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The Clinical Efficiency of Clomiphene Citrate vs Clomiphene Citrate/GnRH Antagonist on Infertile Women with Normal Ovulatory Cycles  

Lee, Woo Seok (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University)
Sang, Jae Hong (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University)
Kim, Jae Joon (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University)
Kim, Gwang June (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University)
Kim, Dong Ho (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University)
Lee, Sang Hun (Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.33, no.3, 2006 , pp. 149-157 More about this Journal
Abstract
Objective: This study was to investigate the clinical efficiency of clomiphene citrate/GnRH antagonist protocol comparing with the clomiphene citrate only protocol in infertile women with normal ovulatory cycles. Method: Among 116 patients, 43 were received assisted reproductive technologies using natural ovulatory cycle, 38 and 35 were received clomiphene citrate only protocol and clomiphene citrate/GnRH antagonist combined protocol, respectively, and the clinical results were compared and analyzed Results: In each group, basal levels of LH, FSH, $E_2$ and FSH, $E_2$ on hCG day injected were not different, but LH level and endometrial thickness on hCG injected day were decreased significantly and the pregnancy rate was increased significantly in clomiphene citrate/GnRH antagonist group. Conclusion: The pregnancy rate was increased significantly in clomiphene citrate/GnRH antagonist group compared with natural ovulatory cycle and clomiphene citrate only group.
Keywords
Clomiphene citrate; GnRH antagonist;
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