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Clinical Consideration of Obese Infertile Women  

Nam, Yoon-Sung (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University)
Jeong, Chang-Jin (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University)
Kim, Nam-Keun (Institute for Clinical Research, College of Medicine, Pocheon CHA University)
Yoon, Tae-Ki (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University)
Cha, Kwang-Yul (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.29, no.3, 2002 , pp. 209-214 More about this Journal
Abstract
Objective : To analyze the clinical characteristics of obese infertile women. Material and Method: Height, weight, body mass index, menstrual pattern, glucose, insulin, glucose/insulin ratio, dehydroepiandrosterone sulfate (DHEA-S), testosterone, free testosterone and plasminogen activator inhibitor (PAI-1) of 15 obese infertile women were tested. Results: Of 15 obese infertile women, the number of diabetes mellitus, hyperinsulinemia, and insulin resistance was 2 (13%), 2 (13%), 2 (13%), respectively. The incidence of increased DHEA-S, testosterone, and free testosterone was 7 (47%), 1 (7%), 6 (40%), respectively. Notably, all patients showed increased PAI-1. Conclusions: Obesity is associated with infertility as well as many kinds of health problems. Obesity is closely related to insulin resistance and it also causes hyperandrogenism. Increased PAI-1 is one of the important causes of thrombophilia. Consequently, in the workup of obese infertile patient, many aspects of health problems should be considered.
Keywords
Obesity; Infertility;
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