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Association between Endometriosis and Human ${\alpha}2$-Heremans Schmidt Glycoprotein (AHSG) Polymorphism  

Kim, Jin-Ju (Department of Obstetrics and Gynecology, Seoul National University College of Medicine)
Chae, Soo-Jin (Department of Obstetrics and Gynecology, Maria Fertility Hospital)
Kim, Jong-Mee (Department of Obstetrics and Gynecology, Seoul National University College of Medicine)
Lee, Gyoung-Hoon (Department of Obstetrics and Gynecology, Gachon University Gil Medical Center)
Choi, Young-Min (Department of Obstetrics and Gynecology, Seoul National University College of Medicine)
Kim, Sung-Hoon (Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center)
Shin, Jung-Ho (Department of Obstetrics and Gynecology, Korea University College of Medicine)
Lee, Taek-Hoo (Department of Obstetrics and Gynecology, Kyungpook National University School of Medicine)
Hur, Jun-Young (Department of Obstetrics and Gynecology, Korea University College of Medicine)
Lee, Byoung-Suk (Department of Obstetrics and Gynecology, Yonsei University College of Medicine)
Oh, Sung-Tack (Department of Obstetrics and Gynecology, Chonnam National University College of Medicine)
Lee, Kyu-Sup (Department of Obstetrics and Gynecology, Pusan National University College of Medicine and Medical Research Institute, Pusan National University)
Lim, Young-Tack (Department of Obstetrics and Gynecology, St Vincent's Hospital, College of Medicine, Catholic University of Korea)
Publication Information
Clinical and Experimental Reproductive Medicine / v.35, no.4, 2008 , pp. 267-274 More about this Journal
Abstract
Objective: To evaluate the relationship between advanced stage endometriosis and polymorphisms in $\alpha$2-Heremans Schmidt glycoprotein (AHSG) gene in Korean women. Methods: One-hundred thirty women with endometriosis stage III and IV, and 224 women without endometriosis were enrolled. In these patients, we determined AHSG gene polymorphisms by PCR and RFLP (restriction fragment length polymorphism) analysis. Results: The genotype distribution of the AHSG gene polymorphism in the endometriosis group was not different from that of the control group (AHSG 1*1/AHSG 1*2/AHSG 2*2 frequencies were 56.2%/37.7%/6.2% and 55.8%/39.3%/4.9% for the endometriosis and control groups, respectively, p=.864). Also, the frequency of AHSG 2 haplotype was not different between endometriosis patients and controls (AHSG 1 haplotype /AHSG 2 haplotype rates were 75.0%/25.0% and 75.4%/24.6% for the endometriosis and control groups, respectively, p=0.894). Conclusion: AHSG gene polymorphism was not associated with the risk of advanced stage endometriosis in the Korean population.
Keywords
Endometriosis; AHSG; Polymorphism;
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