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The histologic features of the uterus and adnexa extirpated from gender identity disorder patients with depot androgen injection  

Byun, Jae Chun (Department of Obstetrics and Gynecology, College of Medicine, Dong-A University)
Kwak, Bong Gyu (Department of Obstetrics and Gynecology, College of Medicine, Dong-A University)
Shin, Ji Hyun (Department of Obstetrics and Gynecology, College of Medicine, Dong-A University)
Cha, Moon Seok (Department of Obstetrics and Gynecology, College of Medicine, Dong-A University)
Han, Myoung Seok (Department of Obstetrics and Gynecology, College of Medicine, Dong-A University)
Rha, Seo Hee (Department of Pathology, College of Medicine, Dong-A University)
Kim, Seok Kwun (Department of Plastic Surgery, College of Medicine, Dong-A University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.32, no.4, 2005 , pp. 325-330 More about this Journal
Abstract
Objective: To investigate the histologic features of the uterus and adnexae extirpated from gender identity disorder (GID) patients that received depot androgen injection. Methods: We reviewed the histologic findings of the uterus and adnexae removed from sixteen GID patients, who had taken depot androgen injection for 5~168 months. Results: Fourteen patients (87.5%) showed the atrophied epithelium of exocervix and all of 16 patients (100%) showed the atrophy of endometrium. Seven patients (43.7%) showed multiple cystic follicles in the ovarian cortex and 6 patients (37.5%), 3 patients (18.7%) showed corpus albicans and corpus luteum, respectively. Conclusions: Exogenous androgen induced atrophy of cervix and endometrium. This effect was more prominent in the endometrium. In addition, PCO-like histologic features were observed in the ovary.
Keywords
Gender identity disorder (GID); Androgen therapy; Atrophy;
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  • Reference
1 Cameron DR, Braunstein GD. Androgen replacement therapy in women. Fertil Steril 2004; 82: 273-89   DOI   ScienceOn
2 Zuckerman S. Inhibition of menstruation and ovulation by means of testosterone propionate. Lancet 1937; 2: 676-80
3 Miller N, Bedard YC, Cooter NB, Shaul DL. Histological changes in the genital tract in transsexual women following androgen therapy. Histopathology 1986; 10: 661-9   DOI   PUBMED
4 Okon MA, Laird SM, Tuckerman EM, Li TC. Serum androgen levels in women who suffer recurrent miscarriage and their correlation with markers of endometrial function. Fertil Steril 1998; 69: 682-90   DOI   ScienceOn
5 Benjamin H. The transsexual phenomenon. New York: The Julian press Inc. Publishers; 1966
6 Papanicolaou GN, Ripley HS, Shorr E. Suppresive action of testosterone propionate on menstruation and its effect on vaginal smears. Proc Soc Exp Biol Med 1938; 24: 339-46
7 민성길. 성적 정체성 장애. In: 최신정신의학. 제 4판. 서울: 일조각; 2004, pp.453-60
8 Tulppala M, Stenman UH, Cacciatore B, Ylikorkala O. Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage: prospective study in 50 women. Br J Obstet Gynaecol 1993; 100: 348-52   DOI
9 Futterweit W, Deligdisch L. Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals. J Clin Endocrinol Metab 1986; 62: 16-21   DOI   PUBMED
10 Meyers JK, Reter DJ. Sex reassignment. Arch Gen Psychiatry 1979; 36: 1010-5   DOI   ScienceOn
11 The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81: 19-25
12 Greenblatt RB. Androgen therapy in women. Endocrinology 1942; 2: 665-6
13 Tuckerman EM, Okon MA, Li TC, Laird SM. Do androgens have a direct effect on endometrial function? An in vitro study. Fertil Steril 2004; 74: 771-9
14 Loeser AA. The action of testosterone propionate on the uterus and breast. Lancet 1938; 12: 373-4
15 Ihrke IA, D'Amour F. The influence of testis hormone upon the oestrous cycle in the rat. Am J Phys 1931; 96: 289-95