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Risk Factors Related to Uterine Leiomyoma in Korean Women - A Retrospective Study -  

Hong, D.G. (Department of Obstetrics and Gynecology, Kyungpook National University, School of Medicine)
Chung, M.J. (Department of Obstetrics and Gynecology, Kyungpook National University, School of Medicine)
Kim, B.S. (Department of Obstetrics and Gynecology, Kyungpook National University, School of Medicine)
Lee, J.M. (Department of Obstetrics and Gynecology, Kyungpook National University, School of Medicine)
Cho, Y.L. (Department of Obstetrics and Gynecology, Kyungpook National University, School of Medicine)
Lee, T.H. (Department of Obstetrics and Gynecology, Kyungpook National University, School of Medicine)
Chun, S.S. (Department of Obstetrics and Gynecology, Kyungpook National University, School of Medicine)
Publication Information
Clinical and Experimental Reproductive Medicine / v.33, no.3, 2006 , pp. 159-170 More about this Journal
Abstract
Objective: The purpose of this study is to find out risk factors related to uterine leiomyoma in Korean women and to compare with the results of previous western studies. Methods: A retrospective analysis was carried out. All the cases of uterine leiomyoma (n=244) were diagnosed surgically or sonographically between Jannuary 1998 and December 2004. Total of 269 controls not having uterine leiomyoma were collected from patients who visited Kyungpook national university hospital for routine gynecologic check-up or treatment of their gynecologic or obstetric diseases other than uterine leiomyoma. Data were collected through review of medical records and interviews and analyzed with $x^2$ and logistic regression model. Results: In multivariate analysis, patient's age (OR 1.070; 95% CI 1.041~1.099), number of artificial abortion (OR 1.182; 95% CI 1.018~1.374) and alcohol drinking (OR 1.865; 95% CI 1.231~2.824) had significantly positive correlation with uterine leiomyoma. The duration of lactation was the only factor which had negative correlation (OR 0.985; 95% CI 0.972~0.998). BMI, parity, age at menarche, the duration and interval of menstruation, caffeine consumption and marital status did not show any correlations. Conclusion: In this study, patient's age, number of artificial abortion, and alcohol drinking were the risk factors of uterine leiomyoma in Korean women and the result was similar to that of western studies. Though we couldn't find out the specific risk factors related to the development of uterine leiomyoma in this study, but it has a great meaning to be the first trial in Korean women. The role of information bias should be carefully evaluated and further multicentered, randomized, controlled prospective studies will be needed to know the possible risk factors among Korean women.
Keywords
Uterine leiomyoma; Risk factor; Korean women;
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1 Singletary KW, Gapstur SM. Alcohol and breast cancer: review of epidemiologic and experitmental evidence and potential mechanisms. JAMA 2001; 286(17): 2143-51   DOI   ScienceOn
2 Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, et al. Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the black women's health study. Human Reproduction 2004; 19(8): 1746 -54   DOI   ScienceOn
3 Cauley JA, Gutai JP, Kuller LH, LeDonne D, Powell JG. The epidemiology of serum sex hormones in postmenopausal women. Am J Epidemiol 1989; 129: 1120-31   DOI
4 Lucero J, Harlow BL, Barbieri RL, Sluss P, Cramer DW. Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use. Fertil Steril 2001; 76(4): 723-9   DOI   ScienceOn
5 Ross R. Factors influencing atherogenesis. In: Hurst JW, Schlant RC, Sonnenblick EH, et al. The heart, arteries, and veins. 7th ed. New York, NY: McGraw-Hill Book Compan, 1990; 877-92
6 Yam D. Insulin-cancer relationships: possible dietary implication. Med Hypotheses 1992; 38: 111-7   DOI   ScienceOn
7 Flake GP, Darlene Dixon JA. Etiology and pathogenesis of uterine leiomyomas: A review. Environmental Health Perspectives 2003; 111(8): 1037-54
8 Miller NF, Ludovici. On the origin and development of uterine fibroids. Am J Obstet Gynecol 1955; 70: 720-40   DOI
9 Lorraine D, Philippen L, Henry B, Janet G. Sexuality. Am J Med 2005; 118(12B): 595-635
10 Parazzini F, La Vecchia C, Negri E, Cecchetti G, Fedele L. Eidemiologic characteristics of women with uterine fibroids: a case-control study. Obstet Gynecol 1998; 72(6): 853-7
11 Kawaguchi K, Fujii S, Iwai T, Nanbu Y, Nonogaki H, Konishi I, et al. Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy. Virchows Arch A Pathol Anat Histopathol 1991; 419: 309-15   DOI
12 Samdi AR, Lee NC, Flanders WD, Boring JR 3rd, Parris EB. Risk factors for self-reported uterine fibroids: a case-control study. Am J Public Health 1996; 86(6): 858-62   DOI   ScienceOn
13 Reichlin S. Prolactin and growth hormone secretion in stress. Adv Exp Med Biol 1988; 245: 353-76
14 Sato F, Nishi M, Kudo R, Miyake H. Body fat distribution and uterine leiomyomas. J Epidemiol 1998; 8(3): 176-80   DOI   ScienceOn
15 Rong H, Boterberg T, Maubach J, Stove C, Depypere H, Serreyn R, et al. 8-Prenylnaringenin in hops and beer, upregulates the function of the E- cadherin/ catenin complex in human mammary carcinoma cells. Eur J Cell Biol 2001; 80(9): 580-5   DOI   ScienceOn
16 Torpin R, Pund E, Peepies WJ. The etiologic and pathologic factors in a series of 1741 fibromyomas of the uterus. Am J Obstet Gynecol 1942; 44: 569   DOI
17 Windham GC, Elkin E, Fenster L, Waller K, Anderson M, Mitchell PR, et al. Ovarian hormones in premenopausal women: variation by demographic, reproductive and menopausal cycle characteristics. Epidemiology 2002; 13(6): 675-84   DOI   ScienceOn
18 Wise LA, Palmer JR, Stewart EA, Rosenberg L. Age-Specific Incidence Rates for Self-Reported Uterine Leiomyomata in the Black Women's Health Study 2005; 105: 563-8   DOI
19 Chiaffarino F, Parazzini F, La Vecchia C, Chatenoud L, Di Cintio E, Marsico S. Diet and uterine myomas. Obstet Gynecol 1999; 94: 395-8   DOI
20 Eduardo F, Moyses S, Neil B. Risk factors for leiomyoma: a practice-based case-control study. II Atherogenic risk factors and potential sources of uterine irritation. Am J Epid 2001; 153(1): 11-9   DOI   ScienceOn
21 Leonard TK, Watson RP, Mohs ME. The effects of caffeine on various systems: a review. J Am Diet Assoc 1987; 87: 1048-53
22 Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-campbell LL, et al. Reproductive factors, hormonal contraception, and risk of uterine leiomyomata in African-American women: a prospective study. Am J Epid 2004; 159(2): 113-23   DOI
23 Apter D, Vinhko R. Early menarche, a risk factor for breast cancer, indicates early onset of ovulatory cycles. J Clin Endocrinol Metab 1983; 57: 82-6   DOI
24 Rosemary B, Sandra L, Lori B, Leonard D, Jean F, Kerstin F, et al. Revised definitions of women's sexual dysfuction. J Sex Med 2004; 1(1): 40-8   DOI   ScienceOn
25 Shikora SA, Niloff JM, Bistrian BR, Forse RA, Black-burn GL. Relationship between obesity and uterine leiomyomata. Nutrition 1991; 7(4): 251-5   DOI
26 Lumbiganon P, Rugpao S, Phandhu-fung S, Laopaiboon M, Vudhikamraksa N, Werawatakul Y. Protective effect of depot-medroxyprogesterone acetate on surgically treated uterine leiomyomas: a multicentre case-control study. Br J Obstet Gynaecol 1996; 103(9): 909-14   DOI
27 Chiaffarino F, Parazzini F, Vecchia C, Marsico S, Surace M, Ricci E. Use of oral contraceptives and uterine fibroids: results from a case-control study. J Obstet Gynecol 1999; 106(8): 857-60
28 Mora S, Diehl T, Stewart EA. Prolactin in an autocrine growth regulator for human myometrial and leiomyoma women. J Soc Gynecol Invest 1995; 2: 396
29 Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olsen F. Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas. Am J Obstet Gynecol 2002; 186: 409-15   DOI   ScienceOn
30 Marshall LM, Spiegelman D, Goldman MB, Manson JE, Colditz GA, Barbieri RL, et al. A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. Fertil Steril 1998; 70(3): 432-9   DOI   ScienceOn
31 Soyka M, Gorig E, Naber D. Serum prolactin increase induced by ethanol- a dose dependent effect not related to stress. Psychoneuroendocrinology 1991; 16(5): 441-6   DOI   ScienceOn
32 Graystone JT, Kuo CC, Campell LA, Benditt EP. Chlamydia pneumoniae, strain TWAR and atherosclerosis. Eur Heart J 1993; 14: 66-71
33 Marshall LM, Spiegelman D, Mannson JE. Risk of uterine leiomyomata among premenopausal women in relation to body size and cigarette smoking. Epidemiology 1998; 9(5): 511-7   DOI   ScienceOn
34 Walnut Creek Contraceptive Drug Study. A prospective Study of the Side Effect of Oral Contraceptives. Bethesda, MD: National Institute of Health, 1981
35 Benson RC, Pernoll MM. Benson and Pernoll's handbook of obstetrics and gynecology. 9th ed. New York, NY: McGraw Hill Book Company, 1994
36 Anderson J. Growth factor and cytokines in uterine leimyomas. Semin Reprod Endocrinol 1996; 14: 269-82
37 Eduardo F, Moyses S, Neil B. Risk factors for leiomyoma: a practice-based case-control study. II Atherogenic risk factors and potential sources of uterine irritation. Am J Epid 2001; 153(1): 11-9   DOI   ScienceOn
38 Bernstein L, Pike MC, Ross PK, Judd HL, Brown JB, Henderson BE. Estrogen and sex hormone-binging globulin levels in nulliparous and parous women. J Natl Cancer Inst 1985; 74(4): 741-5
39 Walker CL, Cesen-Cumming K, Houle C. Protective effect of pregnancy for development of uterine leiomyoma. Carcinogenesis 2001; 22: 2049-52   DOI   ScienceOn
40 Reichman ME, Judd JT, Longgeope C, Schatzkin A, Clevidence BA, Nair PP, et al. Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women. J Natl Cancer Inst 1993; 85(9): 692-3   DOI   ScienceOn