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Directed Differentiation of Human Embryonic Stem cells into Transplantable Hepatocytes: Recent Progress and Future Directions  

Woo, Dong-Hun (Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University)
Kim, Jong-Hoon (Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University)
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Clinical and Experimental Reproductive Medicine / v.36, no.3, 2009 , pp. 143-150 More about this Journal
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1 Rambhatla L, Chiu C, Kundu P, Peng Y, Carpenter MK. Generation of hepatocyte-like cells from human embryonic stem cells. Cell Transplant 2003; 12: 1-11   DOI   ScienceOn
2 Baharvand H, Piryaei A, Rohani R, Taei A, Heidari MH, Hosseini A, et al. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int J Dev Biol 2006; 50: 645-52   DOI   ScienceOn
3 Baharvand H, Hashemi SM, Shahsavani M. Differentiation of human embryonic stem cells into functional hepatocyte-like cells in a serum-free adherent culture condition. Differentiation 2008; 76: 465-77   DOI   ScienceOn
4 Blyszczuk P, Czyz J, Kania G, Wagner M, Roll U, St-Onge L, et al. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulinproducing cells. Proc Natl Acad Sci U S A 2003; 100: 998-1003   DOI   ScienceOn
5 Chowdhury JR, Grossman M, Gupta S, Chowdhury NR, Baker JR, Wilson JM. Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits. Science 1991; 254: 1802-5   DOI   PUBMED
6 Gunsalus JR, Brady DA, Coulter SM, Gray BM, Edge AS. Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nat Med 1997; 3: 48-53   DOI   ScienceOn
7 Cho SW, Moon SH, Lee SH, Kang SW, Kim J, Lim JM, et al. Improvement of postnatal neovascularization by human embryonic stem cell derived endothelial-like cell transplantation in a mouse model of hindlimb ischemia. Circulation 2007; 116: 2409-19   DOI   ScienceOn
8 Lu P, Jones LL, Snyder EY, Tuszynski MH. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol 2003; 181: 115-29   DOI   ScienceOn
9 Fraser SE, Harland RM, The molecular metamorphosis of experimental embryology. Cell 2000; 100: 41-55   DOI   ScienceOn
10 Hay DC, Zhao D, Fletcher J, Hewitt ZA, McLean D, Urruticoechea-Uriguen A, et al. Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo. Stem Cells 2008; 26: 894-902   DOI   ScienceOn
11 Lee WM. Drug-induced hepatotoxicity. N Engl J Med 1995; 333: 1118-27   DOI   ScienceOn
12 Basma H, Soto-Gutierrez A, Yannam GR, Ito R, Yamamoto T, Ellis E, et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology 2009; 136: 990-9   DOI   ScienceOn
13 Habibullah CM, Syed IH, Qamar A, Taher-Uz Z. Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 1994; 58: 951-2   DOI   ScienceOn
14 Zhao D, Chen S, Cai J, Guo Y, Song Z, et al. Derivation and characterization of hepatic progenitor cells from human embryonic stem cells. PLoS One 2009; 4: e6468   DOI   PUBMED   ScienceOn
15 Lee WM. Acute liver failure. Am J Med 1994; 96: 3S-9S   PUBMED
16 Lake JR. Hepatocyte transplantation. N Engl J Med 1998; 338: 1463-5   DOI   ScienceOn
17 D'Amour KA, Agulnic AD, Eliazer S, Kelly OG, Kroon E, Baetge EE. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 2005; 23: 1534-41   DOI   ScienceOn
18 Shirahashi H, Wu J, Yamamoto N, Catana A, Wege H, Wager B, et al. Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage. Cell Transplant 2004; 13: 197-211   DOI   ScienceOn
19 Lavon N, Yanuka O, Benvenisty N. Differentiation and isolation of hepatic-like cells from human embryonic stem cells. Differentiation 2004; 72: 230-8   DOI   ScienceOn
20 Strom SC, Fisher RA, Thompson MT, Sanyal AJ, Cole PE, Ham JM, Posner MP. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation 1997; 63: 559-69   DOI   ScienceOn
21 Hay DC, Fletcher J, Payne C, Terrace JD, Gallagher RC, Snoeys J, et al. Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Proc Natl Acad Sci U S A 2008; 105: 12301-6   DOI   ScienceOn
22 Zaret KS. Regulatory phases of early liver development: paradigms of organogenesis. Nat Rev Genet 2002; 3: 499-512   DOI   PUBMED   ScienceOn
23 Fox IJ, Chowdhury JR Kaufman SS Goertzen TC Chowdhury, NR, Warkentin PI, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 1998; 338: 1422-6   DOI   ScienceOn
24 Formigli L, Perna AM, Meacci E, Cinci L, Margheri M, Nistri S. Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling. J Cell Mol Med 2007; 11: 1087-100   DOI   ScienceOn
25 Wilson JM, Chowdhury NR, Grossman M, Wajsman R, Epstein A, Mulligan RC. Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes. Proc Natl Acad Sci U S A 1990; 87: 8437-41   DOI   ScienceOn
26 Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, et al. Repopulation Efficiencies of Adult Hepatocytes, Fetal Liver Progenitor Cells, and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice. Am J Pathol 2009. Aug 28. [Epub ahead of print]   DOI   ScienceOn
27 Duan Y, Catana A, Meng Y, Yamamoto N, He S, Gupta S, et al. Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo. Stem Cells 2007; 25: 3058-68   DOI   ScienceOn
28 Uemura R, Xu M, Ahmad N, Ashraf M, Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res 2006; 98: 1414-21   DOI   ScienceOn
29 Cai J, Liu Y, Ye F, Song Z, Qin H, Meng S, et al. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology 2007; 45: 1229-39   DOI   ScienceOn
30 Fukuda H, Takahashi J, Watanabe K, Hayashi H, Morizane A, Koyanagi M, et al. Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells 2006; 24: 763-71   DOI   ScienceOn
31 Hay DC, Zhao D, Ross A, Mandalam R, Lebkowski J, Cui W. Direct differentiation of human embryonic stem cells to hepatocyte-like cells exhibiting functional activities. Cloning Stem Cells 2007; 9: 51-62   DOI   ScienceOn
32 Grossman M, Raper SE, Kozarsky K, Stein EA, Engelhardt JF, Muller D, et al. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet 1994; 6: 335-41   DOI   ScienceOn