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Association of the COMT Gene Polymorphism with the Risk of PCOS in Korean Women  

Lee, Ji Young (Department of Obstetrics and Gynecology, College of Medicine, Konkuk University)
Cha, Yun Jeong (Department of Obstetrics and Gynecology, College of Medicine, Konkuk University)
Hur, Seung Eun (Department of Obstetrics and Gynecology, College of Medicine, Konyang University)
Kwon, Han Sung (Department of Obstetrics and Gynecology, College of Medicine, Konkuk University)
Lee, Sun-Joo (Department of Obstetrics and Gynecology, College of Medicine, Konkuk University)
Sohn, In Sook (Department of Obstetrics and Gynecology, College of Medicine, Konkuk University)
Kim, Soo Nyung (Department of Obstetrics and Gynecology, College of Medicine, Konkuk University)
Seung, Yon A (Department of Internal Medicine, College of Medicine, Ewha Womans University)
Chung, Hye Won (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.33, no.2, 2006 , pp. 97-104 More about this Journal
Abstract
Objective: To investigate whether polymorphism of Catechol-O-methyltransferase(COMT) gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women. Methods: One hundred and thirty-six PCOS patients and eighty four controls were enrolled. Blood samples were collected from the patients diagnosed according to the 2003 revised criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Age matched women with regular menstruation from same geographic region were recruited as control subject. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype. Results: In women with $COMT^{LL}$ genotype, there was decreased PCOS risk and this difference was statistically significant (OR 0.24, 95% CI 0.11~0.51). Conclusion: The results suggest that the $COMT^{LL}$ genetic polymorphism might be associated with PCOS risk in Korean women.
Keywords
COMT; PCOS; Polymorphism;
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