Browse > Article

The Clinical Significance of Serum Vascular Endothelial Growth Factor Levels Measured at Ovulation Triggering Day In Intrauterine Insemination Cycles  

Kim, Hyun-Jun (Department of Obstetrics and Gynecology, College of Medicine, Konkuk University)
Jee, Byung-Chul (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital)
Suh, Chang-Suk (Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital)
Kim, Seok-Hyun (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University)
Choi, Young-Min (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University)
Kim, Jung-Gu (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University)
Moon, Shin-Yong (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.34, no.1, 2007 , pp. 33-39 More about this Journal
Abstract
Objective: The objective of this study was to investigate whether serum levels of vascular endothelial growth factor (VEGF) measured at ovulation triggering day reflect ovarian response in intrauterine insemination (IUI) cycles. Methods: Forty-nine fertile women who undergoing superovulation and IUI were included. Superovulation was performed using clomiphene citrate (100 mg/d on day 3$\sim$7) in combination with human menopausal gonadotropin (150 IU every other day starting on day 5). Serum samples were obtained on the day of hCG administration and the levels of VEGF-A and estradiol were measured. The numbers of mature follicle $\geq$17 mm in diameter were also counted. Results: Serum VEGF-A levels did not correlate with the numbers of mature follicle count nor serum estradiol levels. Serum estradiol level was positively associated with mature follicle count. Serum VEGF-A levels tended to be lower in women with mature follicle count less than three or women with more than five. Conclusion: Our results indicate that serum VEGF-A levels do not have an association with superovulation outcome in IUI cycles. However, a tendency of lower VEGF-A level in poor and high responder suggests that those with extreme response to superovulation may be related with abnormal angiogenesis. Further studies should be warranted in larger populations.
Keywords
Vascular endothelial growth factor; Intrauterine insemination; Superovulation;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Ferrara N, Houck K, Jakeman L, Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of polypeptides. Endocr Rev 1992; 13: 18-32   DOI   PUBMED
2 Lee A, Buny KA, Christenson LK, Patton PE, Stouffer RL. Vascular endothelial growth factor levels in serum and follicular fluid of patients undergoing in vitro fertilization. Fertil Steril 1997; 68: 305-11   DOI   ScienceOn
3 Malamitsi-Puchner A, Sarandakou A, Baka S, Hasiakos D, Kouskouni E, Creatsas G. In vitro fertilization: angiogenic, proliferative, and apoptotic factors in the follicular fluid. Ann N Y Acad Sci 2003; 997: 124-8   DOI   PUBMED   ScienceOn
4 Laitinen M, Ristimaki A, Honkasalo M, et al. Differential hormonal regulation of vascular endothelial growth factors VEGF, VEGF-B, and VEGF-C messenger ribonucleic acid expression in the primate ovary. Endocrinology 1992; 131: 254-60   DOI   ScienceOn
5 Ferrara N, Houck K, Jakeman L, Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of polypeptides. Endocr Rev 1992; 13: 18-32   DOI   PUBMED
6 Kaczmarek MM, Schams D, Ziecik AJ. Role of vascular endothelial growth factor in ovarian physiology - an overview. Reprod Biol 2005; 5: 111-36   PUBMED
7 Geva E, Jaffe RB. Role of vascular endothelial growth factor in ovarian physiology and pathology. Fertil Steril 2000; 74: 429-38   DOI   ScienceOn
8 Kim KH, Oh DS, Jeong JH, Shin BS, Joo BS, Lee KS. Follicular blood flow is a better predictor of the outcome of in vitro fertilization-embryo transfer than follicular fluid vascular endothelial growth factor and nitric oxide concentrations. Fertil Steril 2004; 82: 586-92   DOI   ScienceOn
9 Barroso G, Barrionuevo M, Rao P, Graham L, Danforth D, Huey S, Abuhamad A, Oehninger S. Vascular endothelial growth factor, nitric oxide, and leptin follicular fluid levels correlate negatively with embryo quality in IVF patients. Fertil Steril 1999; 72: 1024-6   DOI   PUBMED   ScienceOn
10 Dvorak HE Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002; 20: 4368-80   DOI   ScienceOn
11 Mttioli M, Barhoni B, Turriani M, Galeati G, Zannoni A, Castellani G, Berardinelli P, Scapolo PA. Follicle activation involves vascular endothelial growth factor production and increased blood vessel extension. Biol Reprod 2001; 65: 1014-9   DOI   ScienceOn
12 Quintana R, Kopcow L, Marconi G, Sueldo C, Speranza G, Baranao RI. Relationship of ovarian stimulation response with vascular endothelial growth factor and degree of granulosa cell apoptosis. Hum Reprod 2001; 16: 1814-8   DOI   ScienceOn
13 Van Blerkom J. Intrafollicular influences on human oocyte developmental competence: perifollicular vascularity, oocyte metabolism and mitochondrial function. Hum Reprod 2000; 15 suppl 2: 173-88   PUBMED
14 Carmeliet P, Ferreira V, Bereier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380: 435-9   DOI   ScienceOn
15 Benifla JL, Bringuier AF, Sifer C, Porcher R, Madelenat P, Feldmann G. Vascular endothelial growth factor, platelet endothelial cell adhesion molecule-1 and vascular cell adhesion molecule-1 in the follicular fluid of patients undergoing IVF. Hum Reprod 2001; 16: 1376-81   DOI   ScienceOn
16 Barboni B, Turriani M, Galeati G, Spinaci M, Bacci ML, Forni M, Mattioli M. Vascular endothelial growth factor production in growing pig antral follicles. Biol Reprod 2000; 63: 858-64   DOI   ScienceOn
17 Ocal P, Aydin S, Cepni I, Idil S, Idil M, Uzun H, Benian A. Follicular fluid concentrations of vascular endothelial growth factor, inhibin A and inhibin B in IVF cycles: are they markers for ovarian response and pregnancy outcome? Eur J Obstet Gynecol Reprod Biol 2004; 115: 194-9   DOI   ScienceOn
18 Moncayo HE, Penz-Koza A, Marth C, Gastl G, Herold M, Moncayo R. Vacular endothelial growh factor in serum and in the follicular fluid of patients undergoing hormonal stimulation for in-vitro fertilization. Hum Reprod 1998; 13: 3310-4   DOI   ScienceOn
19 Friedman CI, Seifer DB, Kennard EA, Arbogast L, Alak B, Danforth DR. Elevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential. Fertil Steril 1998; 70: 836-9   DOI   ScienceOn
20 Friedman CI, Danforth DR, Herbosa-Encarnacion C, Arbogast L, Alak BM, Seifer DB. Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction. Fertil Steril 1997; 68: 607-12   DOI   ScienceOn
21 Iijima K, Jiang JY, Shimizu T, Sasada H, Sato E. Acceleration of follicular development by administration of vascular endothelial growth factor in cycling female rats. J Reprod Dev 2005; 51: 161-8   DOI   ScienceOn
22 Dom C, Reinsberg J, Kupka M, van der Ven H, Schild RL. Leptin, VEGF, IGF-l, and IGFBP-3 concentrations in serum and follicular fluid of women undergoing in vitro fertilization. Arch Gynecol Obstet 2003; 268: 187-93   DOI   ScienceOn
23 Peter L, Vassili R, Silke L,Tanja W, Ernst S, Ludwig W. Cycle dependency of intrauterine vascular endothelial growth factor levels is correlated with decidualization and corpus luteum function. Fertil Steril 2003; 80: 1228-33
24 Ferrara N, Carver-Moore K, Chen H, et al. Heterozygous embryonic lethally induced by targeted inactivation of the VEGF gene. Nature 1996; 380: 439-42.   DOI   ScienceOn