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http://dx.doi.org/10.6116/kjh.2022.37.4.17.

The comparative study on the anti-obesity effect of Arctium lappa L. roots with and without microwave processing  

Seo, Seong-Wook (Department of Rehabilitation Sciences, Graduate School, Daegu University)
Kim, Min Ju (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Kim, Kyoung (Department of Physical Therapy, College of Rehabilitation Sciences, Daegu University)
Chung, Dong-Min (ShinWoo co.)
Shin, Mi-Rae (Department of Herbology, College of Korean Medicine, Daegu Haany University)
Publication Information
The Korea Journal of Herbology / v.37, no.4, 2022 , pp. 17-29 More about this Journal
Abstract
Objective : The present study comparatively analyzed the anti-obesity effect of Arctium lappa L. roots with and without microwave processing. Methods : Four HFD groups except for the Normal group (n=8) were allocated: Control, microwave-processed dried Arctium lappa L. roots (MAL) extract 400 mg/kg/d (MAL400), MAL extract 800 mg/kg/d (MAL800), and the dried Arctium lappa L. roots (DAL) extract 800 mg/kg/d (DAL800). The efficacy of MAL and DAL was confirmed in terms of the serum biochemical index, protein expressions related to the synthesis of triglyceride (TG) and total cholesterol (TC) and 𝛽-oxidation, and histopathological staining. Results : Both MAL and DAL treatments significantly reduced final body weight and body weight gain. MAL800 treatment significantly reduced serum TG, TC, low-density lipoprotein cholesterol, and leptin levels, but the serum high-density lipoprotein cholesterol and adiponectin concentrations were dramatically increased. In particular, leptin in the MAL800 group was reduced by 14.1% compared with the DAL800 group. Moreover, the MAL800 treatment showed an effect superior to the DAL800 treatment in the reduction of serum TC, the sirtuin 1 (Sirt1) activation, and the inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGCR) gene expression. In particular, unlike the DAL800 treatment, MAL treatment significantly led to the activation of peroxisome proliferator-activated receptor alpha (PPAR𝛼). Subsequently, PPAR𝛼 meaningfully regulated downstream proteins associated with 𝛽-oxidation. Conclusion : These findings suggest that Arctium lappa L. roots with microwave processing effectively ameliorate obesity through the regulation of leptin and TC and the promotion of 𝛽-oxidation compared with Arctium lappa L. roots without microwave processing.
Keywords
Arctium lappa L. roots; microwave processing; high-fat diet; leptin; total cholesterol; anti-obesity;
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1 Cooper AJ, Gupta SR, Moustafa AF, Chao AM. Sex/Gender Differences in Obesity Prevalence, Comorbidities, and Treatment. Curr Obes Rep. 2021;10(4):458-66.   DOI
2 Lighter J, Phillips M, Hochman S, Sterling S, Johnson D, Francois F, Stachel A. Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission. Clin Infect Dis. 2020;71(15):96-7.
3 Soeroto AY, Soetedjo NN, Purwiga A, Santoso P, Kulsum ID, Suryadinata H, Ferdian F. Effect of increased BMI and obesity on the outcome of COVID-19 adult patients: A systematic review and meta-analysis. Diabetes Metab Syndr. 2020;14(6): 897-904.   DOI
4 Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6-10.   DOI
5 Sutaria S, Devakumar D, Yasuda SS, Das S, Saxena S. Is obesity associated with depression in children? Systematic review and meta-analysis. Arch Dis Child. 2019;104(1):64-74.   DOI
6 Tak YJ, Lee SY. Long-Term Efficacy and Safety of Anti-Obesity Treatment: Where Do We Stand? Curr Obes Rep. 2021;10(1):14-30.   DOI
7 Lee J, Ha SJ, Park J, Kim YH, Lee NH, Kim YE, Hong YS, Song KM. Arctium lappa root extract containing L-arginine prevents TNF-α-induced early atherosclerosis in vitro and in vivo. Nutr Res. 2020;77:85-96.   DOI
8 Lou C, Zhu Z, Zhao Y, Zhu R, Zhao H. Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/-9 and heparanase in MDA-MB-231 cells. Oncol Rep. 2017;37(1):179-84.   DOI
9 Ha MS, Yook JS, Lee M, Suwabe K, Jeong WM, Kwak JJ, Soya H. Exercise training and burdock root (Arctium lappa L.) extract independently improve abdominal obesity and sex hormones in elderly women with metabolic syndrome. Sci Rep. 2021;11(1):5175.   DOI
10 Chen M, Xu J, Wang Y, Wang Z, Guo L, Li X, Huang L. Arctium lappa L. polysaccharide can regulate lipid metabolism in type 2 diabetic rats through the SREBP-1/SCD-1 axis. Carbohydr Res. 2020;494:108055.   DOI
11 Gomez-Hernandez A, Beneit N, Diaz-Castroverde S, Escribano O. Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications. Int J Endocrinol. 2016;2016:1216783.   DOI
12 Klop B, Elte JW, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013;5(4): 1218-40.   DOI
13 Carr MC, Brunzell JD. Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrinol Metab. 2004;89(6):2601-7.   DOI
14 Lee SH, Park HJ, Shin MR, Roh SS. Anti-Obesity Effect of Schizandrae Fructus Water Extract through Regulation of AMPK/Sirt1/PGC-1α signaling pathway. Kor J Herbology 2022;37(2):1-11.
15 Foretz M, Even PC, Viollet B. AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo. Int J Mol Sci. 2018;19(9):2826.   DOI
16 Zhang Y, Geng C, Liu X, Li M, Gao M, Liu X, Fang F, Chang Y. Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1. Mol Metab. 2016;6(1):138-47.   DOI
17 Lee WH, Kim SG. AMPK-Dependent Metabolic Regulation by PPAR Agonists. PPAR Res. 2010; 2010:549101.
18 Kersten S, Stienstra R. The role and regulation of the peroxisome proliferator activated receptor alpha in human liver. Biochimie. 2017;136:75-84.   DOI
19 Gug Man, Kim Yeon Seob, Byeon Seong Hui, Seo Bu Il, Kim Sang Chan, Jo Eung Haeng. The Oriental Medicines Effects on Cure and Prevention of an Obesty(2). Kor J Herbology 2000;15(1):73-82.
20 Chen L, Ma MY, Sun M, Jiang LY, Zhao XT, Fang XX, Man Lam S, Shui GH, Luo J, Shi XJ, Song BL. Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing. J Lipid Res. 2019;60(10):1765-75.   DOI
21 Lee MS, Kim JS, Cho SM, Lee SO, Kim SH, Lee HJ. Fermented Rhus verniciflua Stokes Extract Exerts an Antihepatic Lipogenic Effect in OleicAcid-Induced HepG2 Cells via Upregulation of AMP-Activated Protein Kinase. J Agric Food Chem. 2015;63(32):7270-6.   DOI
22 Marzuki SU, Pranoto Y, Khumsap T, Nguyen LT. Effect of blanching pretreatment and microwave-vacuum drying on drying kinetics and physicochemical properties of purple-fleshed sweet potato. J Food Sci Technol. 2021;58(8):2884-95.   DOI
23 Shin JH, Park YJ, Kim W, Kim DO, Kim BY, Lee H, Baik MY. Change of Ginsenoside Profiles in Processed Ginseng by Drying, Steaming, and Puffing. J Microbiol Biotechnol. 2019;29(2):222-9.   DOI
24 Park CH, Shin MR, An BK, Joh HW, Lee JC, Roh SS, Yokozawa T. Heat-Processed Scutellariae Radix Protects Hepatic Inflammation through the Amelioration of Oxidative Stress in Lipopolysaccharide-Induced Mice. Am J Chin Med. 2017;45(6):1233-52.   DOI
25 Yoo HH, Park JH, Kwon SW. In vitro cytotoxic activity of some Korean medicinal plants on human cancer cell lines: enhancement in cytotoxicity by heat processing. Phytother Res. 2007;21(9):900-3.   DOI
26 Meda V, Gupta M, Opoku A. Drying kinetics and quality characteristics of microwave-vacuum dried Saskatoon berries. J Microw Power Electromagn Energy. 2008;42(4):4-12.   DOI
27 Figiel A, Michalska A. Overall Quality of Fruits and Vegetables Products Affected by the Drying Processes with the Assistance of Vacuum-Microwaves. Int J Mol Sci. 2016;18(1):71.   DOI
28 Shin MR, Kim MJ, Lee JA, Roh SS. Effect of Uncaria rhynchophylla against Thioacetamide-Induced Acute Liver Injury in Rat. Can J Gastroenterol Hepatol. 2021;2021:5581816.
29 Goluch Z, Barbara K, Haraf G, Woloszyn J, Okruszek A, Werenska M. Impact of various types of heat processing on the energy and nutritional values of goose breast meat. Poult Sci. 2021;100(11): 101473.   DOI
30 Bhat SP, Sharma A. Current Drug Targets in Obesity Pharmacotherapy -A Review. Curr Drug Targets. 2017;18(8):983-93.   DOI
31 Maghsoumi-Norouzabad L, Alipoor B, Abed R, Eftekhar Sadat B, Mesgari-Abbasi M, Asghari Jafarabadi M. Effects of Arctium lappa L. (Burdock) root tea on inflammatory status and oxidative stress in patients with knee osteoarthritis. Int J Rheum Dis. 2016;19(3):255-61.   DOI
32 Wang D, Badarau AS, Swamy MK, Shaw S, Maggi F, da Silva LE, Lopez V, Yeung AWK, Mocan A, Atanasov AG. Arctium Species Secondary Metabolites Chemodiversity and Bioactivities. Front Plant Sci. 2019;10:834.   DOI
33 de Leeuw AJM, Oude Luttikhuis MAM, Wellen AC, Muller C, Calkhoven CF. Obesity and its impact on COVID-19. J Mol Med (Berl). 2021;99(7):899-915.   DOI
34 Kim DD, Basu A. Estimating the Medical Care Costs of Obesity in the United States: Systematic Review, Meta-Analysis, and Empirical Analysis. Value Health. 2016;19(5):602-13.   DOI
35 Busutil R, Espallardo O, Torres A, Martinez-Galdeano L, Zozaya N, Hidalgo-Vega A. The impact of obesity on health-related quality of life in Spain. Health Qual Life Outcomes. 2017;15(1):197.   DOI
36 Yang Y, Gao H, Liu W, Liu X, Jiang X, Li X, Wu Q, Xu Z, Zhao Q. Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK/mTOR-mediated autophagy. Phytomedicine. 2021;85:153526.   DOI
37 Gao Y, Gu C, Wang K, Wang H, Ruan K, Xu Z, Feng Y. The effects of hypoglycemia and weight loss of total lignans from Fructus Arctii in KKAy mice and its mechanisms of the activity. Phytother Res. 2018;32(4):631-42.   DOI
38 Kim MJ, Lee JH, Choi JW, Park HJ, Shin MR, Roh SS. Coix lacryma-jobi var. mayuen Stapf Sprout Extract Ameliorates High-Fat Diet-Induced Obesity by Upregulating LKB1/AMPK Signaling. Kor J Herbology 2021;36(6):39-46..   DOI
39 Schmier JK, Jones ML, Halpern MT. Cost of obesity in the workplace. Scand J Work Environ Health. 2006;32(1):5-11.   DOI
40 Shin YO, Park CH, Lee GH, Yokozawa T, Roh SS, Rhee MH. Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced Acute Lung Injury in Mice via NF-κB Signaling. Evid Based Complement Alternat Med. 2015;2015:456846.
41 Yang Y, Smith DL Jr, Keating KD, Allison DB, Nagy TR. Variations in body weight, food intake and body composition after long-term high-fat diet feeding in C57BL/6J mice. Obesity (Silver Spring). 2014;22(10):2147-55.   DOI
42 Gartshore A, Kidd M, Joshi LT. Applications of Microwave Energy in Medicine. Biosensors (Basel). 2021;11(4):96.   DOI
43 Wang Z, Lam KL, Hu J, Ge S, Zhou A, Zheng B, Zeng S, Lin S. Chlorogenic acid alleviates obesity and modulates gut microbiota in high-fat-fed mice. Food Sci Nutr. 2019;7(2):579-88.   DOI
44 He X, Zheng S, Sheng Y, Miao T, Xu J, Xu W, Huang K, Zhao C. Chlorogenic acid ameliorates obesity by preventing energy balance shift in high-fat diet induced obese mice. J Sci Food Agric. 2021;101(2): 631-7.   DOI
45 Mopuri R, Ganjayi M, Banavathy KS, Parim BN, Meriga B. Evaluation of anti-obesity activities of ethanolic extract of Terminalia paniculata bark on high fat diet-induced obese rats. BMC Complement Altern Med. 2015;15:76.   DOI
46 Stern JH, Rutkowski JM, Scherer PE. Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk. Cell Metab. 2016;23(5):770-84.   DOI
47 Jimenez-Saiz R, Benede S, Molina E, Lopez-Exposito I. Effect of processing technologies on the allergenicity of food products. Crit Rev Food Sci Nutr. 2015;55(13):1902-17.   DOI