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Association Study of the Relationship between Endometriosis and Polymorphism of p53 Codon 72  

Hur, Sung-Eun (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University)
Shim, Soung-Shin (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University)
Lee, Kyung-Soon (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University)
Moon, Hye-Sung (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University)
Yu, Han-Ki (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University)
Chung, Hye-Won (Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.29, no.4, 2002 , pp. 311-315 More about this Journal
Abstract
Objective: The present study was performed to evaluate the association o f p53 codon 72 polymorphism and endometriosis. Materials and Methods: We investigate 74 women who were operated for endometriosis and 93 women who had no endometriotic lesion proved by operation. Polymerase chain reaction was used to detect p53 codon polymorphisms. Result: We have found no significant difference between endometriosis and control group in the p53 codon polymorphism. The respective proportion of arginine homozygotes, heterozygotes and proline homozygotes in endometriosis group were 18.9%, 62.2% and 18.9%, respectively, and were 12.9%, 75.2% and 11.9%, respective in the group without endometriosis. Conclusion: Endometriosis is not associated with p53 polymorphism in Korean endometriosis patients.
Keywords
Endometriosis; p53; Polymorphism; Arginine; Proline;
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