Browse > Article

Outcome of Gonadotropin Therapy for Infertile Men with Hypogonadotropic Hypogonadism  

Joo, Young-Min (Department of Urology, Cheil General Hospital, Kwandong University College of Medicine)
Kim, Tae-Hong (Department of Urology, Cheil General Hospital, Kwandong University College of Medicine)
Seo, Ju-Tae (Department of Urology, Cheil General Hospital, Kwandong University College of Medicine)
Publication Information
Clinical and Experimental Reproductive Medicine / v.36, no.3, 2009 , pp. 219-224 More about this Journal
Abstract
Objective: Hypogonadotropic hypogonadism (HH) is an uncommon cause of male infertility. We investigated the outcome of gonadotropin therapy for restoring fertility and pregnancy outcomes in patients with HH. Methods: Medical charts of 10 infertile male patients with HH treated with gonadotropin were reviewed. Initial testicular volume were estimated. Semen analysis parameters (semen volume, sperm counts, motility), serum leutenizing hormone (LH), follicle stimulating hormone (FSH), total testosterone were determined before and after human chorionic gonadotropin/human menopausal gonadotropin (hCG/hMG) treatment. Differences were analyzed statistically. Results: Of 10 patients, 7 (70%) succeed at pregnancy (nature pregnancy in 4). Semen analysis parameters, serum FSH, and testosterone were increased significantly after treatment. The population was stratified according to initial testicular volume into a small testis subset (testicular volume less than 10 cc in 4) and a large testis subset (testicular volume 10 cc or greater in 6). Semen analysis parameters and serum testosterone were increased significantly after treatment in large testis subset. Conclusion: Infertile men with HH initiate and maintain spermatogenesis with gonadotropin (hCG/hMG alone or combined) therapy, thus gonadotropin therapy is good choice in infertile men with HH.
Keywords
Hypogonadotropic hypogonadism; Gonadotropin; Fertility; Pregnancy outcome;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Sigman M, Jarow JP. Male Infertility. In Walsh PC, Retik AB, Vanghan ED Jr, Wein A. Jc, editors. Campbell's Urology 9th ed, Philadelphia: Saunders, 2007; 609-53
2 Miyagawa Y, Tsujimura A, Matsumiya K, Takao T, Tohda A, Koga M, et al. Outcome of gonadotropin therapy for male hypogonadotropic hypogonadism at university affiliated male infertility centers: a 30-year retrospective study. J Urol 2005; 173: 2072-5   DOI   ScienceOn
3 Buchter D, Behre HM, Kliesch S, Nieschlag E. Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. Eur J Endocrinol 1998; 139: 298-303   DOI   ScienceOn
4 Rey RA, Campo SM, Bedecarras P, Nagle CA, Chemes HE. Is infancy a quiescent period of testicular development? Histological, morphometric, and functional study of the seminiferous tubules of the cebus monkey from birth to the end of puberty. J Clin Endocrinol Metab 1993; 76: 1325-31   DOI   ScienceOn
5 Russell LD, Bartke A, Goh JC. Postnatal development of the Sertoli cell barrier, tubular lumen, and cytoskeleton of Sertoli and myoid cells in the rat, and their relationship to tubular fluid secretion and flow. Am J Anat 1989; 184: 179-89   DOI   ScienceOn
6 Vicari E, Mongioi A, D'Agta R. Gonadotropin replacement therapy in patients with hypogonadotropic hypogonadism. Ann N Y Acad Sci 1984; 438: 454-8   DOI   PUBMED
7 Bardin CW. Male Hypogonadism. In: Yen SSC, Jaffe RB, editors. Reproductive Endocrinology, Physiology, Pathophysiology and Clinical Management. 2nd ed. Philadelphia: Saunders; 1986; 614-30
8 Matsumoto AM. Hormonal therapy of male hypogonadism. Endocrinol Metab Clin North Am 1994; 23: 857-75   PUBMED
9 D'Agta R, Vicari E, Allifi A, Mauqeri G, Monqioi A, Gulizia S. Tesiticular responsiveness to chronic human chorionic gonadotropin administration in hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1982; 55: 76-80   DOI   PUBMED
10 American association of clinical endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients-2002 update. Endocrine practice 2002; 8: 439-56   DOI
11 Burris AS, Rodbard HW, Winters SJ, Sherins RJ. Gonadotropin therapy in men with isolated hypogonadotropic hypogonadism: the response to human chorionic gonadotropin is predicted by initial testicular size. J Clin Endocrinol Metab 1988; 66: 1144-51   DOI   PUBMED
12 Sigman M, Jarow JP. Endocrine evaluation of infertile men. Urology 1997; 50: 659-64   DOI   PUBMED   ScienceOn