyst transfer reduces twin rates without compromising pregnancy rates. Fertil Steril 2005; 84: 1613-9.   DOI   ScienceOn
13 Staessen C, Janssenswillen C, Van Den Abbeel E, Devroey P, Van Steirteqhem AC. Avoidance of triplet pregnancies by elective transfer of two good quality embryos. Hum Reprod 1993; 8: 1650-3.   DOI
14 Tasdemir M, Tasdemir I, Kodama H, Fukuda J, Tanaka K. Two instead of three embryo transfer in in-vitro fertilization. Hum Reprod 1995; 10: 2155-8.   DOI
15 Seoud MA, Toner JP, Kruithoff C, Muasher SJ. Outcome of twin, triplet and quadruplet in-vitro fertilisation pregnancies: the Norfolk experience. Fertil Steril 1992; 57: 825-34.   DOI
16 Lieberman B. An embryo too many? Hum Reprod 1998; 13: 2664-6.   DOI   ScienceOn
17 Stromberg B, Dahlquist G, Ericson A, Finnstrom O, Koster M, Stjernqvist K. Neurological sequelae in children born after in vitro fertilisation: a population based study. Lancet 2002; 359 -65.
18 Nijs M, Geerts L, van Roosendaal E, Seqal-Bertin G, Vanderzwalmen P, Schoysman R. Prevention of multiple pregnancies in an in vitro fertilization program. Fertil Steril 1993; 59: 1245-50.   DOI
19 Society for Assisted Reproductive Technology and the American Society for Reproductive Medicine. 1998 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproductive Technology Registry. Fertil Steril 2002; 77: 18-31.   DOI   ScienceOn
20 Martin PM, Welch HG. Probabilities for singleton and multiple pregnancies after in vitro fertilization. Fertil Steril 1998; 70: 478-81.   DOI   ScienceOn
21 Yokoyama Y, Shimizu T, Hayakawa K. Incidence of handicaps in multiple births and associated factors. Acta Genet Med Gemellol 1995; 81-91.